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Human IRAK4 ELISA Kit is an enzyme-linked immunosorbent assay for quantitative detection of human IRAK4 in cell culture supernatants, plasma, and serum samples.
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. Overexpression of IRAK-4 activates NF-kappa-B and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : IPD1, IRAK-4, IRAK4, NY-REN-64, REN64
基因ID : (Human) 51135
基因符号 : IRAK4
蛋白别名 : interleukin-1, Interleukin-1 receptor-associated kinase 4, IRAK-4, Renal carcinoma antigen NY-REN-64
UniProt ID (Human) Q9NWZ3