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For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
Protein Form: Full Length
Casein kinase I (also designated CKI) and casein kinase II (also designated CKII) compose a family of serine/ threonine protein kinases which are present in all eukaryotes examined to date. CKI family members, which include CKI alpha, gamma, epsilon and delta, have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. CKII is usually expressed as a tetrameric complex consisting of either an alpha2 beta2 or an alpha alpha' beta2 structure. The alpha catalytic subunit is stimulated by the beta regulatory subunit, which undergoes autophosphorylation. CKII activity is high in the cytosol and nucleus of proliferating and differentiating cells. CKII is known to phosphorylate more than 100 different substrates including nuclear oncoproteins, transcription factors and enzymes involved in DNA metabolism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: casein kinase 1, gamma 1; Casein kinase I isoform gamma-1; CK I gamma1; CK-I gamma1; CK1G1; CKI gamma 1; CKI gamma-1; CKI gamma1; CKI- gamma1; CKI-gamma 1; CKI-gamma-1; KC1G1
基因别名: CK1gamma1; CSNK1G1
UniProt ID: (Human) Q9HCP0
Entrez Gene ID: (Human) 53944