This peptide corresponds to 15 amino acids near the center of human caspase-6.
PEP-0235 can be used as a blocking peptide with polyclonal antibody PA5-20117.
Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.
蛋白别名: Apoptotic protease Mch-2; CASP-6; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease; Caspase-6; Caspase-6 subunit p10; Caspase-6 subunit p11; Caspase-6 subunit p18; Caspase-6 subunit p20; mCASP-6
基因别名: CASP6; MCH2
UniProt ID: (Human) P55212
Entrez Gene ID: (Human) 839