Thermo Scientific Vanquish Duo LC Systems combine individual components of our award-winning Vanquish platform to create unique dual-channel instruments.

The complete Vanquish Duo LC System portfolio contains four individual workflows designed to meet your specific application needs that demand higher productivity or sample knowledge:

  • Dual LC
  • Dual LC-MS
  • Tandem LC or LC-MS
  • Inverse Gradient

Each of the four configurations is built to address a specific analytical challenge and uses a second pump to improve your productivity or quantification capabilities compared to a single-channel instrument.

Your actual productivity gains will depend on the analytical application, detector type and specific Vanquish Duo workflow you choose.

Vanquish Duo UHPLC Systems
for Dual LC

Vanquish Duo UHPLC Systems for Dual LC
Vanquish Duo UHPLC Systems
for Dual LC‑MS

Vanquish Duo UHPLC Systems for Dual LC-MS
Vanquish Duo HPLC and UHPLC Systems for Tandem LC or LC-MS
Vanquish Duo HPLC and UHPLC Systems for Tandem LC or LC-MS
Vanquish Duo HPLC and UHPLC Systems for Inverse Gradient
Vanquish Duo HPLC and UHPLC Systems for Inverse Gradient
System feature
Doubles your throughput with two independent UHPLC channels in one stackDoubles your throughput for LC-MSFeatures offline column regeneration so you can maximize productivity by gaining detector utilizationProvides a uniform response for all detectable analytes with the Charged Aerosol Detection
Analytical benefit
Gain a 100% increase in throughput with a single LC footprintGain up to a 100% increase in throughput with a single MS detectorGain an average of 40% in throughput depending on method conditionsGain semi-quantification of unknowns without needing individual standards
Operating pressure
1000 – 1500 bar1000 – 1500 bar700 – 1500 bar700 – 1500 bar
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Hear how drug discovery scientists accelerate lead selection by maximizing MS detector use with the Vanquish Duo System for Tandem LC-MS.

See how a CDMO uses the Vanquish Duo System for Dual LC to accelerate the time to market and improve ROI.

 

What our customer’s really love
"We are living a love story with Vanquish Duo + CAD. With each method developed sensitivity keeps the flame lit. In addition to sensitivity, its robustness and reliability keep our relationship secure. Coupled with CAD, we go further with this love story that precisely reveals unknown compounds. It is the beginning of a long love story. Research and technology together, streamlining processes, reducing costs with maximum quality...what's not to love?"
Emília M, GM Regulatórios
"My Lab is full of Vanquish Duo systems! The ability to have 2 runs going at the same time for different projects is amazing! Efficient and time savings is priceless! AND, my projects that require 2 different detectors, I can plumb a system to analyze both simultaneously! The ability to customize and add-ons, these systems have a long bright future ahead! Lab life is GREAT!"
Marc I., Patheon
"We like our Vanquish Duo UHPLC system because it doesn’t take up much bench space as we are limited on space for all of the equipment in the lab and it has high throughput capability with the 2 flow paths."
Kathy G., Alkermes
Vanquish Duo UHPLC Systems for Dual LCVanquish Duo UHPLC Systems for Dual LC-MSVanquish Duo HPLC and UHPLC Systems for Tandem LC or LC-MSVanquish Duo HPLC and UHPLC Systems for Inverse Gradient
Benefit
Doubled productivity with 2 UHPLC pumps in one stackIntegrated multi-channel LC for ultra-high-throughput LC-MSMaximized detector utilization by using offline column reconditioningUniform Response with charged aerosol detection
Supported systems
Vanquish Flex
Vanquish Horizon  
Vanquish Flex
Vanquish Horizon  
Vanquish Core
Vanquish Flex
Vanquish Horizon  
Vanquish Core
Vanquish Flex
Vanquish Horizon  
Applicable autosampler
Dual split samplerDual split samplerSplit samplerSplit sampler
Applicable detector(s)
2 detectors1 mass spectrometer1 detector and/or 1 mass spectrometer1 Vanquish Charged Aerosol Detector
Software control
Thermo Scientific Chromeleon CDS Thermo Scientific Standard System Integration for Waters™ Empower™ 3 CDS softwareThermo Scientific Aria MX softwareThermo Scientific Chromeleon CDS Thermo Scientific Standard System Integration for Thermo Scientific XCalibur softwareThermo Scientific Chromeleon CDS Thermo Scientific Standard System Integration for Waters™ Empower™ 3 CDS software
Check out the HPLC resources tool for more information on Vanquish Duo LC Systems.
Style Sheet for Global Design System
CMD Wide-format style fixes