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Product Details
37-8700
Applications
Tested Dilution
Publications
产品规格
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
2D2G4
Immunogen
A recombinant full length human p19 protein.
Conjugate
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.1% sodium azide
保存条件
-20°C
RRID
AB_2533344
Target Information
p19 is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
Bioinformatics
Protein Aliases: CDK inhibitor p19INK4d; cell cycle inhibitor, Nur77 associating protein; Cyclin-dependent kinase 4 inhibitor D; cyclin-dependent kinase 4 inhibitor D p19; cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4); inhibitor of cyclin-dependent kinase 4d; MTS1; p19-INK4d
Gene Aliases: CDKN2D; INK4D; p19; p19-INK4D
UniProt ID: (Human) P55273
Entrez Gene ID: (Human) 1032
regulation of cyclin-dependent protein serine/threonine kinase activity
G1/S transition of mitotic cell cycle
DNA synthesis involved in DNA repair
cell cycle arrest
sensory perception of sound
negative regulation of cell proliferation
response to UV
negative regulation of cell growth
response to retinoic acid
response to vitamin D
negative regulation of phosphorylation
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
autophagic cell death
negative regulation of protein serine/threonine kinase activity
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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