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Human Angiotensinogen quantitates human Angiotensinogen in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Angiotensinogen.
The protein encoded by AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : AGT, ANHU, SERPINA8
基因ID : (Human) 183
基因符号 : AGT
蛋白别名 : alpha-1 antiproteinase, antitrypsin, angiotensin I, angiotensin II, Angiotensinogen, angiotensinogen (serpin peptidase inhibitor, clade A, member 8), pre-angiotensinogen, serine (or cysteine) proteinase inhibitor, Serpin A8, serpin peptidase inhibitor, member 8
UniProt ID (Human) P01019