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Rat DKK-1 quantitates rat DKK-1 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant rat DKK-1.
DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head-forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play important regulatory roles in the Wnt/beta-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/beta-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/beta-catenin signaling cascade. It has been suggested that by inhibiting Wnt/beta-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因ID : (Rat) 293897
基因符号 : Dkk1
蛋白别名 : dickkopf 1 homolog, dickkopf homolog 1, dickkopf-like protein 1, dickkopf-related protein 1