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产品信息
PA5-33829
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 19 amino acid peptide from N-terminal extracellular domain of human GRM7 / MGLUR7.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2551199
产品详细信息
Percent identity with other species by BLAST analysis: Human, Elephant, Bovine (100%).
靶标信息
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ40498; glutamate receptor; glutamate receptor, metabotropic 7; Metabotropic glutamate receptor 7; mGluR7; protein phosphatase 1, regulatory subunit 87
基因别名: GLUR7; GPRC1G; GRM7; MGLU7; MGLUR7; PPP1R87
UniProt ID: (Human) Q14831
Entrez Gene ID: (Human) 2917, (Bovine) 535362
conditioned taste aversion
behavioral fear response
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
chemical synaptic transmission
sensory perception of sound
sensory perception of smell
short-term memory
negative regulation of glutamate secretion
transmission of nerve impulse
adult behavior
negative regulation of cAMP biosynthetic process
regulation of cyclase activity
regulation of synaptic transmission, glutamatergic
calcium ion transmembrane transport
