Chromatography and Mass Spectrometry Instruments for Clinical Research and Toxicology Applications

Thermo Fisher Scientific is committed to providing innovative solutions to help meet the demanding needs of clinical, forensic and translational research. We are your partner to help accelerate your path toward developing and applying differentiated clinical applications today and in the future.

The purpose of this page is to connect scientists (whether new or experienced) to our clinical research and toxicology LC-MS Application solutions. Along with our innovative solutions to difficult research challenges, we partner with scientists to bring you the most current approaches and thinking in this field.

Speak to specialist Join our community

To narrow your search; type a category, keyword, analyte or instrument in the Search box and click Search. To display all resources, clear the Search box and click Search.

No records were found matching your criteria

Category	Title	Analyte	Instrument
Clinical research	Streamlined workflow for absolute quantitation of therapeutic monoclonal antibodies using Promise Proteomics mAbXmise kits and a TSQ Altis Plus mass spectrometer	Monoclonal Antibodies	Triple Quadrupole
Clinical research	Quantification of Antiepileptics in Human Plasma or Serum by LC-HRAM(MS) for Clinical Research	Antiepileptics	HRAM MS
Clinical research	Quantification of Tricyclic Antidepressants in Human Plasma or Serum by Liquid Chromatography-Tandem Mass Spectrometry for Clinical Research	Antidepressants	Triple Quadrupole
Clinical research	Quantification of Antiepileptics in Human Plasma or Serum by Liquid Chromatography-Tandem Mass Spectrometry for Clinical Research	Antiepileptics	Triple Quadrupole
Clinical research	Quantification of Antidepressants in Human Plasma or Serum by Liquid Chromatography-Tandem Mass Spectrometry for Clinical Research	Antidepressants	Triple Quadrupole
Clinical research	Quantification of Antimycotics in Human Plasma or Serum by Liquid Chromatography-Tandem Mass Spectrometry for Clinical Research	Antimycotics	Triple Quadrupole
Clinical research	Quantification of Mycophenolic Acid in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry for Clinical Research	Mycophenolic Acid	Triple Quadrupole
Clinical research	Quantification of Thirty-One Antidepressants in Human Serum by Turboflow Chromatography Coupled to High-Resolution Orbitrap Mass Spectrometry for Clinical Research	Antidepressants	HRAM MS
Clinical research	Analytical Evaluation for the Quantitation of Fifteen Antibiotics in Plasma by Liquid Chromatography Coupled to High-Resolution, Accurate-Mass Measurements for Clinical Research	Antibiotics	HRAM MS
Clinical research	Quantitative Analysis of Antifungal Drugs using PaperSpray Tandem Mass for Clinical Research	Antifungals	Triple Quadrupole / Paper Spray
Clinical research	Quantification of nine antimycotic drugs in human plasma or serum by LC-HRAM(MS) for clinical research	Antimycotics	HRAM MS
Clinical research	Robust, Reproducible, and Easy-to-Implement Plasma Protein Profiling Workflow using High-Flow UHPLC/MS/MS Without Depletion	Plasma Proteome	HRAM MS
Clinical research	Quantification of Mycophenolic Acid in Human Plasma by LC-HRAM Mass Spectrometry for Clinical Research	Mycophenolic Acid	HRAM MS
Clinical research	Quantification of 25-Hydroxyvitamin D2 and D3 in Human Plasma by LC-HRAM-MS for Clinical Research	Vitamin D	HRAM MS
Clinical research	Quantification of 15 Tricyclic Antidepressants in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry for Clinical Research	Antidepressants	Triple Quadrupole
Clinical research	Quantification of Eight Antimycotics in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry for Clinical Research	Antimycotics	Triple Quadrupole
Toxicology	Selective and sensitive measurement of 17 steroids in human serum using a Stellar mass spectrometer	Steroids	Triple Quadrupole
Toxicology	Simultaneous quantitation of 77 therapeutic and clinical toxicology drugs in dried blood spots using the fully automated Transcend DSX-1 system	Therapeutic, Drugs of Abuse	HRAM MS
Toxicology	Detection of Controlled Substances in Blood Samples using the Verispray Ion Source with TSQ Altis MS for Clinical Research and Forensic Toxicology	Drugs of Abuse	Triple Quadrupole / Verispray
Toxicology	Quantification of 78 Drugs of Abuse in Human Blood by Liquid chromatography – HRAM Orbitrap Mass Spectrometry for Clinical Research	Drugs of Abuse	HRAM MS
Toxicology	Improving Limit of Quantification in Clinical Research by Combining Paperspray with FAIMS Technology	Amitriptyline	Triple Quadrupole
Toxicology	Quantification of Benzodiazepines in Human Plasma or Serum by Liquid Chromatography Tandem Mass Spectrometry for Clinical Research	Benzodiazepines	Triple Quadrupole
Toxicology	Tomorrow’s Quantitation with LC-MS/MS: Fast Screening and Quantitation of Drugs of Abuse in Urine for Forensic Toxicology	Drugs of Abuse	Triple Quadrupole
Toxicology	Forensic Toxicology Quantitation of 30 Benzodiazepines in Whole Blood using a High-Resolution, Accurate-Mass (HRAM) Mass Spectrometer	Benzodiazepines	HRAM MS
Toxicology	Determination of Cannabinoids in Low-Volume Human Whole Blood Samples by Online Extraction using Turbulent Flow Chromatography and HRAM Orbitrap MS	Cannabinoids	HRAM MS
Toxicology	Targeted Forensic Screening and Semi-Quantitation of Drugs in Plasma using High-Resolution, Accurate Mass Detection and Online Sample Preparation	Drugs of Abuse	HRAM MS
Toxicology	Quantification of 36 benzodiazepines in human plasma or serum by LC-HRAM(MS) for clinical research	Benzodiazepines	HRAM MS
Toxicology	Quantification of methylmalonic acid in human plasma or serum for use in clinical research	Methylmalonic acid	Triple Quadrupole
Toxicology	Quantification of Ethyl Glucuronide and Ethyl Sulfate in Human Urine by LC-HRAM(MS) for Clinical Research	EtG, EtS	HRAM MS
Toxicology	Quantification of Phosphatidylethanol (PEth) 16:0/18:1 in Whole Blood with High-Resolution Accurate Mass Spectrometry for Clinical Research	Peth	HRAM MS
Toxicology	Quantitation of 22 fentanyl analog compounds on an Orbitrap Exploris 120 mass spectrometer	Fentanyls	HRAM MS
Toxicology	Screening and Semi-Quantitation of 212 Fentanyl Analog Compounds by the Orbitrap Exploris 120 Mass Spectrometer	Fentanyl	HRAM MS
Toxicology	Quantification of Eight Antimycotics in Human Plasma by LC-HRAM-MS for Clinical Research	Antimycotics	HRAM MS
Toxicology	Quantification of 34 Benzodiazepines in Human Plasma by LC-HRAM-MS for Clinical Research	Benzodiazepines	HRAM MS
Toxicology	Quantitation of an oral fluid drug panel including THC using the new Stellar mass spectrometer	Drugs of Abuse	Triple Quadrupole
Biomarkers	Fast and accurate quantitation of intact IGF-1 from serum by HRAM LC-MS for clinical research	IGF-1	HRAM MS
Biomarkers	Quantification of Insulin-Like Growth Factor 1 in Human Serum by Vanquish UHPLC with Q Exactive High-Resolution Accurate-Mass Mass Spectrometry for Clinical Research	IGF-1	HRAM MS
Endocrinology	Quantification of 25-Hydroxyvitamin D2 and D3 in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry for Clinical Research	Vitamin D	Triple Quadrupole
Endocrinology	Confident Quantitation of 25-Hydroxyvitamin D2 and D3 in Human Plasma for Clinical Research by Liquid Chromatography-Tandem Mass Spectrometry with Simple, Robust Sample Preparation	Vitamin D	Triple Quadrupole
Endocrinology	Achieving High Sensitivity and Robustness – Analysis of Estrone and Estradiol in Human Serum by Tsq Altis Mass Spectrometer for Clinical Research	Estrone/Estradiol	Triple Quadrupole
Endocrinology	Quantification of 25-Hydroxyvitamin D2 and D3 in Human Plasma by Liquid Chromatography Coupled to High-Resolution Orbitrap Mass Spectrometry for Clinical Research	Vitamin D	Triple Quadrupole
Endocrinology	Quantitation of 25-OH Vit D in human plasma and serum for clinical research by LC-MS/MS	Vitamin D	Triple Quadrupole
Endocrinology	Confident Quantification of Steroids: Analysis in Human Plasma or Serum by Liquid Chromatography Tandem Mass Spectrometry for Clinical Research	Steroids	Triple Quadrupole
Endocrinology	Quantitative Analysis of Estradiol and Testosterone in Plasma for Clinical Research using the TSQ Altis Triple Quadrupole Mass Spectrometer	Estradiol/Testosterone	Triple Quadrupole
Endocrinology	Cortisol and cortisone in human urine by LC-MS: Quantification by high-resolution Orbitrap mass spectrometry	Cortisol/Cortisone	HRAM MS
Endocrinology	Quantification of six steroids in human serum by TurboFlow chromatography coupled to tandem mass spectrometry	Steroids	Triple Quadrupole
Endocrinology	Blood serum rT3 quantitation by LC-MS/MS: Using liquid-liquid extraction following protein precipitation for research	rT3	Triple Quadrupole
Endocrinology	Quantification of vitamins B1, B2, and B6 in human blood by liquid chromatography-tandem mass spectrometry for clinical research	Vitamin B	Triple Quadrupole
Therapeutic drug monitoring	Combined Paperspray and FAIMS Technology for Rapid Quantification of Immunosuppressants in Whole Blood for Clinical Research	Immunosuppressants	Triple Quadrupole / Verispray / FAIMS
Therapeutic drug monitoring	Tomorrow’s Quantitation: Increased Robustness for Quantitation of Immunosuppressant Drugs in Blood with the TSQ Fortis MS for Clinical Research	Immunosuppressants	Triple Quadrupole
Therapeutic drug monitoring	Quantification of Immunosuppressants in Human Blood by Liquid Chromatography-Tandem Mass Spectrometry for Clinical Research	Immunosuppressants	Triple Quadrupole
Therapeutic drug monitoring	Testing Robustness: Immunosuppressant Drugs in Blood with a TSQ Quantis MS for Clinical Research	Immunosuppressants	Triple Quadrupole
Therapeutic drug monitoring	Confident quantification of immunosuppressants in human whole blood by LC-MS for clinical research	Immunosuppressants	Triple Quadrupole
Therapeutic drug monitoring	Fast and robust quantification of 36 antidepressants in human plasma by LC-HRAM(MS) using the Orbitrap Exploris 120 mass spectrometer for clinical research	Antidepressants	HRAM MS
Therapeutic drug monitoring	Quantification of immunosuppressants in human blood by LC-HRAM mass spectrometry for clinical research	Immunosuppressants	HRAM MS
Disease & disorders	Quantification of free metanephrines in human plasma by LC-MS/MS for clinical research		Triple Quadrupole
Disease & disorders	Quantification of Total Homocysteine in Human Plasma or Serum by Liquid Chromatography-Tandem Mass Spectrometry for use in Clinical Research		Triple Quadrupole
Disease & disorders	Robust, Reliable Assay to Quantify Total Homocysteine in Human Plasma or Serum by Liquid Chromatography Tandem Mass Spectrometry for use in Clinical Research		Triple Quadrupole
Disease & disorders	Determination of inborn errors of metabolism: Quantification of amino acids and acylcarnitines in dried blood spots		Triple Quadrupole
Disease & disorders	Quantification of amino acids and acylcarnitines in dried blood spots by FIA-MS/MS		Triple Quadrupole
Disease & disorders	Comparison of three automated data processing and reporting approaches for inborn errors of metabolism by LC-MS FIA		Triple Quadrupole
Disease & disorders	Simultaneous Analysis of Amino Acids, Acylcarnitines, and Succinylacetone in Dried Blood Spots for Research using Nonderivatized and Derivatized Methods		Triple Quadrupole
Disease & disorders	LC-MS for detection of SARS-CoV-2 viral and host proteins		Triple Quadrupole / HRAM MS
Clinical Research	Quantification of Eight Antimycotics in Human Plasma using an Orbitrap Exploris 120	Antimycotics	HRAM MS
Disease & disorders	Quantification of Free Metanephrines in Human Plasma by LC-HRAM Mass Spectrometry for Clinical Research	Metanephrines	HRAM MS
Disease & disorders	Quantification of Mycophenolic Acid in Human Plasma using an Orbitrap Exploris 120	Mycophenolic acid	HRAM MS
Clinical research	Fast and Robust Quantification of 15 Tricyclic Antidepressants in Human Plasma by LC-HRAM(MS)	Antidepressants	HRAM MS
Clinical research	Quantification of Total Homocysteine in Human Plasma or Serum by LC-HRAM-MS for Clinical Research	Antidepressants	LC-HRAM-MS
Therapeutic drug monitoring	Quantification of 28 Neuroleptics in Human Plasma by LC-HRAM-MS for Clinical Research	Antipsychotics	HRAM MS
Therapeutic drug monitoring	Quantification of Free Metanephrines in Human Plasma by LC-HRAM Mass Spectrometry for Clinical Research	Antipsychotics	HRAM MS
Toxicology	Quantification of 35 Benzodiazepines in Human Plasma by LC-HRAM-MS for Clinical Research	Benzodiazepines Instrument	HRAM MS
Therapeutic Drug Monitoring	Quantification of Four Immunosuppressants in Human Blood by LC-HRAM-MS for Clinical Research	Immunosuppressants	HRAM MS
Therapeutic Drug Monitoring	Quantification of 36 Antidepressants in Human Plasma by LC-HRAM-MS for Clinical Research	Antidepressants Instrument	HRAM MS
Clinical Research	Quantification of 27 Antiepileptics in Human Plasma by LC-HRAM-MS for Clinical Research	Antiepileptics Instrument	HRAM MS
Therapeutic drug monitoring	Quantification of 28 Neuroleptics in Human Plasma by LC-HRAM-MS for Clinical Research	Antipsychotics	HRAM MS
Toxicology	Fully Automated Dried Spot Analysis for the Rapid Quantitation of Tramadol and its Metabolites in Various Matrices	Tramadol	Triple Quadrupole
Clinical Research	Quantitative analysis of 28 trace elements in human plasma and serum by triple quadrupole inductively coupled plasma	Trace Elements	Triple Quadrupole / ICP-MS
Toxicology	Direct quantitation of phosphatidylethanol (PEth) in volume-controlled dried whole blood spots using the fully automated Transcend DSX-1 system	PEth	Triple Quadrupole
Toxicology	HRAM screening, quantitation, and confirmation of drugs with Tox Explorer Orbitrap Exploris platform	Drugs of Abuse	HRAM MS
Toxicology	All-in-one LC-MS/MS toxicology solution for drugs of abuse quantitation using the TSQ Quantis Plus mass spectrometer	Drugs of Abuse	Triple quadrupole
Toxicology	Quantitative analysis of cannabinoids in urine and oral fluid using reactive paper spray tandem mass spectrometry for clinical research and forensic toxicology	Cannabinoids	Triple Quadrupole/Verispray
Clinical Research	Monitoring the intact light chain of therapeutic monoclonal antibodies in human serum using an Orbitrap Exploris 240 mass spectrometer for clinical research	Monoclonal Antibodies	HRAM
Therapeutic drug monitoring	Immunosuppressants in dried blood spots by Transcend DSX-1 system	Immunosuppressants	Triple Quadrupole
Toxicology	Utilizing HRAM Orbitrap mass spectrometry to quantitate 106 drugs of abuse in urine	Drugs of Abuse	HRAM MS
Toxicology	Triple Quadrupole LC-MS/MS method to quantitate 106 drugs of abuse in urine	Drugs of Abuse	Triple Quadrupole
Diseases and Disorders	Quantitation of amino acids and acylcarnitines in DBS by FIA-Orbitrap mass spectrometry for Inborn Errors of Metabolism	Amino acids and acylcarnitines	HRAM MS
Diseases and Disorders	Quantification of amino acids, acylcarnitines, and succinylacetone in DBS by FIA-MS/MS for Inborn Errors of Metabolism	Amino acids, acylcarnitines, and succinylacetone	Triple Quadrupole
Diseases and Disorders	Enhancing detection of hemoglobin variants in clinical research using dried blood spot and high-resolution accurate mass (HRAM) Orbitrap mass spectrometry	Hemoglobinopathies	HRAM MS
Biomarkers	Quantitation of lysosphingolipids in dried blood spots and plasma using high-resolution mass spectrometry for sphingolipidoses	Lysosphingolipids	HRAM MS
Clinical research	Improved specificity for targeted LC-MS/MS measurements of 2,3-dinor-11β-prostaglandin F2α in urine using FAIMS technology	Prostaglandin	Triple Quadrupole / FAIMS
Toxicology	Rapid postmortem analysis of novel psychoactive substancesusing a high-resolution Orbitrap mass spectrometry method	Drugs of Abuse	HRAM MS
Disease & disorders	Measurement of enzyme activities in dried blood spots by targeted high-resolution mass spectrometry for six lysosomal diseases	Sphingolipidoses	HRAM MS
Endocrinology	Quantification of steroids in human serum by TurboFlow online sample cleanup using a Transcend VTLX-1 UHPLC system	Steroids	Triple Quadrupole
Toxicology	Behind the bench: Tips to simultaneously analyze THC, its metabolites, and other drugs of abuse using LC-MS	Drugs of Abuse	Triple Quadrupole
Toxicology	80 drugs of abuse in whole blood with the TSQ Certis Triple Quadrupole MS	Drugs of Abuse	Triple Quadrupole
Biomarkers	Robust peptide quantitation using the TSQ Certis triple quadrupole mass spectrometer	Peptides	Triple Quadrupole
Endocrinology	Robust and sensitive quantification of 18 steroids using human serum with the TSQ Certis mass spectrometer	Steroids	Triple Quadrupole

Application - The product is For General Lab Use Only - Not For Diagnostic Procedures

Our general purpose product lines are not intended for in vitro diagnostic purposes in accordance with our product documentation, manuals, and labels. They are designated for General Laboratory Use Only.

Our general purpose product lines have not been tested or validated for such applications and their use for in vitro diagnostic purposes may result in health and safety risks.

The product is For General Lab Use Only - Not For Diagnostic Procedures. The application is For Research Use Only - Not For Use In Diagnostic Procedures.

Thermo Scientific Orbitrap Exploris 与 Excedion 系列质谱仪为配备大气压电离（API）源的 Orbitrap 仪器，适用于液相色谱（LC）-质谱（MS）的高通量应用。该类仪器设计为置于实验室台面，并能在色谱峰处保持质量准确度（mass accuracy），通过高分辨率、准确质量（high‑resolution accurate‑mass）检测支持可靠的鉴定与定量。