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Studies of LRRK2 (leucine-rich repeat kinase 2) function and inhibition have been hampered by a lack of tools to express full-length LRRK2 in diverse cell types as well as high-throughput biochemical and cell-based assays.
Now, LRRK2 researchers can access full-length protein, HTS assays and BacMam particles from Life Technologies that can be used to identify compounds that inhibit kinase activity in WT-LRRK2, the Parkinson’s disease-associated G2019S and other variants.
Poster: Express Full-Length LRRK2 and Profile Inhibitors using Cell-Based and Biochemical Assays
SKU | LRRK2 Reagents | Amino Acids | Tag | Biochemical Activity Assays | Biochemical Binding Assays | Cellular Assays | Ordering Information |
---|---|---|---|---|---|---|---|
PV4873 | LRRK2 protein | 970-2527 | GST | Order | |||
A13388 | BacMam LRRK2 | 1 - 2527 | |||||
A14170 | BacMam LRRK2-GFP | 1 - 2527 | GFP |
| |||
A14171 | LRRK2-GFP Lysate | 1 - 2527 | GFP | Order | |||
A14685 | Lanthascreen LRRK2 (pSer935) Cellular assay kit | 1 - 2527 | GFP | ||||
A15197 | LRRK2 WT Full Length Protein (10 µg) | 1-2527 | DYKDDDDK | Order | |||
A15198 | LRRK2 WT Full Length Protein (100 µg) | 1-2527 | DYKDDDDK | Order | |||
A15199 | LRRK2 WT Full Length Protein (1 mg) | 1-2527 | DYKDDDDK | Order |
SKU | LRRK2 Reagents | Amino Acids | Tag | Biochemical Activity Assays | Biochemical Binding Assays | Cellular Assays | Ordering Information |
---|---|---|---|---|---|---|---|
PV4881 | LRRK2 G2019S | 970-2527 | GST | Order | |||
A13389 | BacMam LRRK2 G2019S | 1 - 2527 | |||||
A14174 | BacMam LRRK2-GFP G2019S | 1 - 2527 | GFP |
|
| ||
A14172 | LRRK2-GFP G2019S Lysate | 1 - 2527 | GFP | Order | |||
A14686 | Lanthascreen LRRK2 G2019S (pSer935) Cellular assay kit | 1 - 2527 | GFP |
| |||
A15200 | LRRK2 WT Full Length Protein (10 µg) | 1-2527 | DYKDDDDK |
| Order | ||
A15201 | LRRK2 WT Full Length Protein (100 µg) | 1-2527 | DYKDDDDK | Order | |||
A15202 | LRRK2 WT Full Length Protein (1 mg) | 1-2527 | DYKDDDDK | Order |
SKU | LRRK2 Reagents | Amino Acids | Tag | Biochemical Activity Assays | Biochemical Binding Assays | Cellular Assays | Ordering Information |
---|---|---|---|---|---|---|---|
PV6051 | LRRK2 D1994A protein | 970-2527 | GST |
Kinase "Dead" engineered Mutation (useful as a control) |
| Order | |
A13390 | BacMam LRRK2 D1994A | 1 - 2527 | |||||
Please inquire | BacMam LRRK2-GFP D1994A | 1 - 2527 | GFP |
|
SKU | LRRK2 Reagents | Amino Acids | Tag | Biochemical Activity Assays | Biochemical Binding Assays | Cellular Assays | Ordering Information |
---|---|---|---|---|---|---|---|
PV4873 | LRRK2 protein | 970-2527 | GST | Order | |||
A13388 | BacMam LRRK2 | 1 - 2527 | |||||
A14170 | BacMam LRRK2-GFP | 1 - 2527 | GFP |
| |||
A14171 | LRRK2-GFP Lysate | 1 - 2527 | GFP | Order | |||
A14685 | Lanthascreen LRRK2 (pSer935) Cellular assay kit | 1 - 2527 | GFP | ||||
A15197 | LRRK2 WT Full Length Protein (10 µg) | 1-2527 | DYKDDDDK | Order | |||
A15198 | LRRK2 WT Full Length Protein (100 µg) | 1-2527 | DYKDDDDK | Order | |||
A15199 | LRRK2 WT Full Length Protein (1 mg) | 1-2527 | DYKDDDDK | Order |
SKU | LRRK2 Reagents | Amino Acids | Tag | Biochemical Activity Assays | Biochemical Binding Assays | Cellular Assays | Ordering Information |
---|---|---|---|---|---|---|---|
PV4881 | LRRK2 G2019S | 970-2527 | GST | Order | |||
A13389 | BacMam LRRK2 G2019S | 1 - 2527 | |||||
A14174 | BacMam LRRK2-GFP G2019S | 1 - 2527 | GFP |
|
| ||
A14172 | LRRK2-GFP G2019S Lysate | 1 - 2527 | GFP | Order | |||
A14686 | Lanthascreen LRRK2 G2019S (pSer935) Cellular assay kit | 1 - 2527 | GFP |
| |||
A15200 | LRRK2 WT Full Length Protein (10 µg) | 1-2527 | DYKDDDDK |
| Order | ||
A15201 | LRRK2 WT Full Length Protein (100 µg) | 1-2527 | DYKDDDDK | Order | |||
A15202 | LRRK2 WT Full Length Protein (1 mg) | 1-2527 | DYKDDDDK | Order |
SKU | LRRK2 Reagents | Amino Acids | Tag | Biochemical Activity Assays | Biochemical Binding Assays | Cellular Assays | Ordering Information |
---|---|---|---|---|---|---|---|
PV6051 | LRRK2 D1994A protein | 970-2527 | GST |
Kinase "Dead" engineered Mutation (useful as a control) |
| Order | |
A13390 | BacMam LRRK2 D1994A | 1 - 2527 | |||||
Please inquire | BacMam LRRK2-GFP D1994A | 1 - 2527 | GFP |
|
indicates reagents have been shown to work in assays. Biochemical assays include Adapta®, LanthaScreen® activity and Eu-kinase binding assays. Cellular assays include localization and activity assays measuring Ser935 phosphorylation. For specific assay functionality details, click the linked SKU numbers.
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For Research Use Only. Not for use in diagnostic procedures.
仅供科研使用,不可用于诊断目的。