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Rat HGF quantitates rat HGF in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant rat HGF.
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : Hgf, HPTA
基因ID : (Rat) 24446
基因符号 : Hgf
蛋白别名 : Hepatocyte growth factor, hepatopoeitin-A, Hepatopoietin-A, Scatter factor, SF
UniProt ID (Rat) P17945