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Invitrogen
Human ATP11C (aa 930-957) Control Fragment Recombinant Protein
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产品信息
RP-95435
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
EQHINIDTLTSDPRLYMKISGNAMLQLG
标签
His-ABP-tag
分类
Recombinant
类型
Protein
纯度
>80% by SDS-PAGE and Coomassie blue staining
偶联物
形式
Liquid
浓度
≥5.0 mg/mL
纯化类型
purified
保存液
1M urea/PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Highest antigen sequence indentity to the following orthologs: Mouse (93%), Rat (93%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-56569. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
靶标信息
The ATP11C gene encodes a protein that belongs to the P4-ATPase family, specifically functioning as a phospholipid-transporting ATPase. ATP11C plays a critical role in the maintenance of phospholipid asymmetry across the cell membrane by transporting aminophospholipids from the outer leaflet to the inner leaflet of the plasma membrane. This activity is essential for various biological processes, including cell membrane integrity, cell signaling, and apoptosis. ATP11C is particularly important in hematopoiesis, influencing the development of B cells and red blood cells. Mutations or dysregulation in ATP11C can lead to disruptions in cell membrane dynamics and are associated with immunological disorders and anemia. Research on ATP11C continues to focus on its role in phospholipid transport and its implications for cellular function and disease, particularly in the context of blood-related disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATPase class VI type 11C; ATPase IQ; ATPase, class VI, type 11C; P4-ATPase flippase complex alpha subunit ATP11C; Phospholipid-transporting ATPase IG; probable phospholipid-transporting ATPase IG
基因别名: ATP11C; ATPIG; ATPIQ
UniProt ID: (Human) Q8NB49
Entrez Gene ID: (Human) 286410
