Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
MUbio
vitronectin receptor CD51 Monoclonal Antibody (NKI-M7 (former AMF7))
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
MUB2011P
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
NKI-M7 (former AMF7)
抗原
Human vitronectin receptor CD51
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
T-lymphocyte clones NKI-M7 detect a melanoma-associated proteoglycan (MW greater than 450-250 kDa) and a molecular complex, which under reducing conditions consists of 4 compounds of 120, 95, 29 and 25 kDa respectively. NKI-M7 reacts with cultured melanomas melanomas in frozen sections. The antigen detected by NKI-M7 is strongly associated with the adhesion and cytoplasmic spreading of melanoma cells to plastic surfaces and monolayers of vascular endothelial cells. NKI-M7 blocks fibronectin-induced chemotaxic motility and chemokinesis of melanoma cells. In addition to their membrane localization, the antigens detected by NKI-M7are abundant in extracellular adhesion plaques deposited by cultured melanoma cells. NKI-M7 stains primary tumors heterogeneously, whereas metastases are homogeneously stained.
靶标信息
ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8, 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands, the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: antigen identified by monoclonal antibody L230; CD51; CD61; GP3A; GPIIIa; integrin alpha V; Integrin alpha-V; integrin alphaVbeta3; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); ITGB3; Vitronectin receptor; Vitronectin receptor subunit alpha; VNR
基因别名: CD51; ITGAV; MSK8; VNRA; VTNR
UniProt ID: (Human) P06756
Entrez Gene ID: (Human) 3685
virus receptor activity
opsonin binding
fibronectin binding
protease binding
protein kinase C binding
voltage-gated calcium channel activity
protein binding
coreceptor activity
fibroblast growth factor binding
C-X3-C chemokine binding
insulin-like growth factor I binding
neuregulin binding
metal ion binding
transforming growth factor beta binding
extracellular matrix binding
extracellular matrix protein binding
integrin
angiogenesis
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
positive regulation of cell proliferation
negative regulation of macrophage derived foam cell differentiation
negative regulation of lipid storage
cell growth
cell migration
extracellular matrix organization
positive regulation of cell migration
cell-substrate adhesion
negative regulation of lipid transport
positive regulation of osteoblast proliferation
heterotypic cell-cell adhesion
substrate adhesion-dependent cell spreading
endodermal cell differentiation
apolipoprotein A-I-mediated signaling pathway
apoptotic cell clearance
negative regulation of low-density lipoprotein particle receptor biosynthetic process
positive regulation of cell adhesion
viral entry into host cell
vascular endothelial growth factor receptor signaling pathway
negative regulation of lipoprotein metabolic process
regulation of phagocytosis
leukocyte migration
negative chemotaxis
entry of symbiont into host cell by promotion of host phagocytosis
ERK1 and ERK2 cascade
calcium ion transmembrane transport
extrinsic apoptotic signaling pathway in absence of ligand
regulation of apoptotic cell clearance
negative regulation of entry of bacterium into host cell
negative regulation of extrinsic apoptotic signaling pathway
