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Invitrogen
Human ST2 (IL-33R) ELISA Kit
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产品规格
检测灵敏度
4.6 pg/mL
测定范围
4.7-300 pg/mL
检测样本类型/体积
{Cell Lysate=10 µL, Plasma=10 µL, Serum=10 µL}
手工操作时间
1 hr 20 min
总时间
3 hr 10 min
均相（无需洗涤）
No
批间差异
3.5%
批内差异
4.5%
检测仪器
Absorbance Microplate Reader
产品规格
96 Tests
产品成分
Pre-coated 96 well plate
Standard (2 vials)
Sample Diluent
Assay Buffer concentrate
Biotinylated Detection Antibody
Streptavidin-HRP
Wash Buffer
Substrate Solution
Stop Solution
Adhesive Plate Covers
Standard (2 vials)
Sample Diluent
Assay Buffer concentrate
Biotinylated Detection Antibody
Streptavidin-HRP
Wash Buffer
Substrate Solution
Stop Solution
Adhesive Plate Covers
运输条件
Wet ice
储存
2-8°C
蛋白名称
ST2
Target sub-specificity
Soluble
蛋白家族
Cytokine Receptor
均相（无需洗涤）
Human
检测试剂盒格式
Sandwich ELISA Kit
检测抗体结合物
Biotin
标签或染料
HRP
关于本试剂盒
The Human ST2 (IL-33R) ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative detection of human ST2 (IL-33R).
靶标信息
IL-33R, also known as ST2, is a receptor for IL-33. It is a member of the IL-1 receptor family of innate receptors. Its extracellular domain consists of 3 Ig-like domains that directly interact with its co-receptor IL-1RAcP, and the ligand alarmin, IL-33. IL-33 ligation results in the association of IL-33R complex with its adaptor proteins MyD88, IRAK1, IRAK4 and TRAF6, and activation of the NF-kB, and MAPK pathways. This, in turn, instigates the release of chemokines and cytokines such as IL-5, IL-6, IL-8, and IL-13. Two most common isoforms of IL-33R that result from alternative splicing are ST2L - the membrane bound form, and ST2S - the soluble form. The membrane bound form can be released from the cell surface by proteolytic cleavage. The soluble forms have been suggested to act as decoys dampening the IL-33 signaling. IL-33R is primarily expressed by mast cells, basophils, and eosinophils. In mouse, IL-33R expression has been shown on ILC2 and Th2 cells. IL-33R signaling has been implicated in the number of immune conditions, including allergies, arthritis, atherosclerosis and sepsis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
基因别名 : DER4, FIT-1, IL1RL1, IL33R, ST2, ST2L, ST2V, T1
基因ID : (Human) 9173
基因符号 : IL1RL1
蛋白别名 : DER4, Fit-1, IL-1 R4, IL1R4, IL-1R4, IL-1RL1, IL-33R, Ly84, ST2, ST2L, ST2V, suppression of tumorigenicity 2, T1, Interleukin1 receptor like 1, sIL 33R, soluble IL 33 Receptor, soluble IL 33R, growth stimulation-expressed, homolog of mouse growth stimulation-expressed, interleukin 1 receptor-like 1, interleukin 1 receptor-related protein, Interleukin-1 receptor-like 1, Protein ST2
UniProt ID (Human) Q01638
