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Invitrogen
Estrogen Receptor alpha (ER alpha) ER Alpha Recombinant Protein
产品信息
A15674
产品规格
种属
Human
Expression System
Insect cells
分子量
66.4 kDa
分类
Recombinant
类型
Protein
纯度
80% as determined by a SDS-PAGE gel stained with SimplyBlue™ SafeStain.
偶联物
形式
Liquid
浓度
See Label
纯化类型
purified
保存液
proprietary buffer
内含物
no preservative
保存条件
-80° C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
产品详细信息
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
ER (Estrogen Receptor) Alpha Recombinant Protein is an insect cell-expressed, full-length, untagged, human nuclear hormone receptor that binds [3H]-estradiol with sub-nM affinity in hydroxylapatite assays and binds specifically to estrogen response element (ERE) sequences.
ER alpha full-length recombinant protein is:
• Flexible-use in your in-house assay or as part of our PolarScreen™ ER Alpha Competitor assays for a complete assay solution
• Ready to use-active, purified, and native (untagged)
• Convenient-available in bulk sizes
ER Alpha Recombinant Protein is manufactured under the strictest quality parameters. This product is guaranteed for 6 months after purchase. Contact us for bulk quantities or for assistance with other nuclear receptor assay needs, from assay development to library screening and beyond.
Used in:
PolarScreen™ ER Alpha Competitor Assay, Red
PolarScreen™ ER Alpha Competitor Assay, Green
Protein Form: Recombinant, Full Length
靶标信息
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp686N23123; ER; ER-alpha; ER36; esr 1; esr-1; Estradiol receptor; estrogen nuclear receptor alpha; Estrogen receptor; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; estrogen receptor alpha splice variant, CTERP-1; estrogen receptor alpha splice variant, ERalphaDup5; estrogen receptor alpha splice variant, ERalphai45a; estrogen receptor alpha splice variant, ERalphai45bL; estrogen receptor alpha splice variant, ERalphai45bS; estrogen receptor alpha splice variant, ERalphai45c; estrogen receptor alpha splice variant, ERalphai56; estrogen receptor alpha splice variant, ERalphai67; hER-alpha36; Nuclear receptor subfamily 3 group A member 1; RP1-130E4.1
基因别名: ER; Era; ESR; ESR1; ESRA; ESTRR; NR3A1
UniProt ID: (Human) Q13511
Entrez Gene ID: (Human) 2099
