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Invitrogen
pro-Kallikrein 5 Monoclonal Antibody (325302)
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产品信息
MA5-60921
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
325302
抗原
Mouse myeloma cell line NS0-derived recombinant human Kallikrein 5, Val23-Arg66
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
Pro-Kallikrein 5 (KLK5) is a member of the kallikrein-related peptidase family, which comprises serine proteases involved in various physiological processes. KLK5 is encoded by the KLK5 gene located on chromosome 19 in humans. This enzyme is initially synthesized as an inactive zymogen, pro-Kallikrein 5, and is activated through proteolytic cleavage. KLK5 plays a critical role in skin desquamation, the process of shedding dead skin cells, by degrading intercellular adhesive proteins in the epidermis. It is also implicated in the regulation of inflammation and immune responses. Abnormal expression or activity of KLK5 has been linked to skin disorders such as Netherton syndrome and atopic dermatitis, as well as certain cancers. Due to its involvement in these conditions, KLK5 is being studied as a potential biomarker and therapeutic target for disease diagnosis and treatment. Understanding the regulation and function of KLK5 can provide insights into skin homeostasis and the pathogenesis of related diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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