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Invitrogen
pro-GDF3 Monoclonal Antibody (356613)
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产品信息
MA5-61341
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
356613
抗原
Mouse myeloma cell line NS0-derived recombinant mouse GDF-3 Propeptide, Ser23-Lys250
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
Pro-GDF3, or pro-growth differentiation factor 3, is the precursor form of GDF3, a member of the transforming growth factor-beta (TGF-beta) superfamily. GDF3 is involved in various biological processes including embryonic development, cell differentiation, and regulation of adipose tissue homeostasis. Pro-GDF3 undergoes proteolytic processing to become the mature, active form that can then bind to its receptors and initiate signaling pathways. GDF3 plays a critical role in early embryogenesis, particularly in the formation of the mesoderm and endoderm, and in maintaining the pluripotency of embryonic stem cells. Additionally, GDF3 has been implicated in metabolic regulation and in the pathogenesis of obesity and type 2 diabetes. Abnormal expression or mutations in the GDF3 gene can lead to developmental disorders and contribute to disease states. As a result, pro-GDF3 and its mature form are of significant interest in developmental biology, regenerative medicine, and metabolic disease research, offering potential targets for therapeutic intervention.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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