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产品信息
PA5-63944
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human eIF5A
偶联物
Unconjugated
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2640978
产品详细信息
Immunogen sequence: MCGTGGTDSK TRRPPHRASF LKRLE
Highest antigen sequence identity to the following orthologs: Mouse - 40%, Rat - 40%.
靶标信息
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of TP53/p53 and TP53/p53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: eIF-4D; eIF-5A; eIF-5A-1; eIF-5A1; eukaryotic initiation factor 5A; Eukaryotic initiation factor 5A isoform 1; Eukaryotic translation initiation factor 5A-1; MGC104255; MGC99547; OTTHUMP00000128384; Rev-binding factor; uORF A
基因别名: EIF-5A; EIF5A; EIF5A1; eIF5AI
UniProt ID: (Human) P63241
Entrez Gene ID: (Human) 1984
mRNA export from nucleus
translational frameshifting
protein export from nucleus
nucleocytoplasmic transport
apoptotic process
positive regulation of cell proliferation
peptidyl-lysine modification to peptidyl-hypusine
positive regulation of translational elongation
positive regulation of translational termination
