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Due to its high performance in spatial resolution, TransMIT’s AP-SMALDI5 AF ion source is the perfect match for the high mass resolution and accurate mass (HRAM) capabilities of Thermo Scientific Orbitrap MS instrumentation. The coupling of AP-SMALDI5 AF and Orbitrap technologies enables high mass and spatial resolution by providing:
TransMIT Center for Mass Spectrometric Development (TransMIT GmbH, Giessen, Germany) offers integrated high-end solutions for atmospheric-pressure Scanning microprobe Matrix-Assisted Laser Desorption/Ionization (MALDI) mass spectrometric imaging. These solutions are based on TransMIT’s proprietary SMALDI MS Imaging and 3D-Surface MS Imaging technology.
The AP-SMALDI source generates ions under atmospheric pressure (AP) and the experimental setup allows to systematically scan tissue samples or 3D objects with the pulsed laser beam applying laser spot sizes of 5 μm routinely and without oversampling.
TransMIT’s SMALDIPrep device, its AP-SMALDI5 AF ion source, its Mirion MS Image generation software and Orbitrap Exploris MS instrumentation allows for spatial multi-omics analysis from tissue and from surfaces of 3D objects.
AP-SMALDI ion source schematic detail: (1) the laser beam passes through a focusing lens (2) two mirrors directing the light through an objective lens (3) close to the sample. The objective lens (3) focuses the pulsed laser light to the tissue sample base plate (4). An off-axis camera (5) allows for sample inspection while the autofocusing (6) laser ensures the analyzing laser is always in focus. Technical details of the AP-SMALDI5 AF setup coupled to Orbitrap mass spectrometry for MS Imaging application. Note: AP-SMALDI5 AF ion source is a laser class 1 product.
For Research Use Only. Not for use in diagnostic procedures.