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产品信息
PEP-143
产品规格
种属反应
Human
宿主/亚型
Artificial Control
分类
Synthetic
类型
Peptide
偶联物
Unconjugated
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
purified
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
产品详细信息
PEP-143 is a 14 amino acid synthetic phospho-peptide whose sequence corresponds to residues 123-136 of human CREB with serine 133 being phosphorylated. The sequence of this peptide is (amino to carboxy terminus): K (123)-R-R-E-I-L-S-R-R-P-S (p)-Y-R-K (136)
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human CREB, catalog # PA1-851B. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
靶标信息
CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB is involved in different cellular processes including the synchronization of circadian rhythmicity, differentiation of adipose cells, and learning and memory. In humans, the gene is located on the q arm of chromosome 2. Diseases associated with CREB dysfunction include Alzheimer's Disease, histiocytoma and soft tissue melanoma.
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生物信息学
蛋白别名: active transcription factor CREB; cAMP-response element-binding protein-1; CREB-1; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; Cyclic AMP-responsive element-binding protein 1; htCREB; MGC9284; OTTHUMP00000206661; OTTHUMP00000206662; OTTHUMP00000206667; transactivator protein
基因别名: CREB; CREB-1; CREB1
UniProt ID: (Human) P21934
Entrez Gene ID: (Human) 1385
