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Invitrogen
cIAP2 Recombinant Rabbit Monoclonal Antibody (PSH06-92)
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cIAP2 Antibody (MA562406) in ICC/IF
Immunofluorescence analysis of cIAP2 was performed using 70% confluent log phase HeLa and MCF7 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with cIAP2 Recombinant Rabbit Monoclonal Antibody (PSH06-92) (Product # MA562406) at 1:100 dilution in 0.1% BSA, incubated at 4 degree Celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32790), (1:2,000 dilutio... View More
产品信息
MA562406
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH06-92
抗原
Recombinant protein within human cIAP2 aa 205-604.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Positive Control: Raji cell lysate, Daudi cell lysate, Ramos cell lysate, NCI-H1299 cell lysate.
Tissue Specificity: Tissue enhanced (intestine, lymphoid tissue).
Subcellular Location: Cytoplasm, Nucleus.
Sequence Similarities: 75% Mouse/Rat.
Predicted band size: 68 kDa.
靶标信息
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. Transcript variants encoding the same isoform have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AIP 2; API2; Apoptosis inhibitor 2; baculoviral IAP repeat-containing 3; Baculoviral IAP repeat-containing protein 3; C-IAP2; Cellular inhibitor of apoptosis 2; H HIAP1; H MALT2; hIAP-1; IAP homolog; IAP homolog C; IAP-1; Inhibitor of apoptosis protein 1; mammalian IAP homolog C; RING finger protein 49; RING-type E3 ubiquitin transferase BIRC3; TNFR2-TRAF signaling complex protein; TNFR2-TRAF-signaling complex protein 1
基因别名: AIP1; API2; BIRC3; c-IAP2; CIAP2; HAIP1; HIAP1; MALT2; MIHC; RNF49
UniProt ID: (Human) Q13489
Entrez Gene ID: (Human) 330
apoptotic process
cell surface receptor signaling pathway
I-kappaB kinase/NF-kappaB signaling
spermatogenesis
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein ubiquitination
positive regulation of protein ubiquitination
tumor necrosis factor-mediated signaling pathway
regulation of toll-like receptor signaling pathway
TRIF-dependent toll-like receptor signaling pathway
NIK/NF-kappaB signaling
regulation of RIG-I signaling pathway
regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of innate immune response
regulation of inflammatory response
protein heterooligomerization
regulation of necroptotic process
negative regulation of necroptotic process
regulation of nucleotide-binding oligomerization domain containing signaling pathway
mitotic spindle assembly
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cysteine-type endopeptidase activity
