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Store as concentrated solution.
Centrifuge briefly prior to opening vial.
Positive control: A431 nuclear extract.
EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. p300 is related by sequence to CPB (CREB-binding protein [CREB: cyclic-AMP responsive element binding protein]), and like CPB can stimulate transcription through activation of CREB. This EP300 activity is specifically inhibited by the adenovirus oncoprotein E1A. EP300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: E1A-associated protein p300; E1A-binding protein, 300kD; Histone acetyltransferase p300; Histone butyryltransferase p300; Histone crotonyltransferase p300; p300 HAT; Protein 2-hydroxyisobutyryltransferase p300; Protein lactyltransferas p300; Protein propionyltransferase p300
基因别名: A430090G16; A730011L11; EP300; KAT3B; P300; p300 HAT; RSTS2
UniProt ID: (Human) Q09472, (Mouse) B2RWS6
Entrez Gene ID: (Human) 2033, (Mouse) 328572