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Invitrogen
mDIC Polyclonal Antibody
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mDIC Antibody (PA3-840) in ICC/IF
Immunofluorescent analysis of MDC1 (green) showing staining in the cytoplasm and nucleus of C2C12 cells (right) compared to a negative control without primary antibody (left). Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with a MDC1 polyclonal antibody (Product # PA3-840) in 3% BSA-PBS at a dilution of 1:100 and incubated overnight at 4°C in a humidified chamber. Cells were washed with PBST and incubated with a DyLigh... View More
产品信息
PA3-840
产品规格
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the C-terminal residues L(276) R K H F G I K V P T T(287) of mDIC.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA3-840 detects mitochondrial dicarboxylate carrier protein(mDIC) in human and mouse cells.
PA3-840 has been successfully used in Western blotting and ICC/IF procedures. By Western blot it detects a 28 kDa protein representing mDIC.
The PA3-840 immunogen is a synthetic peptide corresponding to the C-terminal residues L(276) R K H F G I K V P T T(287) of mDIC.
靶标信息
The mitochondrial dicarboxylate carrier protein (mDIC) belongs to superfamily of mitochondrial transporters. It has been demonstrated that the expression of mDIC leads to hyperpolarization of the mitochondria, as well as succinate uptake by the mitochondria. It is highly expressed in adipose tissue, where its expression is downregulated by insulin and upregulated by free fatty acids. mDIC is also thought to play a role in glyceroneogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
