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Invitrogen
pyrrolizidinealkaloids Recombinant Mouse Monoclonal Antibody (1B6)
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pyrrolizidinealkaloids Antibody (MA566341) in SDS-PAGE
SDS-PAGE characterization of pyrrolizidinealkaloids under reducing conditions. Lane M: Protein marker (kDa); Lane PAs: Purified pyrrolizidinealkaloids Recombinant Monoclonal (Product # MA566341). pyrrolizidinealkaloids showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-297.
产品信息
MA566341
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1B6
抗原
Conjugate of PAs hapten and KLH.
偶联物
形式
Liquid
浓度
4.7 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Pyrrolizidine alkaloids (PAs) are naturally occurring compounds found in various plant genera such as Senecio, Crotalaria, Heliotropium, Echium, Tirchodesma, and Amsinckia. These alkaloids are characterized by their pyrrolizidine scaffold, which is synthesized in plants and can be activated in the liver by mixed function oxidases to form toxic pyrrole derivatives. PAs are known for their pronounced toxicity, particularly hepatotoxicity, and have been identified as potent hepatocarcinogens in laboratory rodents. Despite their toxicity, PAs exhibit a wide range of biological activities, including potential pharmacological properties as glycosidase inhibitors, making them candidates for drug development in treating diseases such as cancer, diabetes, and viral infections. The interest in PAs stems from their complex structure and the challenge of synthesizing them, as well as their significant impact on human health due to their presence in food and phytomedicine.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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