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This peptide corresponds to 17 amino acids near the center of human DDX60.
PEP-1484 can be used as a blocking peptide with polyclonal antibody PA5-34442.
DDX60 is a DEXD/H Box RNA helicase and the human homolog of the S. cerevisiae Ski2, a cofactor of RNA exosome. Expression of DDX60 increases after viral infection and binds to endogenous RIG-I, a cytoplasmic viral RNA sensor, as well as other RIG-I-like receptors such as MDA5 and LGP2. These proteins activate TBK1 and IKK-e, signaling IRF3 and NF-kB-responsive genes in the innate immune response pathway. DDX60 is required for the RIG-I- or MDA5-dependent response to viral infection, but is dispensable for TLR3-mediated signaling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DEAD (Asp-Glu-Ala-Asp) box polypeptide 60; DEAD box protein 60; DEAD-box helicase 60; Probable ATP-dependent RNA helicase DDX60
基因别名: DDX60
UniProt ID: (Human) Q8IY21
Entrez Gene ID: (Human) 55601