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Human ITGA2 quantitates human ITGA2 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human ITGA2.
CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex. VLA-2 is an extracellular receptor for laminin, collagen, and fibronectin, and interaction with its ligands results in the activation of intracellular signaling pathways. It has reported roles in VEGF-induced angiogenesis in vivo, as well as adhesion and lymphocyte activation. CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, and epithelial cells. It is also expressed on adaptive immune cells such as T and B cells, specifically on a subset of CD4+ T cells in the spleen, on intraepithelial and lamina propria lymphocytes in the intestine, as well as on a population of peripheral CD4+ type 1 T regulatory (Tr1) cells that co-express LAG-3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : BR, CD49B, GPIa, HPA-5, ITGA2, VLA-2, VLAA2
基因ID : (Human) 3673
基因符号 : ITGA2
蛋白别名 : alpha 2 subunit of VLA-2 receptor, BDPLT9, VLA2 receptor, CD49 antigen-like family member B, CD49b, Collagen receptor, GPIa, human platelet alloantigen system 5, Integrin alpha-2, integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), platelet antigen Br, platelet glycoprotein GPIa, Platelet membrane glycoprotein Ia, very late activation protein 2 receptor, alpha-2 subunit, VLA-2 subunit alpha
UniProt ID (Human) P17301