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Invitrogen
p19 INK4d Recombinant Superclonal Antibody (14HCLC)
高级验证
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
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p19 INK4d Antibody (710851) in WB
Western blot analysis was performed on whole cell extracts (30 µg lysate) of HEK- 293 (Lane1), HEK- 293 treated with Trichostatin A, (Lane 2), HeLa (Lane 3), HeLa treated with Trichostatin A (Lane 4), HCT 116 (Lane 5), HCT 116 treated with Trichostatin A (Lane 6) (2uM/24hrs). The blots were probed with Anti-P19INK4D Recombinant Rabbit Polyclonal Antibody (Product # 710851, 0.5-1 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.4 µg/mL, 1:25... View More
产品信息
710851
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
14HCLC
抗原
Peptide corresponding to Human P19INk4d (aa 1-166)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2532773
产品详细信息
This antibody is predicted to react with Monkey, Pig, Rat and Mouse.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
靶标信息
p19 is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CDK inhibitor p19INK4d; cell cycle inhibitor, Nur77 associating protein; Cyclin-dependent kinase 4 inhibitor D; cyclin-dependent kinase 4 inhibitor D p19; cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4); inhibitor of cyclin-dependent kinase 4d; MTS1; p19-INK4d
基因别名: CDKN2D; INK4D; p19; p19-INK4D
UniProt ID: (Human) P55273
Entrez Gene ID: (Human) 1032
regulation of cyclin-dependent protein serine/threonine kinase activity
G1/S transition of mitotic cell cycle
DNA synthesis involved in DNA repair
cell cycle arrest
sensory perception of sound
negative regulation of cell proliferation
response to UV
negative regulation of cell growth
response to retinoic acid
response to vitamin D
negative regulation of phosphorylation
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
autophagic cell death
negative regulation of protein serine/threonine kinase activity
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
