This peptide corresponds to 16 amino acids near the carboxy terminus of human Acinus (CP).
PEP-0063 can be used as a blocking peptide with polyclonal antibody PA5-19938.
ACINUS (apoptotic chromatin condensation inducer in the nucleus) is an induced of chromatin condensation. ACINUS is cleaved by caspase-3 and an additional unknown protease generating a small active peptide, p17, which causes chromatin condensation in vitro when it is added to purified nuclei. ACINUS also induces apoptotic chromatin condensation in cells. ACINUS is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse.