Identifying and depleting genes of interest
One goal, many options
Our effective premium siRNAs are designed to provide superior results for your loss-of-function or cellular pathway studies. All Invitrogen™ Silencer™ and Silencer™ Select siRNA libraries, whether predefined or custom-made, are supplied with full siRNA sequence information and, when available, with siRNA validation data.
Our Human Cancer Genome siRNA Libraries contain gene targets commonly associated with cancers. Often, changes in these genes result in cell pathways that allow cells to divide and survive when they normally would die. Furthermore, mutations that cause loss or reduction in function can result in the progression to cancer, usually in combination with other genetic changes. Our Human Tumor Suppressor siRNA Libraries contain tumor suppressor genes, or anti-oncogenes, which protect cells on the path to cancer. The Human Cancer and Tumor Suppressor siRNA libraries enable researchers to expedite discovery with gene targets and provide superior results for loss of function studies.
The Silencer™ Select Human Cancer Genome siRNA Library contains three unique, non-overlapping siRNAs for each of 532 cancer-associated genes. Silencer Select siRNAs are designed with industry leading design algorithms and include LNA™ modifications to enable efficacy, specificity, and potency, helping to ensure accurate and consistent silencing for RNAi screens in cancer target discovery.
The Silencer™ Human Cancer Genome siRNA Library contains three siRNAs for each of 524 cancer-associated genes. Silencer siRNAs are unmodified but are designed with stringent bioinformatics to avoid off-target effects, allowing accurate and cost-effective RNAi screening in cancer target discovery programs.
The Silencer™ Select Human Tumor Suppressor siRNA Library contains siRNAs targeting 745 tumor suppressor genes. The Silencer Select Human Tumor Suppressor siRNA Library allows highly robust RNAi screening using three unique, non-overlapping siRNAs per gene target. Silencer Select Human Tumor Suppressor siRNAs are designed with our best-in-class design algorithms and include LNA chemical modifications. Thus, this library offers an essential platform for accurate and consistent silencing for studying the role of tumor suppressor genes.
The Silencer™ Human Tumor Suppressor siRNA Library contains unmodified siRNAs targeting 725 tumor suppressor genes. The Silencer Select Human Tumor Suppressor siRNA Library allows highly robust RNAi-based screening using three siRNAs per gene target that are designed using stringent bioinformatic algorithms.