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Rat OPN quantitates rat OPN in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant rat OPN.
Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : 2AR, 2b7, Apl-1, BNSP, Bsp, BSPI, Eta, ETA-1, OP, Opn, Opnl, OSP, Ric, Spp-1, Spp1
基因ID : (Mouse) 20750, (Rat) 25353
基因符号 : Spp1, Spp1
蛋白别名 : 2AR, 44 kDa bone phosphoprotein, Bone sialoprotein 1, Bone sialoprotein 1 (BSPI/BSP1), CALPHA1 fusion, Early T lymphocyte activation 1 (ETA1), HGNC:11255, immunoglobulin alpha 1 heavy chain constant region fusion protein, MGC110940, secreted phosphoprotein 1 (osteopontin bone sialoprotein I early T lymphocyte activation 1), Secreted phosphoprotein 1 (SPP1), urinar, Calcium oxalate crystal growth inhibitor protein, Early T-lymphocyte activation 1 protein, Minopontin, Osteopontin, osteopontin-like protein, Secreted phosphoprotein 1, Sialoprotein (osteopontin), SPP-1
UniProt ID (Mouse) P10923, (Rat) P08721