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产品信息
PA5-96548
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 694-913 of human EIF3C (NP_0037431)
偶联物
形式
Liquid
浓度
2.23 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2808350
产品详细信息
Immunogen sequence: EIPYMAAHES DARRRMISKQ FHHQLRVGER QPLLGPPESM REHVVAASKA MKMGDWKTCH SFIINEKMNG KVWDLFPEAD KVRTMLVRKI QEESLRTYLF TYSSVYDSIS METLSDMFEL DLPTVHSIIS KMIINEELMA SLDQPTQTVV MHRTEPTAQQ NLALQLAEKL GSLVENNERV FDHKQGTYGG YFRDQKDGYR KNEGYMRRGG YRQQQSQTAY; Positive Samples: MCF7, HL-60, HepG2, SW620, THP-1, Mouse testis; Cellular Location: Cytoplasm
靶标信息
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cell migration-inducing protein 17; eIF3 p110; eIF3 p110 {ECO:0000255|HAMAP-Rule:MF_03002}; eIF3c; eIF3c {ECO:0000255|HAMAP-Rule:MF_03002}; Eukaryotic translation initiation factor 3 subunit 8; eukaryotic translation initiation factor 3 subunit 8 {ECO:0000255|HAMAP-Rule:MF_03002}; Eukaryotic translation initiation factor 3 subunit C; eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002}; eukaryotic translation initiation factor 3, subunit 8 (110 kDa); eukaryotic translation initiation factor 3, subunit 8 (110kD); eukaryotic translation initiation factor 3, subunit 8, 110kDa; eukaryotic translation initiation factor 3, subunit C; extra-toes spotting; NIPI-like protein
基因别名: 110kDa; 3230401O13Rik; eIF3-p110; EIF3C; EIF3CL; EIF3S8; NIPIL(A3); NipilA3; Xs; Xsl
UniProt ID: (Human) Q99613, (Mouse) Q8R1B4, (Rat) B5DFC8
Entrez Gene ID: (Human) 8663, (Mouse) 56347, (Rat) 293484
