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Human TAFA5/FAM19A5 quantitates human TAFA5/FAM19A5 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human TAFA5/FAM19A5.
Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2. Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway. Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes. Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2. Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling . Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : FAM19A5, QLLK5208, TAFA-5, TAFA5, UNQ5208, UNQ5208/PRO34524
基因ID : (Human) 25817
基因符号 : FAM19A5
蛋白别名 : Chemokine-like protein TAFA-5, family with sequence similarity 19 (chemokine (C-C motif)-like), member A5, TAFA protein 5
UniProt ID (Human) Q7Z5A7