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产品规格
检测灵敏度
61 pg/mL
测定范围
61-15 ng/mL
检测样本类型/体积
{Supernatant=50 µL, Serum=50 µL, Plasma=50 µL}
手工操作时间
1 hr 20 min
总时间
4 hr 45 min
均相（无需洗涤）
No
批间差异
<12%
批内差异
<10%
检测仪器
Absorbance Microplate Reader
产品规格
96 Tests
产品成分
Pre-coated 96 well plate
Standard
Assay Diluent concentrate
Biotinylated Detection Antibody
SAV-HRP
Wash Buffer
Chromogen
Stop Solution
Adhesive Plate Covers
Standard
Assay Diluent concentrate
Biotinylated Detection Antibody
SAV-HRP
Wash Buffer
Chromogen
Stop Solution
Adhesive Plate Covers
运输条件
Wet ice
储存
2-8°C
蛋白名称
Pro-Cathepsin B
均相（无需洗涤）
Human
检测试剂盒格式
Sandwich ELISA Kit
检测抗体结合物
Biotin
标签或染料
HRP
关于本试剂盒
Human Pro-Cathepsin B quantitates human Pro-Cathepsin B in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Pro-Cathepsin B.
靶标信息
Pro-Cathepsin B is the inactive precursor of Cathepsin B, a lysosomal cysteine protease that plays a significant role in both physiological and pathological processes. Synthesized in the endoplasmic reticulum, pro-Cathepsin B undergoes maturation in the acidic environment of the lysosome, where it is activated. Structurally, Cathepsin B consists of a heavy chain and a light chain forming a bi-lobal enzyme with a critical region known as the "occluding loop," which dictates its substrate specificity and activity. Functionally, Cathepsin B is involved in intracellular protein turnover, aiding in the degradation of proteins within endosomes and lysosomes. It also has crucial roles in extracellular matrix remodeling, facilitating processes such as cell migration, invasion, and angiogenesis, particularly in the context of cancer. Dysregulation of Cathepsin B activity is linked to various diseases, including tumor metastasis, neurodegenerative disorders, and inflammatory conditions, making it an important target for therapeutic intervention.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
基因别名 : APPS, CPSB, CTSB
基因ID : (Human) 1508
基因符号 : CTSB
蛋白别名 : amyloid precursor protein secretase, APP secretase, APPS, Cathepsin B, Cathepsin B1, cysteine protease, ProCTSB
UniProt ID (Human) Q96D87
