This peptide corresponds to 18 amino acids near the center of human ATG16.
PEP-0609 can be used as a blocking peptide with polyclonal antibody PA5-20489.
Autophagy related protein 16 L is encoded by the ATG16L gene and is located on chromosome 2 in humans. It is also known as WD30 or IBD10 (Inflammatory Bowel Disease 10). ATG 12 and ATG5 conjugate with each other and undergoes homo oligomerisation with ATG16L to form an 800 kDa complex called the Atg16L complex. This complex facilitates coupling or lipidation of LC3 to phosphatidylethanolamine (PE) and this ubiquitin-like conjugation system is a widely used marker for autophagy. However, the ATG 16L complex along with other ATGs like ATG 18 and ATG 21 prevent the premature cleavage of ATG8-PE by the cysteine protease, Atg4 until the autophagosome is deemed complete.
蛋白别名: A16L1; APG 16-L1; APG16-like 1; APG16L beta; APG16L isoforms 1; atg16; ATG16 autophagy related 16-like 1; autophagy related 16-like 1; Autophagy-related protein 16-1; hCG_1817841; WD repeat domain 30
基因别名: APG16L; ATG16A; ATG16L; ATG16L1; IBD10; UNQ9393/PRO34307; WDR30
UniProt ID: (Human) Q676U5
Entrez Gene ID: (Human) 55054