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Invitrogen
pan Cytokeratin Monoclonal Antibody (PCK-26)
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产品信息
MA1-22153
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
PCK-26
抗原
Purified, full length, native, human pan cytokeratin protein from human epidermis.
偶联物
形式
Liquid
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
MA1-22153 detects pan cytokeratin in human, bovine, mouse, rabbit, sheep, goat and rat samples. The antibody reacts with simple, cornifying, and non-cornifying squamous epithelia and pseudostratified epithelia. It does not react with non-epithelial normal human tissues.
MA1-22153 has been successfully used in immunofluorescence, immunohistochemistry, immunohistochemistry (frozen and paraffin), dot blot and Western blot procedures, where bands of 58 kDa (Cytokeratin 5), 56 kDa (Cytokeratin 6), and 52 kDa (Cytokeratin 8) are detected.
The MA1-22153 immunogen is purified, full length, native, human pan cytokeratin protein from human epidermis.
Store at 4°C short term. For long term storage, aliquot and store at -20°C, avoiding freeze/thaw cycles.
靶标信息
Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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