Over the past few years, cryo-electron microscopy (cryo-EM) has positioned itself as an invaluable tool for the pharmaceutical industry. Numerous advancements increased the efficiency, ease-of-use, and throughput of the workflow, allowing structural biology to support the study of previously intractable biological targets. Structural insights are now being seen on membrane proteins (60% of drug targets) and large macromolecular complexes, that where not suitable for traditional techniques such as X-ray crystallography (XRD) and nuclear magnetic resonance (NMR) spectroscopy. Cryo-EM can accelerate structure-based drug design by providing a broader picture of how proteins function, revealing binding sites, conformations, and assisting with hit finding.
Cryo-EM Drug Discovery eBooks
Created specifically for pharmaceutical scientists, these eBooks provide information, videos, and supporting case studies.
Cryo-EM Trends for Drug Discovery eBook
Find a selection of case studies supported by cryo-EM:
- Antibody neutralization of Zika and Dengue
- Coronavirus SARS-CoV-2 spike protein, from sequence to structure in 4 weeks
- Driving structure-based drug design with cryo-EM
- And more
Reach the Targets of Drug Discovery eBook
Learn how to bring cryo-EM in house:
- Cryo-EM for small-molecule structure-based drug design
- Efficient cryo-EM sample optimization workflows
- Easy-to-use Cryo-TEM to improve and accelerate drug discovery process on time and on budget
- In-house cryo-EM adoption plans