应用 | 建议稀释比 | 已发表文章 |
---|---|---|
免疫印迹 (WB) |
0.25-0.1 µg/mL | - |
免疫组化(石蜡) (IHC (P)) |
5 µg/mL | - |
产品规格 | |
---|---|
种属反应 |
Bovine, Dog, Chicken, Horse, Human, Mouse, Non-human primate, Rat, Xenopus, Zebrafish |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic peptide (LGKRDFVDHLDKVDPVDG (aa23-40)) of ARRB2 protein. |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.5 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS |
内含物 |
0.05% sodium azide |
保存条件 |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2540820 |
Beta-arrestin-2, or ARRB2, is an adaptor protein belonging to the arrestin family with an N- arrestin domain and a C- arrestin domain. ARRB2 is a regulatory protein involved in heterotrimeric G protein-coupled receptor desensitization and is known to regulate beta2-adrenergic receptor (beta2AR) function by enhancing beta2AR mediated nuclear translocation of ERK. ARRB2 binds to phosphorylated beta2ARs, thereby causing a significant impairment of their capacity to activate G(S) proteins. Along with AIP4, ARRB2 acts as an endosomal sorting molecule that mediates CXCR4 entry into a degradative pathway. It may also be involved in hormone-specific desensitization of TSH receptors. ARRB2 is a Ca2+ binding protein of the retinal outer segments and binds to P-rhodopsin and is also involved in synaptic transmission in photoreceptor cells. It is widely expressed in most of the tissues, especially neuronal tissues and spleen.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: arrestin; arrestin 3; Arrestin beta-2; arrestin, beta 2; arrestin-3; beta arr2; beta-arrestin 2; beta-arrestin 2 long isoform; beta-arrestin 2 short isoform; Beta-arrestin-2; beta-arrestin2; DKFZp686L0365; HGNC:712; Non-visual arrestin-3; S-Arrestin
基因别名: AI326910; ARB2; ARR2; ARRB2; AW122872; BARR2; BARRES
UniProt ID: (Human) P32121, (Mouse) Q91YI4, (Rat) P29067
Entrez Gene ID: (Bovine) 281638, (Human) 409, (Horse) 100072892, (Dog) 607262, (Mouse) 216869, (Rat) 25388
分子生物学功能:
scaffold/adaptor protein