Invitrogen

p40 (DeltaNp63) Recombinant Rabbit Monoclonal Antibody (RM392)

问题与答案

问题与答案

抗体检测数据 (2)

p40 (DeltaNp63) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

p40 (DeltaNp63) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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p40 (DeltaNp63) Antibody (MA562093) in IHC (P)

Immunohistochemistry (Paraffin) analysis of human lung squamous carcinoma tissue section using p40 (DeltaNp63) recombinant monoclonal antibody (Product # MA562093) at 1:50 dilution.

p40 (DeltaNp63) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

p40 (DeltaNp63) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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p40 (DeltaNp63) Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry (Paraffin) analysis of human lung squamous carcinoma tissue section using p40 (DeltaNp63) recombinant monoclonal antibody (Product # MA562093) at 1:50 dilution.

p40 (DeltaNp63) Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry (Paraffin) analysis of human prostate tissue section using p40 (DeltaNp63) recombinant monoclonal antibody (Product # MA562093) at 1:200 dilution.

产品信息

MA562093

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:200

-

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

RM392

抗原

A peptide corresponding to Human p40 (DeltaNp63).

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

Conc. Not Determined

纯化类型

Protein A

保存液

PBS with 1% BSA, 50% glycerol

内含物

0.09% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

This antibody reacts to human p40 (deltaNp63).

靶标信息

p40, also known as DeltaNp63, is an isoform of the p63 gene, which is a member of the p53 family of transcription factors. p63 plays a crucial role in the development and maintenance of epithelial tissues, and DeltaNp63 specifically acts as a dominant-negative inhibitor of p53 and other p63 isoforms. This inhibition is vital for the regulation of cell proliferation, differentiation, and apoptosis in epithelial cells. DeltaNp63 is highly expressed in the basal layers of epithelial tissues, including the skin, where it contributes to the regenerative capacity of these tissues. Abnormal expression of DeltaNp63 has been implicated in various cancers, particularly those originating from epithelial cells, such as squamous cell carcinoma. Understanding the function and regulation of p40/DeltaNp63 is essential for developing targeted therapies for these malignancies.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: amplified in squamous cell carcinoma; Chronic ulcerative stomatitis protein; CUSP; Keratinocyte transcription factor KET; p40; p51; p63; p73L; TP63; Transformation-related protein 63; Tumor protein 63; tumor protein p53-competing protein; Tumor protein p73-like

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基因别名: AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; p40; p51; p53CP; P63; P73H; P73L; RHS; SHFM4; TP53CP; TP53L; TP63; TP73L

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UniProt ID: (Human) Q9H3D4

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Entrez Gene ID: (Human) 8626

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transcription factor activity, transcription factor binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding p53 binding DNA binding chromatin binding damaged DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding identical protein binding sequence-specific DNA binding transcription regulatory region DNA binding metal ion binding WW domain binding P53-like transcription factor

negative regulation of transcription from RNA polymerase II promoter replicative cell aging skeletal system development establishment of planar polarity positive regulation of mesenchymal cell proliferation epithelial cell development chromatin remodeling transcription from RNA polymerase II promoter apoptotic process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Notch signaling pathway spermatogenesis ectoderm and mesoderm interaction proximal/distal pattern formation response to X-ray multicellular organism aging response to gamma radiation epidermal cell division regulation of epidermal cell division positive regulation of keratinocyte proliferation keratinocyte differentiation embryonic limb morphogenesis polarized epithelial cell differentiation hair follicle morphogenesis mitotic G1 DNA damage checkpoint cellular response to UV post-anal tail morphogenesis odontogenesis of dentin-containing tooth intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of apoptotic process negative regulation of apoptotic process regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of neuron apoptotic process skin morphogenesis keratinocyte proliferation negative regulation of keratinocyte differentiation positive regulation of osteoblast differentiation positive regulation of Notch signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter sympathetic nervous system development smooth muscle tissue development female genitalia morphogenesis protein homotetramerization neuron apoptotic process urinary bladder development cloacal septation prostatic bud formation squamous basal epithelial stem cell differentiation involved in prostate gland acinus development establishment of skin barrier positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway regulation of signal transduction by p53 class mediator positive regulation of fibroblast apoptotic process negative regulation of mesoderm development