Fluorescent iPSC colony generated via CytoTune Sendai reprogramming.

从体细胞生成诱导多能干细胞 (iPSC) 不再是一项艺术；在 CytoTune-iPS 仙台病毒iPSC重编程试剂盒的帮助下它已然成为一门可以被预测的科学。直接从具有不同遗传背景的多种细胞类型（包括 PBMS 和 T 细胞）衍生细胞系我们的 CytoTune-iPS 2.0 仙台病毒重编程试剂盒可支持最为领先的基础研究，而我们的 CTS CytoTune 2.1 仙台病毒重编程试剂盒则有助于临床及转化研究。无论您处在过程中的哪一步，我们都可提供能支持您从研究直至商品化的重编程工具。

为何使用仙台病毒进行 iPSC 重编程？

  • 在多种细胞类型中具有较高的重编程效率
  • 无整合递送降低了基因组风险
  • 适用于疾病建模和转化研究
  • 与基于质粒的方法相比，具有更好的可重复性和可扩展性


仙台病毒重编程与其他方法相比如何？

  • 仙台病毒：高效率、无整合、瞬时RNA
  • 维持型载体：无整合，但效率较低
  • mRNA重编程：无整合，需要每日转染
  • 慢病毒方法：高效率但会整合入基因组


CytoTune iPS 2.0 仙台病毒重编程试剂盒——在非整合型重编程技术中成功率较高

  • 对成纤维细胞和血液重编程均具有最高成功率
  • 用最少的手动操作时间完成可扩展的细胞系生成
  • RNA 载体清除迅速


CTS CytoTune-iPS 2.1 仙台病毒重编程试剂盒——高效过渡至临床应用

  • 根据 GMP 的规定生产
  • 不含动物源成分
  • 附带监管支持文件（RSF），以支持您的监管申报


CytoTune Sendai 重编程试剂盒订购信息


使用 CytoTune-iPS 试剂盒减少动手操作时间

下图展示了使用 CytoTune-iPS 2.0 Sendai 重编程试剂盒对人新生儿包皮成纤维细胞进行重编程，以生成在 MEF 饲养层细胞上培养的 iPSC 所需的主要步骤。

下图展示了使用 CytoTune-iPS 2.0 Sendai 重编程试剂盒将外周血单个核细胞（PBMC）重编程并在 MEF 饲养层细胞上培养以生成 iPSC 所需的主要步骤。

使用 CytoTune-iPS Sendai 重编程试剂盒从人新生儿包皮成纤维细胞（BJ 株）简单生成 iPSC 克隆

A. 转导前的成纤维细胞

B. 转导后 2 周

C. 转导后 3 周

D. 手工挑取并扩增后

(A) 转导前的成纤维细胞。(B-D) 使用 CytoTune-iPS 2.0 Sendai 重编程试剂盒单次处理后，转导后 (B) 2 周和 (C) 3 周的 iPSC 克隆可因重编程效率高且部分重编程细胞背景低而被轻松识别。(D) 手动挑取并转移至 KnockOut SR 培养基后的 iPSC 克隆。

比较工作流程

使用 CytoTune 2.0 试剂盒进行一次转导后，可在 3–4 周内生成 iPSC；而 mRNA 方法需要连续 18 天的转导。传统重编程方法（如慢病毒）可能需要多次转导才能生成 iPSC。

查看实验流程时间表

下图展示了使用 CytoTune-iPS 2.0 Sendai 重编程试剂盒对人新生儿包皮成纤维细胞进行重编程，以生成在 MEF 饲养层细胞上培养的 iPSC 所需的主要步骤。

下图展示了使用 CytoTune-iPS 2.0 Sendai 重编程试剂盒将外周血单个核细胞（PBMC）重编程并在 MEF 饲养层细胞上培养以生成 iPSC 所需的主要步骤。

见 iPSC 克隆的生成

使用 CytoTune-iPS Sendai 重编程试剂盒从人新生儿包皮成纤维细胞（BJ 株）简单生成 iPSC 克隆

A. 转导前的成纤维细胞

B. 转导后 2 周

C. 转导后 3 周

D. 手工挑取并扩增后

(A) 转导前的成纤维细胞。(B-D) 使用 CytoTune-iPS 2.0 Sendai 重编程试剂盒单次处理后，转导后 (B) 2 周和 (C) 3 周的 iPSC 克隆可因重编程效率高且部分重编程细胞背景低而被轻松识别。(D) 手动挑取并转移至 KnockOut SR 培养基后的 iPSC 克隆。


直接从血细胞生成 iPSC

iPS colonies in 4 different cell culture dishes made visible via alkaline phosphatase staining.

重编程克隆。使用CytoTune 2.0 试剂盒从不同体细胞来源制备诱导多能干细胞 (iPSC)，并使用Essential 8 培养基在无饲养层条件下培养。


在广泛的实验中使用 CytoTune-iPS 试剂盒

点击下方选项卡，了解基因组无整合及无病毒残留如何使 CytoTune 可用于广泛的实验，包括疾病研究。

CytoTune - EmGFP Sendai 荧光报告基因

BJ HDFn 细胞以 MOI=5 转导 CytoTune™-EmGFP Sendai Fluorescence Reporter，48 小时后的成像结果。绿色荧光信号表明仙台病毒已被细胞摄取。

来自多种体细胞类型的成功 iPSC 重编程

以下体细胞类型已使用 CytoTune 技术成功重编程为 iPSC。

  • 成人和新生儿真皮成纤维细胞
  • 羊水 MSCs
  • 心脏成纤维细胞
  • CD34+ 血细胞
  • 乳腺上皮细胞
  • 鼻腔上皮细胞
  • 外周血单核细胞（PBMCs）
  • 骨骼肌母细胞
  • T细胞
  • 脐静脉上皮细胞
  • 尿道上皮细胞

非整合型 Sendai 载体与整合型载体的生命周期比较

Diagram comparing Sendai virus vector vs other vectors for cytoplasmic expression without genome integration

Sendai 病毒（SeV）是一种直径为 150–250 nm 的有包膜病毒，其基因组为单链负义 RNA。野生型 SeV 基因组上顺序排列着编码病毒蛋白的六个基因，顺序如下。

核衣壳蛋白（NP）与基因组 RNA 形成核心核衣壳复合物。磷蛋白（P）是 RNA 聚合酶的小亚基。基质蛋白（M）从内部支撑包膜结构。当病毒进入细胞时，融合蛋白（F）使病毒包膜与细胞膜融合。编码 F 蛋白的基因已从 CytoTune-iPS Sendai 重编程试剂盒载体中删除，因此其无法在感染细胞中产生感染性颗粒。

血凝素-神经氨酸酶（HN）识别细胞表面受体——唾液酸。大蛋白（L）是 RNA 聚合酶的大亚基。

由于 SeV 通过与存在于多种不同细胞表面的唾液酸受体结合而感染细胞，因此它可以感染不同动物的多种细胞类型。病毒-细胞融合过程的发生需要蛋白 F 经蛋白酶激活。感染后，病毒在细胞质中进行基因组复制和蛋白质合成，随后子代病毒颗粒被组装并释放。

其他病毒载体，如慢病毒或逆转录病毒，复制时需要整合到宿主基因组中，因此可能会破坏被重编程细胞的基因组，使 iPSCs 及其衍生物在临床应用中不够安全，或改变基因表达模式，从而影响化合物筛选或疾病通路分析。使用 CytoTune-iPS Sendai 重编程试剂盒进行一次转导即可高效生成 iPSCs，且无基因组整合或病毒残留，从而使 iPSCs 及其衍生物可用于更广泛的研究实验。


CytoTune-iPS 试剂盒的技术资源

Product photo of CytoTune-iPS Kit

查看我们关于使用仙台病毒进行重编程的技术资源。我们提供了详细的操作规程和常见问题解答，以及技术视频，帮助您顺利完成 CytoTune 重编程之旅。

CytoTune-iPS 2.0 Sendai 重编程试剂盒

技术资源名称
方案使用 CytoTune-iPS 2.0 Sendai重编程试剂盒生成 hiPSCs
（包括在依赖饲养层和无饲养层环境中的成纤维细胞、PBMCs 和 CD34+ 细胞）
用户指南CytoTune-iPS 2.0Sendai 重编程试剂盒用户指南
（包括成纤维细胞、PBMCs 和 CD34+ 细胞重编程方案）
常见问题CytoTune-iPS 2.0 重编程试剂盒常见问题解答

向专家学习

视频 1：仙台病毒如何重编程细胞？

本视频演示了 CytoTune-iPS 仙台病毒重编程试剂盒中的仙台病毒如何将体细胞重编程为诱导多能干细胞（iPSCs）。

视频 2：Mark Tomishima 博士谈“将一切不确定性降到最低”

Sloan Kettering Institute 干细胞研究设施的 Mark Tomishima 博士介绍了其实验室如何不断改进利用不改变基因组的仙台病毒载体对细胞进行重编程的方法。这项技术可用于制备不含随机插入 DNA 的工程化 iPSC 细胞系。

视频 3：Uma Lakshmipathy 博士介绍无转基因诱导多能干细胞的生成

Uma Lakshmipathy 博士介绍了使用 CytoTune-iPS 仙台病毒重编程试剂盒，以高效率借助仙台病毒创建无整合诱导多能干细胞的工作。

视频4：思想领袖的视角——利用 iPS 细胞揭示心血管疾病

哈佛科学家 Chad Cowan 博士借助由 CytoTune 技术驱动的 iPS 细胞技术，推动糖尿病和心脏病研究的新发现。

Sendai 病毒适用于您的细胞吗？

CytoTune - EmGFP Sendai 荧光报告基因

BJ HDFn 细胞以 MOI=5 转导 CytoTune™-EmGFP Sendai Fluorescence Reporter，48 小时后的成像结果。绿色荧光信号表明仙台病毒已被细胞摄取。

来自多种体细胞类型的成功 iPSC 重编程

以下体细胞类型已使用 CytoTune 技术成功重编程为 iPSC。

  • 成人和新生儿真皮成纤维细胞
  • 羊水 MSCs
  • 心脏成纤维细胞
  • CD34+ 血细胞
  • 乳腺上皮细胞
  • 鼻腔上皮细胞
  • 外周血单核细胞（PBMCs）
  • 骨骼肌母细胞
  • T细胞
  • 脐静脉上皮细胞
  • 尿道上皮细胞
查看 Sendai 检测方法

查看终点 PCR 和染色

缺乏基因组整合和病毒残留，使得 CytoTune-iPS Sendai 重编程试剂盒可用于广泛的实验，包括疾病研究。

(A) 使用 TaqMan-iPSC Sendai 检测试剂盒监测转基因和 Sendai 病毒清除情况的扩增曲线图。

(B) 抗 Sendai 抗体的免疫荧光染色，显示使用 CytoTune 试剂盒生成的 iPSC 克隆中不存在 Sendai 病毒。

了解 Sendai 的工作原理

非整合型 Sendai 载体与整合型载体的生命周期比较

Diagram comparing Sendai virus vector vs other vectors for cytoplasmic expression without genome integration

Sendai 病毒（SeV）是一种直径为 150–250 nm 的有包膜病毒，其基因组为单链负义 RNA。野生型 SeV 基因组上顺序排列着编码病毒蛋白的六个基因，顺序如下。

核衣壳蛋白（NP）与基因组 RNA 形成核心核衣壳复合物。磷蛋白（P）是 RNA 聚合酶的小亚基。基质蛋白（M）从内部支撑包膜结构。当病毒进入细胞时，融合蛋白（F）使病毒包膜与细胞膜融合。编码 F 蛋白的基因已从 CytoTune-iPS Sendai 重编程试剂盒载体中删除，因此其无法在感染细胞中产生感染性颗粒。

血凝素-神经氨酸酶（HN）识别细胞表面受体——唾液酸。大蛋白（L）是 RNA 聚合酶的大亚基。

由于 SeV 通过与存在于多种不同细胞表面的唾液酸受体结合而感染细胞，因此它可以感染不同动物的多种细胞类型。病毒-细胞融合过程的发生需要蛋白 F 经蛋白酶激活。感染后，病毒在细胞质中进行基因组复制和蛋白质合成，随后子代病毒颗粒被组装并释放。

其他病毒载体，如慢病毒或逆转录病毒，复制时需要整合到宿主基因组中，因此可能会破坏被重编程细胞的基因组，使 iPSCs 及其衍生物在临床应用中不够安全，或改变基因表达模式，从而影响化合物筛选或疾病通路分析。使用 CytoTune-iPS Sendai 重编程试剂盒进行一次转导即可高效生成 iPSCs，且无基因组整合或病毒残留，从而使 iPSCs 及其衍生物可用于更广泛的研究实验。


CytoTune-iPS 试剂盒的技术资源

Product photo of CytoTune-iPS Kit

查看我们关于使用仙台病毒进行重编程的技术资源。我们提供了详细的操作规程和常见问题解答，以及技术视频，帮助您顺利完成 CytoTune 重编程之旅。

文档

CytoTune-iPS 2.0 Sendai 重编程试剂盒

技术资源名称
方案使用 CytoTune-iPS 2.0 Sendai重编程试剂盒生成 hiPSCs
（包括在依赖饲养层和无饲养层环境中的成纤维细胞、PBMCs 和 CD34+ 细胞）
用户指南CytoTune-iPS 2.0Sendai 重编程试剂盒用户指南
（包括成纤维细胞、PBMCs 和 CD34+ 细胞重编程方案）
常见问题CytoTune-iPS 2.0 重编程试剂盒常见问题解答
视频

向专家学习

视频 1：仙台病毒如何重编程细胞？

本视频演示了 CytoTune-iPS 仙台病毒重编程试剂盒中的仙台病毒如何将体细胞重编程为诱导多能干细胞（iPSCs）。

视频 2：Mark Tomishima 博士谈“将一切不确定性降到最低”

Sloan Kettering Institute 干细胞研究设施的 Mark Tomishima 博士介绍了其实验室如何不断改进利用不改变基因组的仙台病毒载体对细胞进行重编程的方法。这项技术可用于制备不含随机插入 DNA 的工程化 iPSC 细胞系。

视频 3：Uma Lakshmipathy 博士介绍无转基因诱导多能干细胞的生成

Uma Lakshmipathy 博士介绍了使用 CytoTune-iPS 仙台病毒重编程试剂盒，以高效率借助仙台病毒创建无整合诱导多能干细胞的工作。

视频4：思想领袖的视角——利用 iPS 细胞揭示心血管疾病

哈佛科学家 Chad Cowan 博士借助由 CytoTune 技术驱动的 iPS 细胞技术，推动糖尿病和心脏病研究的新发现。


引用用于 iPSC 生成的仙台病毒的出版物

使用 CytoTune-iPS 试剂盒的精选出版物

以下为主要文献引用列表（按年份排序）

Year细胞类型文献物种
2020Blood cellsDeslauriers A.G., et al. (2021) Modeling Leukemia Stem Cells with Patient-Derived Induced Pluripotent Stem Cells. In: Cobaleda C., Sánchez-García I. (eds) Leukemia Stem Cells. Methods in Molecular Biology, vol 2185. Humana, New York, NY人
2020Cells from placental artery endothelium (PL)Isono, W. et al. (2020) The combination of dibenzazepine and a DOT1L inhibitor enables a stable maintenance of human naïve-state pluripotency in non-hypoxic conditions. Regenerative Therapy Vol 15 December 2020, Pages 161-168人
2020CD34+ bone marrow cellsLee, S.-J et al. (2020) Supporting data on enhanced reprogramming of human CD34+ hematopoietic stem cells to induced pluripotent stem cells using human placenta-derived cell conditioned medium. Data in Brief Vol 32 October 2020, 106140人
2020FibroblastVasylovska, S. et al. Generation of human induced pluripotent stem cell (iPSC) lines (UUMCBi001-A, UUMCBi002-A) from two healthy donors. Stem Cell Res 9 December 2020, 102114 (online)人
2020PMBCLim, SW. et al. (2020) Generation of a human induced pluripotent stem cell line (CMCi002-A) from a patient with Gitelman’s syndrome. Stem Cell Res 4 December 2020, 102110 (online)人
2020PMBCChu, E.P-F. et al. (2020) Generation of three induced pluripotent stem cell lines from type 2 diabetic patients with ocular complications. Stem Cell Res Vol 49 December 2020, 102109人
2020PMBCBarnabei, L. et al. (2020) Generation of an iPSC line (IMAGINi011-A) from a patient carrying a STING mutation. Stem Cell Res 2 December 2020, 102107 (online) 人
2020PBMCBarbeau, S. et al. (2020) Generation of a human induced pluripotent stem cell line (iPSC) from peripheral blood mononuclear cells of a patient with a myasthenic syndrome due to mutation in COLQ. Stem Cell Res Vol 49 December 2020, 102106人
2020FibroblastBono, F. et al. (2020) Generation of two human induced pluripotent stem cell lines, UNIBSi012-A and UNIBSi013-A, from two patients with treatment-resistant depression. Stem Cell Res Vol 49 December 2020, 102104人
2020FibroblastDing, Y. et al. (2020) Derivation of iPSC lines from three young healthy donors of Caucasian origin (NUIGi035-A; NUIGi036-A; NUIGi037-A). Stem Cell Res Vol 49 December 2020, 102101人
2020PBMCYamasaki, AE. et al. (2020) An iPSC line derived from a human acute myeloid leukemia cell line (HL-60-iPSC) retains leukemic abnormalities and displays myeloid differentiation defects. Stem Cell Res Vol 49 December 2020, 102096人
2020PBMCSouidi, M. et al. (2020) Generation of three Duchenne Muscular Dystrophy patient-specific induced pluripotent stem cell lines DMD_YoTaz_PhyMedEXp, DMD_RaPer_PhyMedEXp, DMD_OuMen_PhyMedEXp (INSRMi008-A, INSRMi009-A and INSRMi010-A). Stem Cell Res Vol 49 December 2020, 102094人
2020PBMCYan, R. et al. (2020) Generation of a human induced pluripotent stem cell line (SBWCHi001-A) from a patient with NEDSDV carrying a pathogenic mutation in CTNNB1 gene. Stem Cell Res Vol 49 December 2020, 102091人
2020PBMCZhu, YJ. et al. (2020) Generation of an induced pluripotent stem cell line (PUMCHi006-A) derived from a patient with pulmonary arterial hypertension carrying heterozygous c.1339 G > A mutation in PTGIS gene. Stem Cell Res 49 December 2020, 102088人
2020Urine cellsGuo, X et al. (2020) Generation of an urine-derived induced pluripotent stem cell line from a 5-year old X-linked Alport syndrome (X-LAS) patient. Stem Cell Res Vol 49 December 2020, 102085人
2020FibroblastMukherjee, S. et al. (2020) Generation of human control iPSC line CHOPi004-A from juvenile foreskin fibroblast cells. Stem Cell Res Vol 49 December 2020, 102084人
2020FibroblastScalise, S. et al. (2020) Generation of iPSC lines from two patients affected by febrile seizure due to inherited missense mutation in SCN1A gene. Stem Cell Res Vol 49 December 2020, 102083人
2020FibroblastInglés-Ferrándiz, M. et al. (2020) Generation, establishment and characterization of a pluripotent stem cell line (CVTTHi001-A) from primary 成纤维细胞 isolated from a patient with activated PI3 kinase delta syndrome (APDS2). Stem Cell Res 49 December 2020, 102082人
2020FibroblastSchuster, J. et al. (2020) Generation of two human iPSC lines (UUIGPi013-A and UUIPGi014-A) from cases with Down syndrome and full trisomy for chromosome 21 (T21). Stem Cell Res Vol 49 December 2020, 102081人
2020PBMCGong, P. et al. (2020) Generation of a human iPSC line from an epileptic encephalopathy patient with electrical status epilepticus during sleep carrying KCNA2 (p.P405L) mutation. Stem Cell Res Vol 49 December 2020, 102080人
2020FibroblastVölkner, C. et al. (2020) Generation of an iPSC line (AKOSi006-A) from 成纤维细胞 of an NPC1 patient, carrying the homozygous mutation p.I1061T (c.3182 T > C) and a control iPSC line (AKOSi007-A) using a non-integrating Sendai virus system. Stem Cell Res Vol 49 December 2020, 102056人
2020PBMCBing, S. et al. (2020) Generation of induced pluripotent stem cell GZHMCi002-A from peripheral blood mononuclear cells with APOB mutation. Stem Cell Res Vol 49 December 2020, 102054人
2020PBMCZhu, S. et al. (2020) Generation of genomic-integration-free human induced pluripotent stem cells and the derived cardiomyocytes of X-linked dilated cardiomyopathy from DMD gene mutation. Stem Cell Res Vol 49 December 2020, 102040人
2020PBMCMathieu, F. et al. (2020) Generation of the induced pluripotent stem cell line UHOMi002-A from peripheral blood mononuclear cells of a healthy male donor. Stem Cell Res Vol 49 December 2020, 102037人
2020CellsSteeg, R. et al. (2020) The EBiSC iPSC bank for disease studies. Stem Cell Res Vol 49 December 2020, 102034人
2020PBMCLin, H.-Y., et al. (2020) Reprogramming of a human induced pluripotent stem cell (iPSC) line from a patient with neurodegeneration with brain iron accumulation (NBIA) harboring a novel frameshift mutation in C19orf12 gene. Stem Cell Res Vol 49 December 2020, 102032人
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2020CD34+ bone marrow cellsLee, S.-J. et al. (2020) Generation of normal induced pluripotent stem cell line KUMCi002-A from bone marrow CD34+ cells of patient with multiple myeloma disease having 13q deletion and IGH translocation. Stem Cell Res Vol 49 December 2020, 102030人
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2020FibroblastLuo, F. et al. (2020) Developmental deficits and early signs of neurodegeneration revealed by PD patient derived dopamine neurons. Stem Cell Res Vol 49 December 2020, 102027人
2020Renal Epithelial CellsSu, J. et al. (2020) Generation of five induced pluripotent stem cell lines with DMD/c.497G > T mutation from renal epithelial cells of a Duchenne muscular dystrophy patient and a recessive carrier parent. Stem Cell Res Vol 49 December 2020, 102021人
2020PBMCBozaoglu, K. et al. (2020) Generation of four iPSC lines from Neurofibromatosis Type 1 patients. Stem Cell Res Vol 49 December 2020, 102013人
2020FibroblastXiu, X. et al. (2020) Four induced pluripotent stem cell lines (TRNDi021-C, TRNDi023-D, TRNDi024-D and TRNDi025-A) generated from 成纤维细胞 of four healthy individuals. Stem Cell Res Vol 49 December 2020, 102011人
2020FibroblastAli, E. et al. (2020) Generation of induced pluripotent stem cell (iPSC) lines from a Joubert syndrome patient with compound heterozygous mutations in C5orf42 gene. Stem Cell Res Vol 49 December 2020, 102007人
2020Bone marrow-derived mesenchymal stem cells; Adipose tissue-derived mesenchymal stem cells; Wharton’s Jelly-derived mesenchymal stem cellsAbabneh, N.A et al. (2020) Derivation of three human induced pluripotent stem cell lines (JUCTCi014-A, JUCTCi015-A, JUCTCi016-A) from mesenchymal stem cells (MSCs) derived from bone marrow, adipose tissue and Wharton’s jelly samples. Stem Cell Res Vol 49 December 2020, 102000人
2020FibroblastGe, N. et al. (2020) Generation and characterization of an induced pluripotent stem cell (iPSC) line (NUIGi003-A) from a long QT syndrome type 2 (LQT2) patient harbouring the KCNH2 c.2464G>A pathogenic variant. Stem Cell Res Vol 49 December 2020, 101997人
2020FibroblastGe, N. et al. (2020) Generation and characterization of two induced pluripotent stem cell lines (NUIGi038-A, NUIGi038-B) from dermal 成纤维细胞 of a healthy individual. Stem Cell Res Vol 49 December 2020, 101996人
2020PBMCDatta, I. et al. (2020) Generation of induced pluripotent stem cells (NIMHi002-A and NIMHi003-A) from two sporadic Parkinson's disease patient of East Indian ethnicity. Stem Cell Res Vol 49 December 2020, 101995人
2020PBMCZhu, X. et al. (2020) Generation of induced pluripotent stem cells (NJDTHi001-A) from a Danon disease child with mutation of c.467 T > G in LAMP2 gene. Stem Cell Res Vol 49 December 2020, 101994人
2020FibroblastRatti, A. et al. (2020) Chronic stress induces formation of stress granules and pathological TDP-43 aggregates in human ALS 成纤维细胞 and iPSC-motoneurons. Neurobiology of Disease Vol 145 November 2020, 105051人
2020FibroblastUcuncu, E.,  et al. (2020)  MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia. Nat Commun 11, 6087 (2020)人
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2020Epidermal KeratinocytesChang, YH. et al. (2020) Induced Pluripotent Stem Cell-Differentiated Chondrocytes Repair Cartilage Defect in a Rabbit Osteoarthritis Model. Stem Cell International, 10 November 2020人
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2020Myoblasts & PBMCMetzler, E. et al. (2020) Generation of two human induced pluripotent stem cell lines derived from myoblasts (MDCi014-A) and from peripheral blood mononuclear cells (MDCi014-B) from the same donor. Stem Cell Res Vol 48 October 2020, 101998人
2020PBMCVaidyanath, A. et al. (2020) Establishment of integration free iPSC clones, NCCSi011-A and NCCSi011-B from a liver cirrhosis patient of Indian origin with hepatic encephalopathy. Stem Cell Res Vol 48 October 2020, 101992人
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2020CD34+ cells (from PBMC)Sahabian, A. et al. (2020) Generation of two hiPSC clones (MHHi019-A, MHHi019-B) from a primary ciliary dyskinesia patient carrying a homozygous deletion in the NME5 gene (c.415delA (p.Ile139Tyrfs*8)). Stem Cell Res Vol 48 October 2020, 101988人
2020Myoblasts & PBMCMetzler, E. et al. (2020) Generation of three age and gender matched pairs of human induced pluripotent stem cells derived from myoblasts (MDCi011-A, MDCi012-A, MDCi013-A) and from peripheral blood mononuclear cells (MDCi011-B, MDCi012-B, MDCi013-B) from the same donor. Stem Cell Res Vol 48 October 2020, 101987人
2020FibroblastRolova, T. et al. (2020) Generation of a human induced pluripotent stem cell line (UEFi003-A) carrying heterozygous A673T variant in amyloid precursor protein associated with a reduced risk of Alzheimer’s disease. Stem Cell Res Vol 48 October 2020, 101968人
2020FibroblastAbabneh, N.A et al. (2020) Establishment of a human induced pluripotent stem cell line, JUCTCi012-A, from multiple symmetric lipomatosis (MSL) patient carrying a homozygous Arg707Trp (c.2119C > T) mutation in the MFN2 gene. Stem Cell Res Vol 48 October 2020, 101967人
2020PBMCLiu, S. et al. (2020) Establishment of an induced pluripotent stem cell line (ZZUSAHi002-A) derived from peripheral blood mononuclear cells of a healthy individual. Stem Cell Res Vol 48 October 2020, 101966人
2020FibroblastZhou, D. et al. (2020) Generation of an induced pluripotent stem cell line from the dermal 成纤维细胞 of a patient with arrhythmogenic right ventricular cardiomyopathy carrying a PKP2/c.2489 + 1G > A mutation. Stem Cell Res Vol 48 October 2020, 101965人
2020PBMCSequiera, G.L et al. (2020) Induced pluripotent stem cell line UOMi002-A from a patient with Leigh syndrome with compound heterozygous mutations in the NDUFV1 gene. Stem Cell Res Vol 48 October 2020, 101964人
2020PBMCQuelennec, E. et al. (2020) Generation of two induced pluripotent stem cell lines IMAGINi004-A and IMAGINi005-A from healthy donors. Stem Cell Res Vol 48 October 2020, 101959人
2020成纤维细胞Ratnavadivel, S. et al. (2020) Human pluripotent stem cell line (HDZi001-A) derived from a patient carrying the ARVC-5 associated mutation TMEM43-p.S358L. Stem Cell Res Vol 48 October 2020, 101957人
2020FibroblastWang, W. et al. (2020) Generation of a human induced pluripotent stem cell line PUMCi001-A from a patient with Krabbe disease. Stem Cell Res Vol 48 October 2020, 101937人
2020PBMCBanal, C. et al. (2020) Generation of an iPSC line (IMAGINi022-A) from a patient carrying a SOX10 missense mutation and presenting with deafness, depigmentation and progressive neurological impairment. Stem Cell Res Vol 48 October 2020, 101936人
2020PBMCSequiera, G.L et al. (2020) Establishment of variant free-iPSC (UOMi003-A) line from patient with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes. Stem Cell Res Vol 48 October 2020, 101935人
2020PBMCSequiera, G.L et al. (2020) Generation of human induced pluripotent stem cell (hiPSC) line UOMi001-A from a patient with Leigh-like syndrome harbouring compound heterozygous variants in ECHS1 gene. Stem Cell Res Vol 48 October 2020, 101934人
2020FibroblastKondrateva, E. et al. (2020) Generation of induced pluripotent stem cell line (RCMGi001-A) from human skin 成纤维细胞 of a cystic fibrosis patient with p.F508del mutation. Stem Cell Res Vol 48 October 2020, 101933人
2020Umbilical cord bloodLu, JZ. et al. (2020) An induced pluripotent stem cell line (EHTJUi002-A) derived from a neonate with c.678G>A mutation in the gene FZD4 causing exudative vitreoretinopathy. Stem Cell Res Vol 48 October 2020, 101932人
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2020FibroblastRamos-Gonzalez, P. et al. (2020) Astrocytic atrophy as a pathological feature of Parkinson’s disease with LRRK2 mutation. Research Square人
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2020FibroblastOh, KJ. et al. (2020) Derivation of induced pluripotent stem cell lines from New Zealand donors, Journal of the Royal Society of New Zealand 18 October 2020人
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2020FibroblastUrresti, J. et al. (2020) Cortical Organoids Model Early Brain Development Disrupted by 16p11.2 Copy Number Variants in Autism. bioRxiv, 6 October 2020人
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2020FibroblastKohama, Y. et al. (2020) Adeno-associated virus-mediated gene delivery promotes S-phase entry-independent precise targeted integration in cardiomyocytes. Sci Rep 10, 15348 (2020人
2020FibroblastCowan, C.S. et al. (2020) Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution. Volume 182, Issue 6, 17 September 2020, Pages 1623-1640.e34人
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2020FibroblastAbabneh, N.A et al (2020) Generation of a human induced pluripotent stem cell (iPSC) line (JUCTCi011-A) from skin 成纤维细胞 of a healthy Jordanian male subject. Stem Cell Res Vol 48 October 2020, 101923人
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2020PBMCChen X, et al (2020) An iPSC line (TYWHSTi002-A) derived from a patient with Pendred syndrome caused by compound heterozygous mutations in the SLC26A4 gene. Stem Cell Res Vol 47 August 2020, 101919人
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2020PBMCNiu S, et al (2020) Generation of patient-specific induced pluripotent stem cells (ZZUSAHi001-A) derived from a familial atrial fibrillation patient carrying KCNA5 c.775G>A mutation. Stem Cell Res Vol 47, August 2020, 101915人
2020CD 34+Lee SJ, et al (2020) Generation of an induced pluripotent stem cell line KUMCi001-A from CD34+ bone marrow cells of a patient with acute lymphoblastic leukemia using human placenta-derived cell conditioned medium. Stem Cell Res Vol 47 August 2020, 101913人
2020PBMCZhang Y, et al (2020) Generation of two induced pluripotent stem cell lines (XACHi0010-A, XACHi0011-A) from a Chinese family with combined oxidative phosphorylation deficiency carrying homozygous and heterozygous C1QBP-L275F mutation. Stem Cell Res Vol 47 August 2020, 101912人
2020CD4+ T-cellsVaidyanath A, et al (2020) Development and characterization of two independent integration free iPSC clones NCCSi010-A and NCCSi010-B from a patient with alcoholic liver cirrhosis of Indian ethnicity. Stem Cell Res Vol 47 August 2020, 101911人
2020PBMCFukunaga I, et al (2020) Generation of two induced pluripotent stem cell lines from PBMCs of siblings carrying c.235delC mutation in the GJB2 gene associated with sensorineural hearing loss. Stem Cell Res Vol August 2020, 101910人
2020FibroblastAbabneh, N.A. et al. (2020) Establishment of (JUCTCi007-A) iPSC line from a patient with congenital myasthenic syndrome (CMS) carrying a homozygous mutation p.Arg331Trp (c.991C > T) in the CHRNE gene. Stem Cell Res Vol 47 August 2020, 101906人
2020PBMCYan, Y. et al. (2020) Generation of a human iPSC line CIBi007-A from a patient with young-onset Parkinson’s disease carrying variants in PRKN and HTRA2. Stem Cell Vol Vol 47 August 2020, 101905人
2020PBMCRebs, S. et al. (2020) Generation of pluripotent stem cell lines and CRISPR/Cas9 modified isogenic controls from a patient with dilated cardiomyopathy harboring a RBM20 p.R634W mutation. Stem Cell Res Vol 47 August 2020, 101901人
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2020PBMCPerepelina, K et al (2020) Generation of two iPSC lines (FAMRCi007-A and FAMRCi007-B) from patient with Emery–Dreifuss muscular dystrophy and heart rhythm abnormalities carrying genetic variant LMNA p.Arg249Gln. Stem Cell Res Vol 47 August 2020, 101895人
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2020CellsWarre-Cornish, K. et al. (2020) Interferon-γ signaling in human iPSC–derived neurons recapitulates neurodevelopmental disorder phenotypes. Sci. Adv. 2020; 6 : eaay9506 19 August 2020人
2020FibroblastMazzara, PG. et al. (2020) Frataxin gene editing rescues Friedreich’s ataxia pathology in dorsal root ganglia organoid-derived sensory neurons. Nat Commun 11, 4178 (2020)人
2020FibroblastRichard P. et al. (2020) SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation, Autophagy, 7 August 2020人
2020FibroblastHo, MF. et al (2020) TSPAN5 influences serotonin and kynurenine: pharmacogenomic mechanisms related to alcohol use disorder and acamprosate treatment response. Mol Psychiatry (2020)人
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2020FibroblastSalikhova, D. et al. (2020) Secretome-Mediated Neuroprotective Effects of the hiPSC-derived Glial and Neuronal Progenitor Cells in the Hypoxia-Induced Neuronal Damage (Comparative Study). Research Square人
2020DPSC (Dental Pulp Stem Cells)Bosch, B. et al. (2020) A new alternative for corneal endothelial regeneration using autologous dental pulp stem cells. Research Square 人
2020Fibroblast, PBMCOlivia Krefft, 30 September 2020: Unraveling the pathology of different disease severities in human cerebral organoid models of LIS1-lissencephaly. Dissertation人
2020FibroblastSimon Alexander Sumer, 29. September 2020: Deciphering the role of SHOX2 in atrial fibrillation and sinus node dysfunction. Dissertation人
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2020Fibroblast, PBMCSerra-Vinardell, J. et al (2020) Generation and characterization of four Chediak-Higashi Syndrome (CHS) induced pluripotent stem cell (iPSC) lines. Stem Cell Res Vol 47 August 2020, 101883人
2020FibroblastLi, X. et al. (2020) An integration-free iPSC line ZZUNEUi008-A derived from dermal 成纤维细胞 of a child with cardiac valvular dysplasia carrying a mutation in FLNA gene. Stem Cell Res Vol 47 August 2020, 101882人
2020Wharton’s jelly stem cells of the umbilical cordKong, CM et al (2020) Tissues derived from reprogrammed Wharton’s jelly stem cells of the umbilical cord as a platform to study gestational diabetes mellitus. Stem Cell Res Vol 47 August 2020, 101880人
2020PMBCCai, Y et al (2020) Generation of a human induced pluripotent stem cell line (SHUPLi001-A) from PBMCs of a healthy male donor. Stem Cell Res Vol 47 August 2020, 101871人
2020FibroblastBenabdallah, B., et al. (2020) Myogenic progenitor cells derived from human induced pluripotent stem cell are immune-tolerated in humanized mice. STEM CELLS Transl Med. 2020;1–11人
2020PBMCMenara, G. et al (2020) Generation of an induced pluripotent stem cell (iPSC) line (IMAGINi007) from a patient with steroid-resistant nephrotic syndrome carrying the homozygous p.R138Q mutation in the podocin-encoding NPHS2 gene. Stem Cell Res Vol 46 July 2020, 101878人
2020PBMCNa, DH et al (2020) Generation of a human induced pluripotent stem cell line (CMCi001-A) from a patient with karyomegalic interstitial nephritis with homozygous frameshift deletion mutation c.1985_1994del10 of the FANCD2/FANCI-Associated Nuclease 1 gene. Stem Cell Res Vol 46 July 2020, 101876人
2020PBMCZhang, S.-J. et al (2020) Derivation of an induced pluripotent stem cell line (PUMCHi003-A) from a patient with pulmonary arterial hypertension carrying heterozygous mutation in PTGIS gene. Stem Cell Res Vol 46 July 2020, 101875人
2020Renal epithelial cellsWang, J. et al (2020) Generation of ZJUi003-A, an induced pluripotent stem cell line from a Wilson’s disease patient carrying a c.180_181del mutation in ATP7B gene. Stem Cell Res Vol 46 July 2020, 101873人
2020PBMCWang, A. et al (2020) Generation of an induced pluripotent stem cell line (SHCDNi003-A) from a one-year-old Chinese Han infant with Allan–Herndon–Dudley syndrome. Stem Cell Res Vol 46 July 2020, 101872人
2020PBMCChen, J. et al. (2020) Generation of human induced pluripotent stem cell (SKLRMi001-A) from a patient with partial androgen insensitivity syndrome (PAIS). Stem Cell Res Vol 46 July 2020, 101863人
2020成纤维细胞Janz, A. et al. (2020) Generation of two patient-derived iPSC lines from siblings (LIBUCi001-A and LIBUCi002-A) and a genetically modified iPSC line (JMUi001-A-1) to mimic dilated cardiomyopathy with ataxia (DCMA) caused by a homozygous DNAJC19 mutation. Stem Cell Res 46 July 2020, 101856人
2020FibroblastBuers, I. et al. (2020) Crisponi syndrome/cold-induced sweating syndrome type 2: Reprogramming of CS/CISS2 individual derived 成纤维细胞 into three clones of one iPSC line. Stem Cell Res Vol 46 July 2020, 101855 
2020FibroblastArbini, A et al. (2020) Generation of three induced pluripotent stem cell (iPSC) lines from a patient with developmental epileptic encephalopathy due to the pathogenic KCNA2 variant c.869T>G; p.Leu290Arg (NUIGi052-A, NUIGi052-B, NUIGi052-C). Stem Cell Res Vol 46 July 2020, 101853人
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2020Type 1 Diabetes cellsLeite NC, et al (2020) Modeling Type 1 Diabetes In Vitro using Human Pluripotent Stem Cells. Cell Reports 32, 107894, July 14 2020人
2020FibroblastWalsh, P. et al. (2020) Accelerated differentiation of human pluripotent stem cells into neural lineages via an early intermediate ectoderm population. Stem Cells Vol 38:1400–1408人
2020PBMCKim, KY et al (2020) Downregulated miR-18b-5p triggers apoptosis by inhibition of calcium signaling and neuronal cell differentiation in transgenic SOD1 (G93A) mice and SOD1 (G17S and G86S) ALS patients. Transl Neurodegener 9, 23 (2020).人
2020FibroblastGrønning Hansen, M et al (2020) Grafted human pluripotent stem cell-derived cortical neurons integrate into adult human cortical neural circuitry. STEM CELLS Transl Med. 2020;9:1365–1377.人
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2020PBMCChristidi, E. et al (2020). Variation in RARG increases susceptibility to doxorubicin-induced cardiotoxicity in patient specific induced pluripotent stem cell-derived cardiomyocytes. Sci Rep 10, 10363 (2020)人
2020PBMCSubramani, P et al (2020). Plasmodium vivax liver stage assay platforms using Indian clinical isolates. Malar J 19, 214 (2020).人
2020成纤维细胞Das Sharma, S. et al. (2020) Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns. Molecular Autism 11, 52 (2020)人
2020Liver cells (hepatic non-parenchymal)Kirchner VA, et al (2020) Reprogramming of Human Hepatic Non‐Parenchymal Cells: Step‐by‐Step Protocol. Current Protocols in Stem Cell Biology 17 June 2020人
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2020CD34+ cellsDrick N, et al (2020) Generation of two human induced pluripotent stem cell lines (MHHi017-A, MHHi017-B) from a patient with primary ciliary dyskinesia carrying a homozygous mutation (c.7915C > T [p.Arg2639*]) in the DNAH5 gene. Stem Cell Res Vol 46 July 2020, 101848. Doi.org/10.1016/j.scr.2020.101848人
2020CD34+ cellsDahlmann, J et (2020) Generation of two hiPSC lines (MHHi016-A, MHHi016-B) from a primary ciliary dyskinesia patient carrying a homozygous 5 bp duplication (c.248_252dup (p.Gly85Cysfs*11)) in exon 1 of the CCNO gene. Stem Cell Res Vol 46 July 2020, 101850. Roi.org/10.1016/j.scr.2020.101850人
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2020FibroblastSun C, et al (2020) Duchenne muscular dystrophy hiPSC-derived myoblast drug screen identifies 3 compounds that ameliorate disease in mdx mice人
2020Primary LymphocytesFantuzzo, JA et al (2020) Development of a high-throughput arrayed neural circuitry platform using human induced neurons for drug screening applications. Lab on a chip, Issue 6, 2020人
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2020FibroblastShen X, et al (2020) Progress towards drug discovery for Friedreich’s Ataxia: Identifying synthetic oligonucleotides that more potently activate expression of human frataxin protein. Bioorganic and Medicinal Chemistry Vol 28 Issue 11, 1 June 2020, 115472. Doi.org/10.1016/j.bmc.2020.115472人
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2019Retinal pigment epithelial cellsHuang CY, et al (2019) Human iPSC banking: barriers and opportunities. Journal of Biomedical Science 26:87. Doi.org/10.1186/s2929-019-578-x人
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2019Dendritic cells (DC)Horton C, et al (2019) iPS cells reprogrammed from primary dendritic cells provide an abundant source of immunostimulatory dendritic cells for use in immunotherapy. Stem Cells Journals October 17, 2019. Doi.org/10.1002/stem.3095Mouse
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2019Antigen-specific T-cellsNishimura T, et al (2019) Human iPSC Generation from Antigen-Specific T Cells. In Vitro Differentiation of T-cells pp 53-57, August 9, 2019人
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2019FibroblastCarrio M, et al (2019) Reprogramming Captures the Genetic and Tumorigenic Properties of Neurofibromatosis Type 1 Plexiform Neurofibromas. Stem Cell Reports Vol 11, 411-426, February 12, 2019, doi.org/10.2016/jstemcr2019.01.001人
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2018PBMCHennig AF, et (2018) Generation of a human induced pluripotent stem cell line (BIHi002-A) from a patient with CLCN7-related infantile malignant autosomal recessive osteopetrosis. Stem Cell Res Dec. 26, 101367; doi.org/10.1016/j.scr.2018.101367人
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2018PBMCZhang QJ, et al (2018) Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis Nature Communications 9, 5230, Dec. 7, 2018人
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2018PBMCEckford PDW, et al. (2018) The CF Canada-Sick Kids Program in individual CF therapy: A resource for the advancement of personalized medicine in CF JCF 2018; March 31; JCF-01643; doi.org/10.1016/j.jcf.2018.03.013人
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2018Urine cellsSan H, et al (2018) Generation of induced pluripotent stem cell line (ZZUi011-A) from urine sample of a normal human. Stem Cell Res 2018; March 09; 29:28-31; doi.org/10.1016/j.scr.2018.03.002人
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2018CD34+ cellsYe L, et al. (1018) MiR-126 enhances VEGF expression in induced pluripotent stem cell-derived retinal neural stem cells by targeting spred-1. Int J Clin Exp Pathol 2018; Feb 01; 11(2):1023-1030.人
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2018Keratinocytes/HairSulkowski M, et (2018) Introduction of Exogenous HSV-TK Suicide Gene Increases Safety of Keratinocyte-Derived Induced Pluripotent Stem Cells by Providing Genetic "Emergency Exit" Switch. Int J Mol Sci 2018 Jan 9;19(1). pii: E197. doi: 10.3390/ijms19010197.人
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2017Dental mesenchymal stem cells (SCAP, DPSCs)Tan X, et al. (2017) Efficient generation of transgene- and feeder-free induced pluripotent stem cells from human dental mesenchymal stem cells and their chemically defined differentiation into cardiomyocytes. Biochem Biophys Res Comm. In press 05 Dec 17. 人
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2017Stem cells from apical papilla (SCAP) and dental pulp stem cells (DPSC)Tan X, et al. (2017) Characterization of microRNAs expression profiles in human dental-derived pluripotent stem cells. PLoS One 2017 May 18;12(5):e0177832. doi: 10.1371/journal.pone.0177832. eCollection 2017.人
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2017PBMCsWarren CR, 等（2017）诱导多能干细胞分化使代谢性疾病中 GWAS 变异的功能验证成为可能。PubMed人
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2014Frozen non-cryoprotected dural and scalp 成纤维细胞Sproul AA et al. (2014) Generation of iPSC lines from archived non-cryoprotected biobanked dura mater. Acta Neuropathol Commun 2:4 doi:10.1186/2051–5960-2-4.人
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2013PBMCChen IP 等人（2013）通过整合无关的仙台病毒载体对颅干骺发育不良患者外周血中的诱导多能干细胞进行重编程。PubMed人
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