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Human LTF/Lactoferrin quantitates human LTF/Lactoferrin in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human LTF/Lactoferrin.
Lactoferrin (LF) is an iron binding glycoprotein. LF consists of a single polypeptide chain (approximately 80 kDa) folded into two structurally homologous lobes, each of which can reversibly bind one ferric ion (Fe3+). LF is found in external fluids, including milk and mucosal secretions, and is a prominent component of secondary granuals of neutrophils. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. LTF acts as a major first line defense against microbial infections, partly due to its ability to efficiently bind to and hence remove Fe3+ from the environment, but studies have also shown that LTF possesses bactericidal properties and proteolytic activity, capable of cleaving arginine-rich sequences within microbial proteins. Three isoforms of LTF have been identified: LTF-alpha, LTF-beta and LTF-gamma and receptors for LTF are expressed in the gastrointestinal tract, by macrophages, lymphocytes, neutrophils and platelets and also by some bacteria.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : GIG12, HEL110, HLF2, LF, LTF
基因ID : (Human) 4057
基因符号 : LTF
蛋白别名 : CKRX, Kaliocin 1, Kaliocin1, Lactoferricin H, LactoferroxinA, LactoferroxinB, LactoferroxinC, Lfcin H, LfcinH, epididymis luminal protein 110, Growth-inhibiting protein 12, kaliocin-1, lactoferricin, Lactoferrin, lactoferroxin, Lactotransferrin, neutrophil lactoferrin, Talalactoferrin
UniProt ID (Human) P02788