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p70 S6 Kinase Polyclonal Antibody

查看其他57个p70 S6 Kinase抗体

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说明书
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问题与答案
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说明书
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p70 S6 Kinase Polyclonal Antibody

产品信息

600-401-942

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

酶联免疫吸附实验 (ELISA)

1:5,000
-

免疫沉淀 (IP)

5 µg/mg
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the carboxy terminal end of human p70S6K protein.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

0.1M tris HCl/TBS, pH 8

内含物

0.01% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Store at -20°C prior to opening.

Aliquot contents and freeze at -20°C or below for extended storage.

Centrifuge product if not completely clear after standing at room temperature.

This product is stable for several weeks at 4°C as an undiluted liquid (dilute only prior to immediate use).

靶标信息

RPS6KB1 (p70S6K) is a serine/threonine kinase with 2 non-identical kinase catalytic domains which phosphorylates several residues of the S6 ribosomal protein. p70 S6 kinase is predominantly localized in the cytoplasm, and is essential in growth factors regulated cell proliferation, pathways involving cell motility, such as metastases, the immune response, and tissue repair. p70 S6 kinase acts downstream of phosphoinositide (PI) 3-kinase, and its main physiological target is the S6 ribosomal protein, which is involved in upregulation of protein synthesis. The kinase activity of p70 S6 kinase leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding p70 S6 kinase and overexpression are seen in some breast cancer cell lines.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: 70 kDa ribosomal protein S6 kinase 1; EC 2.7.11.1; kinase p70S6K; KS6B1; p70 p70-S6K; p70 ribosomal S6 kinase alpha; p70 S6 kinase alpha; p70 S6 kinase, alpha; p70 S6K-alpha; p70 S6KA; p70-S6K 1; p70S6K-alpha; P70S6K1; p80-S6K 1; p85 p85S6K; Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase I; ribosomal protein S6 kinase, 70kD, polypeptide 1; ribosomal protein S6 kinase, 70kDa, polypeptide 1; S6K; S6K-beta-1; serine/threonine kinase 14 alpha; Serine/threonine-protein kinase 14A

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基因别名: 2610318I15Rik; 4732464A07Rik; 70kDa; AA959758; AI256796; AI314060; p70 S6KA; p70(S6K)-alpha; p70-alpha; p70-S6K; p70/85s6k; p70s6k; PS6K; RPS6KB1; S6K; S6K-beta-1; S6K1; STK14A

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UniProt ID: (Human) P23443, (Mouse) Q8BSK8

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Entrez Gene ID: (Human) 6198, (Mouse) 72508

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功能
protein kinase activity ribosomal protein S6 kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding kinase activity PDZ domain binding peptide binding identical protein binding protein phosphatase 2A binding nucleotide binding protein serine/threonine kinase activity transferase activity transferase activity, transferring phosphorus-containing groups protein modifying enzyme
参与通路
G1/S transition of mitotic cell cycle behavioral fear response skeletal muscle contraction protein phosphorylation apoptotic process signal transduction germ cell development aging response to nutrient long-term memory response to heat response to wounding response to mechanical stimulus response to toxic substance response to glucose skeletal muscle atrophy response to electrical stimulus involved in regulation of muscle adaptation positive regulation of smooth muscle cell migration cell migration TOR signaling response to lipopolysaccharide response to insulin cellular response to hormone stimulus response to testosterone response to glucagon response to tumor necrosis factor response to drug negative regulation of apoptotic process response to leucine protein kinase B signaling response to ethanol positive regulation of translation positive regulation of mitotic cell cycle positive regulation of translational initiation regulation of glucose import negative regulation of insulin receptor signaling pathway phosphatidylinositol-mediated signaling positive regulation of skeletal muscle tissue growth positive regulation of smooth muscle cell proliferation response to glucocorticoid cellular response to growth factor stimulus cellular response to organic cyclic compound negative regulation of extrinsic apoptotic signaling pathway regulation of translation cell cycle phosphorylation cellular response to insulin stimulus
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