Reveal the underlying physiological mechanisms

Preclinical image analysis relies on augmenting structural information from micro-CT or MRI systems with functional data from PET, SPECT or optical imaging instrumentation. Analysis of novel drug candidates requires pinpointing the location of dynamic processes acquired with functional modalities in images of the animal’s anatomy from structural modalities over time.
Amira Software enables the fusion of any type of preclinical image data. Co-registered images can be segmented and analyzed using Amira Software’s vast library of image analysis filters and algorithms. Image segmentation and quantification workflows can be applied to entire time series of image data of dynamic processes. With Amira Software’s professional-grade visualization tools, structural information from CT and MRI can be augmented and rendered jointly with segmentation results and functional images to create visualization of physiological processes that reveal the underlying mechanisms in an intuitive animation.


Imaging data

Workflow using Avizo Software

Processing

Workflow using Avizo Software

Visualization

Workflow using Avizo Software

Analysis

Workflow using Avizo Software
定制

可靠

凭借功能 强大的 分割和 图像 处理能力 与工作流程以及与科学界和数千名研究人员超过  20 年 的合作, 现已证明,我们基于数字成像的工作流程为 生物医学和生命科学研究提供了 可靠解决方案。

定制

定制

由于您的需求独一无二且不断变化,我们的软件解决方案非常灵活并且可以定制。借助我们的脚本编写界面(Python、TCL)、与 MATLAB 桥接以及编程 API,您可以扩展我们的软件解决方案并整合您自己的 IP(知识产权)。如果需要,我们的专业服务团队可以帮助设计符合您需求的独特解决方案。

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相关支持

感谢我们专业的支持团队,您可以与我们的顶尖专家取得联系,以确保所有问题得到解答。通过我们的培训、咨询选项 和不断扩充的教程集和操作方法,您可以缩短学习曲线,集中精力获得 所需的答案。

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自动化

凭借我们 的自动化功能以及新增的 不断扩充 的在线 插件存储库 (Xtra 库),您可以将 可重复 工作流程封装成易于再现的 方法流程。通过增加 人工智能,非图像处理专家 可以 高效地进行分析, 从而 节省 其在 复杂 分析上花费的时间, 同时 确保结果的 一致性。

Use cases

Insight from your peers

Explore industry-leading insights and research that can support your lab workflow. Amira Software can empower your lab with a cutting-edge, comprehensive imaging data analysis toolbox.

Helping scientists answer questions that enable breakthrough discoveries in life sciences, materials science, and industry.

Correlative Microscopy: Using Amira Software to Understand the Spread of Cancer
Read more
Amira Software Accelerates Veterinary Research with 3D Visualization and Analysis
Read more
Molecular Clarity—Discovering What’s Possible with Cryo-Electron Tomography
Read more
Cryo-Electron Tomography and 3D Software Advances Coronavirus Research
Read more

 

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Techniques

Co-registration

One of the main reasons researchers are using preclinical imaging is in vivo distribution studies aimed at localizing therapeutic agents in drug or gene therapy. These agents are often tagged or made susceptible for tagging with radioactive nuclei for detection with PET or SPECT imaging instruments.

With its extensive, performance-optimized registration tools and its multi-volume architecture, Amira Software allows preclinical researchers to automatically co-register image data from any type of preclinical imaging instrumentation. Amira Software’s extensive toolbox of segmentation and quantification tools then allows for segmentation of the anatomical images and quantifying radiotracer uptake in the co-registered functional images.

 

Bone separation

Micro-CT image acquisition is one of the most popular imaging techniques for any type of bone research. One of the first steps for any bone analysis is bone segmentation and separation into individual bones.

Amira Software offers the tools to perform bone segmentation from the surrounding tissue. The segmented bones can then be separated with Amira Software’s advanced algorithms. The individual bones can then be measured using a customizable list of the many measurements that Amira Software provides, such as size, shape and orientation.

 

Cell detection

Cellular spheroids are 3D cell cultures that represent in vivo tissue better than traditional cellular monolayers, improving the ability of researchers to study cancer, diabetes mellitus, or stem cells among many applications.

However, cell analysis in such 3D multicellular objects is not accurately possible, especially without destroying the object of study. Amira Software can automatically separate the cells and perform volumetric, morphometric, and intensity measurements on individual cells and their nuclei in 3D image data of these spheroids. Amira Software also helps researchers with the analysis of conventional 2D cellular monolayers.

 

Correlative imaging

With its long-standing applications in multi-modality imaging techniques, Amira Software is the tool of choice for many researchers working with data from different imaging modalities. Amira Software’s architecture supports multi-volume data processing and visualization from the ground up.

The automatic registration tools integrated into the standard edition of Amira Software with the Multi-Planar Workroom offer the flexibility of the most commonly used automated registration metrics and optimizers. These allow for the adjustment of the registration parameters to meet the needs of your data.

 

Membrane detection

Amira Software accelerates segmentation by employing automated detection of cellular features, such as filaments and membranes.

By performing advanced image analysis and statistics on the cryo-tomograms, Amira Software combines data from these individual structures, averaging out noise and increasing contrast to create a composite model with higher resolution.

 

Co-registration

One of the main reasons researchers are using preclinical imaging is in vivo distribution studies aimed at localizing therapeutic agents in drug or gene therapy. These agents are often tagged or made susceptible for tagging with radioactive nuclei for detection with PET or SPECT imaging instruments.

With its extensive, performance-optimized registration tools and its multi-volume architecture, Amira Software allows preclinical researchers to automatically co-register image data from any type of preclinical imaging instrumentation. Amira Software’s extensive toolbox of segmentation and quantification tools then allows for segmentation of the anatomical images and quantifying radiotracer uptake in the co-registered functional images.

 

Bone separation

Micro-CT image acquisition is one of the most popular imaging techniques for any type of bone research. One of the first steps for any bone analysis is bone segmentation and separation into individual bones.

Amira Software offers the tools to perform bone segmentation from the surrounding tissue. The segmented bones can then be separated with Amira Software’s advanced algorithms. The individual bones can then be measured using a customizable list of the many measurements that Amira Software provides, such as size, shape and orientation.

 

Cell detection

Cellular spheroids are 3D cell cultures that represent in vivo tissue better than traditional cellular monolayers, improving the ability of researchers to study cancer, diabetes mellitus, or stem cells among many applications.

However, cell analysis in such 3D multicellular objects is not accurately possible, especially without destroying the object of study. Amira Software can automatically separate the cells and perform volumetric, morphometric, and intensity measurements on individual cells and their nuclei in 3D image data of these spheroids. Amira Software also helps researchers with the analysis of conventional 2D cellular monolayers.

 

Correlative imaging

With its long-standing applications in multi-modality imaging techniques, Amira Software is the tool of choice for many researchers working with data from different imaging modalities. Amira Software’s architecture supports multi-volume data processing and visualization from the ground up.

The automatic registration tools integrated into the standard edition of Amira Software with the Multi-Planar Workroom offer the flexibility of the most commonly used automated registration metrics and optimizers. These allow for the adjustment of the registration parameters to meet the needs of your data.

 

Membrane detection

Amira Software accelerates segmentation by employing automated detection of cellular features, such as filaments and membranes.

By performing advanced image analysis and statistics on the cryo-tomograms, Amira Software combines data from these individual structures, averaging out noise and increasing contrast to create a composite model with higher resolution.

 

Services

Amira-Avizo-Introductory-training_1160x600

入门培训

通过专门为 Amira、Avizo 和 PerGeos 软件新用户设计的入门培训,缩短学习曲线,使投资收益最大化。

课程包括一个讲座及互动提问环节。培训材料重点讲述 Amira、Avizo 和 PerGeos 软件的基本特点和功能。

Amira-Avizo-advanced-training_1160x600

高级培训

通过专为 Amira、Avizo 和 PerGeos 软件的现有用户设计的高级培训使投资收益最大化并缩短取得成果的时间。

课程包括一个讲座及互动提问环节。培训材料重点讲述 Amira、Avizo 和 PerGeos 软件的高级特点和功能。

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定制开发

赛默飞世尔科技在 3D 和图像处理方面拥有超过 25 年的经验,向众多小型和大型机构交付了数百个定制项目,可根据您的特定需求为您提供量身定制的解决方案。

我们可以定制和扩展我们不同级别的软件解决方案。


Testimonials

VetCore, University of Veterinary Medicine uses Amira Software

"Research at Vetmeduni Vienna is quite diverse, covering both clinical and preclinical research areas. We are currently four people working in the imaging facility, providing equipment and supports for researchers in both image acquisition (widefield microscopy, CLSM, spinning disk confocal microscopy, soon also STORM super-resolution microscopy, microscopic X-ray computed tomography) and in data visualization and analysis. Amira Software allows you to build networks, enabling complex interactions between data objects. Biology is also complex, and biological interactions are complex networks. Complex questions require complex tools to address them. In this respect, analysis networks such as used in Amira Software outperform most other software approaches when it comes to complex data analysis. Furthermore, I like that Amira Software is quite open concerning integration of deep learning networks and scripting (Tcl, Matlab, Python,...)."

Stephan Handschuch, PhD
VetCore, University of Veterinary Medicine, Vienna



Resources

Understanding the passage of air through the upper airways is crucial for planning corrective rhinosurgery when undisturbed airflow is inhibited by persistent obstructions or deformities.

Micro-CT image acquisition is one of the most popular imaging techniques for any type of bone research. One of the first steps for any bone analysis is bone segmentation and separation into individual bones.

Discover how Amira-Avizo Software enables the whole 3D printing workflow, from 2D image stack import, to 3D reconstruction and 3D meshing, right through to 3D printer compatible formats export. Data courtesy of National University of Singapore.

Amira Software can automatically count the cell nuclei which correspond to the cell count of the 3D spheroid cell cultures.

Amira-Software-Preclinical_1160x600_image-card
Maximum intensity projection and surface reconstruction of a mouse thorax. Acquisition device: VAMP TomoScope® 30s+, Amira Software - Courtesy of Dr. Elizatea Stepina and Dr. Peter Hauff, Bayer Healthcare.
Amira-Software-coregistration_1160x600_image-card


Co-registration for distribution studies. CT/SPECT data courtesy of Dr. Nabil Boutagy of the Yale Translation Research Imaging Center.

Amira-Software-bone-separation_1160x600_image-card
Courtesy of National Laboratory Animal Center - National Applied Research Laboratories, Taiwan.

Understanding the passage of air through the upper airways is crucial for planning corrective rhinosurgery when undisturbed airflow is inhibited by persistent obstructions or deformities.

Micro-CT image acquisition is one of the most popular imaging techniques for any type of bone research. One of the first steps for any bone analysis is bone segmentation and separation into individual bones.

Discover how Amira-Avizo Software enables the whole 3D printing workflow, from 2D image stack import, to 3D reconstruction and 3D meshing, right through to 3D printer compatible formats export. Data courtesy of National University of Singapore.

Amira Software can automatically count the cell nuclei which correspond to the cell count of the 3D spheroid cell cultures.

Amira-Software-Preclinical_1160x600_image-card
Maximum intensity projection and surface reconstruction of a mouse thorax. Acquisition device: VAMP TomoScope® 30s+, Amira Software - Courtesy of Dr. Elizatea Stepina and Dr. Peter Hauff, Bayer Healthcare.
Amira-Software-coregistration_1160x600_image-card


Co-registration for distribution studies. CT/SPECT data courtesy of Dr. Nabil Boutagy of the Yale Translation Research Imaging Center.

Amira-Software-bone-separation_1160x600_image-card
Courtesy of National Laboratory Animal Center - National Applied Research Laboratories, Taiwan.

Features

导入和处理您的成像数据

    • 处理任何规模、任何大小及任何模态的数据:

    - 生物数据格式
    - 位图格式
    - 显微镜:电子和光学
    - 医学和神经图像格式
    - 分子格式
    - 其他图像采集设备(MRI、放射摄影术等)

    • 有限元建模、几何建模、CAD
    • 支持多数据/多视图、多通道、时间序列、超大数据
    • 缩放、校准、转换、重新采样
    • 图像增强、能满足各种需求的滤波和卷积、傅立叶变换
    • 伪影消除算法
    • 先进的多模式 2D/3D 自动配准
    • 图像对齐、算术运算、相关、融合

    轻松分割成像数据

    • 阈值和自动分割、对象分离、自动标记
    • 区域生长、活动轮廓、插值、卷绕、平滑
    • 形态学处理,包括分水岭和盆地
    • 基于机器学习的分割
    • 自动追踪单个纤维和丝状体
    • 骨架化和纤丝网络提取
    • 交互式工具,用于生成或编辑分割和空间图形
    • 3D 表面重建
    • FEA/CFD 载网生成

     

    导出您的分析和可视化工作以便无缝发布并演示

    • 动画和视频生成
    • 高级关键帧和物体动画
    • 混合图像、几何模型、测量和模拟
    • 注释、测量图例、柱状图和曲线图
    • 导出电子表格、3D 模型和高质量图像
    • 主动和被动 3D 立体视觉
    • 单屏和多屏显示
    • 沉浸式环境

    可视化和探索您的成像数据

    • 交互式高质量体渲染和多通道可视化
    • 正交、倾斜、圆柱形和弧形切面
    • 轮廓绘制和等值面提取
    • 最大信号或其他类型投影
    • 矢量和张量可视化
    • 对象和追踪
    • 分子可视化

    分析成像数据并获得定量信息

    • 直观的模板菜单创建、自定义、自动重放
    • 内置测量项目,包括计数、体积、面积、周长、长径比和方向
    • 用户定义的测量指标
    • 内含电子表格工具和图表的结果查看器
    • 自动单个特征测量、3D 定位和电子表格选择
    • 自动统计、分布图
    • 使用任何测量标准进行特征过滤
    • 数据配准、变形、比较和测量

     

    轻松、快速地调整 Amira 软件以满足您的特定需求

    • 定制 C++ 模块开发
    • MATLAB™ 桥
    • Python 脚本 API

    Contact us

    For Research Use Only. Not for use in diagnostic procedures.

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