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Invitrogen
Human MST1 (STK4) ELISA Kit
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产品规格
检测灵敏度
9.6 pg/mL
测定范围
9.6-3,000 pg/mL
检测样本类型/体积
{Supernatant=100 µL, Plasma=100 µL, Serum=100 µL}
手工操作时间
1 hr 20 min
总时间
4 hr 45 min
均相（无需洗涤）
No
批间差异
12%
批内差异
10%
检测仪器
Absorbance Microplate Reader
产品规格
96 Tests
产品成分
Pre-coated microwell plate
Standard
Biotinylated Detection Antibody
Streptavidin-HRP
Sample Diluent
Wash Buffer Concentrate
Assay Buffer concentrate
Stop Solution
Substrate Solution
Adhesive Plate Covers
Standard
Biotinylated Detection Antibody
Streptavidin-HRP
Sample Diluent
Wash Buffer Concentrate
Assay Buffer concentrate
Stop Solution
Substrate Solution
Adhesive Plate Covers
运输条件
Wet ice
储存
-20°C
蛋白名称
MST1 (STK4)
均相（无需洗涤）
Human
检测试剂盒格式
Sandwich ELISA Kit
检测抗体结合物
Biotin
标签或染料
HRP
关于本试剂盒
Human MST1 (STK4) ELISA Kit is an enzyme-linked immunosorbent assay for quantitative detection of human STK4.
靶标信息
STK4 (MST1) is a serine/threonine kinase which may be involved in apoptosis. It is possible that this protein induces the chromatin condensation observed in this process. STK4 is a stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. It is a key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
基因别名 : KRS2, MST1, STK4, YSK3
基因ID : (Human) 6789
基因符号 : STK4
蛋白别名 : EC 2.7.11.1, kinase MST1, TIIAC, kinase responsive to stress 2, Mammalian STE20-like protein kinase 1, mammalian sterile 20-like 1, MST-1, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase Krs-2, STE20-like kinase MST1
UniProt ID (Human) Q13043
