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产品信息
PEP-0383
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
产品详细信息
This peptide corresponds to 14 amino acids near the carboxy terminus of human Bfl-1.^M
^M
PEP-0383 can be used as a blocking peptide with polyclonal antibody PA5-20268.
靶标信息
Bcl-2 related Protein A1 is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Bcl-2-like protein 5; Bcl-2-related protein A1; Bcl2-L-5; BCL2-related protein A1; GRS protein; hematopoietic BCL2-related protein A1; Hemopoietic-specific early response protein; Protein BFL-1; Protein GRS
基因别名: ACC-1; ACC-2; ACC1; ACC2; BCL2A1; BCL2L5; BFL1; GRS; HBPA1
UniProt ID: (Human) Q16548
Entrez Gene ID: (Human) 597
