Proteintech

cIAP1 Polyclonal Antibody

19 篇参考文献
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说明书
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问题与答案
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说明书
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说明书
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cIAP1 Polyclonal Antibody

产品信息

10022-1-AP

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
查看14篇已发表文章 14篇已发表文章

免疫组化 (IHC)

-
查看2篇已发表文章 2篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:500
-

免疫细胞化学 (ICC/IF)

1:10-1:100
查看2篇已发表文章 2篇已发表文章

不适用 (N/A)

-
查看1篇已发表文章 1篇已发表文章
产品规格

种属反应

Human, Mouse

已发表种属

Human, Mouse, Zebrafish

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

cIAP1 Fusion Protein Ag15203 (1-350 aa encoded by BC016174)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.22 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

This BIRC2 antibody (10022-1-AP) can bind both full length (70 kDa) and cleaved form (60 kDa) of the protein.

Immunogen sequence: MHKTASQRL FPGPSYQNIK SIMEDSTILS DWTNSNKQKM KYDFSCELYR MSTYSTFPAG VPVSERSLAR AGFYYTGVND KVKCFCCGLM LDNWKLGDSP IQKHKQLYPS CSFIQNLVSA SLGSTSKNTS PMRNSFAHSL SPTLEHSSLF SGSYSSLSPN PLNSRAVEDI SSSRTNPYSY AMSTEEARFL TYHMWPLTFL SPSELARAGF YYIGPGDRVA CFACGGKLSN WEPKDDAMSE HRRHFPNCPF LENSLETLRF SISNLSMQTH AARMRTFMYW PSSVPVQPEQ LASAGFYYVG RNDDVKCFCC DGGLRCWESG DDPWVEHAKW FPRCEFLIRM KGQEFVDEIQ G (1-350 aa encoded by BC016174)

靶标信息

The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: apoptosis inhibitor 1; apoptosis inhibitor 2; baculoviral IAP repeat-containing 2; baculoviral IAP repeat-containing 3; Baculoviral IAP repeat-containing protein 2; C-IAP1; Cellular inhibitor of apoptosis 1; hIAP-2; IAP homolog B; IAP-2; Inhibitor of apoptosis protein 2; mIAP-2; mIAP2; NFR2-TRAF signalling complex protein; RING finger protein 48; RING-type E3 ubiquitin transferase BIRC2; TNFR2-TRAF-signaling complex protein 2

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基因别名: API1; Api2; AW146227; BIRC2; Birc3; c-IAP1; cIAP1; cIAP2; Hiap-2; HIAP1; HIAP2; IAP1; IAP2; mcIAP1; MIAP1; MIAP2; MIHB; MIHC; RNF48

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UniProt ID: (Human) Q13490, (Mouse) Q62210

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Entrez Gene ID: (Human) 329, (Mouse) 11797

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功能
transcription coactivator activity ubiquitin-protein transferase activity protein binding zinc ion binding transferase activity ligase activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process protein N-terminus binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity protease inhibitor
参与通路
protein polyubiquitination response to hypoxia placenta development transcription, DNA-templated regulation of transcription, DNA-templated cellular component disassembly involved in execution phase of apoptosis cell surface receptor signaling pathway I-kappaB kinase/NF-kappaB signaling regulation of tumor necrosis factor-mediated signaling pathway regulation of necrotic cell death tumor necrosis factor-mediated signaling pathway regulation of toll-like receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway NIK/NF-kappaB signaling regulation of RIG-I signaling pathway regulation of cell proliferation regulation of apoptotic process negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process regulation of innate immune response response to ethanol regulation of cell differentiation regulation of inflammatory response protein heterooligomerization response to cAMP regulation of cell cycle regulation of necroptotic process necroptotic process regulation of nucleotide-binding oligomerization domain containing signaling pathway mitotic spindle assembly negative regulation of ripoptosome assembly involved in necroptotic process positive regulation of protein K63-linked ubiquitination positive regulation of protein K48-linked ubiquitination positive regulation of protein monoubiquitination inhibition of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity regulation of reactive oxygen species metabolic process apoptotic process protein ubiquitination negative regulation of necroptotic process regulation of nucleic acid-templated transcription
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