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Invitrogen
eIF3b Polyclonal Antibody
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
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eIF3b Antibody (PA5-41773) in WB
Western blot was performed using Anti-eIF3b Polyclonal Antibody (Product # PA5-41773) and 110 kDa band corresponding to eIF3b was observed across cell lines tested along with an uncharacterized band at 120 kDa. Whole cell extracts (30 µg lysate) of A-431 (Lane 1), Hep G2 (Lane 2), HEK-293 (Lane 3), NIH/3T3 (Lane 4), K-562 (Lane 5), Jurkat (Lane 6), DU 145 (Lane 7), PANC-1 (Lane 8) and SH-SY5Y (Lane 9) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocel... View More
产品信息
PA5-41773
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the C-terminal of human EIF3S9
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2608473
产品详细信息
Peptide sequence: YRKMAQELYM EQKNERLELR GGVDTDELDS NVDDWEEETI EFFVTEEIIP
Sequence homology: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
靶标信息
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:9388245, PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:9388245, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: eIF-3-eta; eIF3 p110; eIF3 p116; EIF3B; Eukaryotic translation initiation factor 3 subunit 9; Eukaryotic translation initiation factor 3 subunit B; eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD); eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa; eukaryotic translation initiation factor 3, subunit B; hPrt1; MGC104664; MGC131875; Prt1 homolog
基因别名: EIF3-ETA; EIF3-P110; EIF3-P116; EIF3B; EIF3S9; PRT1
UniProt ID: (Human) P55884
Entrez Gene ID: (Human) 8662
