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Human IL-17 RB quantitates human IL-17 RB in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human IL-17 RB.
Recently, a number of cytokines belonging to the interleukin (IL)-17 family have been identified. These are termed as IL-17B, IL-17C (1) and IL-17E. IL-17 is a potent proinflammatory cytokine that plays roles in a number of diseases including rheumatoid arthritis, multiple sclerosis, and promotion of tumor growth. IL-17B, C, and E like IL-17 are able to induce proinflammatory responses. However, they do not bind to the IL-17 receptor suggesting that additional IL-17R related receptor might exist. Receptor for IL-17B and IL-17E has been independently isolated and has been designated as EV127 (in mouse) and IL-17Rh1 (in human), respectively. IL-17E induces activation of NF-kB pathway and like IL-17 also induces production of IL-8. IL-17Rh1 mRNA is highly expressed in Kidney and liver and at moderate level in small intestine, colon, and brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
基因别名 : CRL4, EVI27, IL17BR, IL17RH1
基因ID : (Human) 55540
基因符号 : IL17RB
蛋白别名 : cytokine receptor CRL4, cytokine receptor-like 4, EVI27A, IL-17 receptor B, IL-17 receptor homolog 1, IL-17B receptor, IL-17B, IL-20, MGC138900, MGC138901, MGC5245, ZCYTO7, IL-17RB, IL-17Rh1, interleukin 17 receptor homolog 1, interleukin-17B receptor
UniProt ID (Human) Q9NRM6