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Proteintech
c-Cbl Monoclonal Antibody (2F6D1)
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产品信息
66576-1-IG
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
2F6D1
抗原
c-Cbl Fusion Protein Ag23033 (578-906 aa encoded by BC132733)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: LPPVPSSRL GDSWLPRPIP KVPVSAPSSS DPWTGRELTN RHSLPFSLPS QMEPRPDVPR LGSTFSLDTS MSMNSSPLVG PECDHPKIKP SSSANAIYSL AARPLPVPKL PPGEQCEGEE DTEYMTPSSR PLRPLDTSQS SRACDCDQQI DSCTYEAMYN IQSQAPSITE SSTFGEGNLA AAHANTGPEE SENEDDGYDV PKPPVPAVLA RRTLSDISNA SSSFGWLSLD GDPTTNVTEG SQVPERPPKP FPRRINSERK AGSCQQGSGP AASAATASPQ LSSEIENLMS QGYSYQDIQK ALVIAQNNIE MAKNILREFV SISSPAHVAT (578-906 aa encoded by BC132733)
靶标信息
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL-3; CBLC; E3 ubiquitin-protein ligase CBL; fragile site, folic acid type, rare, fra(11)(q23.3); oncogene CBL2; Proto-oncogene c-Cbl; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF57; Signal transduction protein CBL
基因别名: C-CBL; CBL; CBL2; FRA11B; NSLL; RNF55
UniProt ID: (Human) P22681
Entrez Gene ID: (Human) 867
phosphotyrosine binding
transcription factor activity, sequence-specific DNA binding
ubiquitin-protein transferase activity
signal transducer activity
calcium ion binding
protein binding
zinc ion binding
ligase activity
SH3 domain binding
protein kinase binding
ephrin receptor binding
ubiquitin protein ligase activity
cadherin binding involved in cell-cell adhesion
ligase
metabolite interconversion enzyme
regulation of transcription, DNA-templated
cell surface receptor signaling pathway
epidermal growth factor receptor signaling pathway
transforming growth factor beta receptor signaling pathway
fibroblast growth factor receptor signaling pathway
positive regulation of phosphatidylinositol 3-kinase signaling
protein ubiquitination
negative regulation of epidermal growth factor receptor signaling pathway
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of apoptotic process
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of receptor-mediated endocytosis
cell-cell adhesion
