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Invitrogen
Mouse FAS/TNFRSF6/Apo-1 ELISA Kit
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产品规格
检测灵敏度
8.2 pg/mL
测定范围
8.2-2,000 pg/mL
检测样本类型/体积
{Serum=50 µL, Plasma=50 µL, Supernatant=50 µL}
手工操作时间
1 hr 20 min
总时间
4 hr 45 min
均相（无需洗涤）
No
批间差异
<12%
批内差异
<10%
检测仪器
Absorbance Microplate Reader
产品规格
96 Tests
产品成分
Pre-coated 96 well plate
Standard
Assay Diluent concentrate
Biotinylated Detection Antibody
SAV-HRP
Wash Buffer
Chromogen
Stop Solution
Adhesive Plate Covers
Standard
Assay Diluent concentrate
Biotinylated Detection Antibody
SAV-HRP
Wash Buffer
Chromogen
Stop Solution
Adhesive Plate Covers
运输条件
Wet ice
储存
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C
蛋白名称
FAS (CD95)
均相（无需洗涤）
Mouse
检测试剂盒格式
Sandwich ELISA Kit
检测抗体结合物
Biotin
标签或染料
HRP
关于本试剂盒
Mouse FAS/TNFRSF6/Apo-1 quantitates mouse FAS/TNFRSF6/Apo-1 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse FAS/TNFRSF6/Apo-1.
靶标信息
CD95, also known as Fas or APO-1, is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor in the tumor necrosis factor receptor (TNFR) superfamily. It is expressed by a wide range of hematopoietic and non-hematopoietic cells, including monocytes, neutrophils, lymphocytes, and fibroblasts. CD95 also exists in a soluble form weighing approximately 26 kDa. The interaction of CD95 with its ligand, FasL, induces apoptosis, playing a crucial role in peripheral tolerance and anti-viral immune responses. Upon stimulation, CD95 leads to the aggregation of its intracellular Fas-associated death domains (FADD), formation of the death-inducing signaling complex (DISC), and activation of caspases. This cascade results in apoptosis. CD95 is also involved in activating NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and transduces proliferative signals in normal diploid fibroblasts and T cells. There are at least eight alternatively spliced transcript variants encoding seven distinct isoforms of CD95. Isoforms lacking the transmembrane domain may negatively regulate apoptosis mediated by the full-length isoform. The Fas/Fas ligand system is implicated in several human diseases, including AIDS, hepatitis, and cancer, highlighting its importance in immune regulation and disease pathology.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
基因别名 : AI196731, APO1, APT1, CD95, Fas, lpr, TNFR6, Tnfrsf6
基因ID : (Mouse) 14102
基因符号 : Fas
蛋白别名 : Apo-1 antigen, Apo1 antigen, Apo-1 Fas, OTTHUMP00000020045, OTTHUMP00000020046, OTTHUMP00000020051, OTTHUMP00000059646, Apoptosis-mediating surface antigen FAS, CD95, Fas (TNF receptor superfamily member), Fas antigen, FASLG receptor, lymphoproliferation, Tumor necrosis factor receptor superfamily member 6
UniProt ID (Mouse) P25446
