Product References
Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles.
Cancer & metabolism
Ali HA,Karasinska JM,Topham JT,Johal D,Kalloger S,Metcalfe A,Warren CS,Miyagi A,Tao LV,Kevorkova M,Chafe SC,McDonald PC,Dedhar S,Parker SJ,Renouf DJ,Schaeffer DF
100-26 was used in Tissue/organ culture to investigate differences in metabolic profiles and transcriptomes in tumour models derived from patients with basal-like and classical tumours.
Thu Oct 03 00:00:00 UTC 2024
Secretion of WNT7A by UC-MSCs assist in promoting the endometrial epithelial regeneration.
iScience
Liu F,Lin Q,Shen S,Li Z,Xie X,Cheng Q,Wang L,Long Y,Wang J,Liu L
100-26 was used in In vitro experiments to design an extracellular matrix (ECM)-adhesion mimic hydrogel for intrauterine administration, which was more effective than direct injection in treating intrauterine adhesions.
Fri Jun 21 00:00:00 UTC 2024
Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization.
Cellular oncology (Dordrecht, Netherlands)
McAloney CA,Makkawi R,Budhathoki Y,Cannon MV,Franz EM,Gross AC,Cam M,Vetter TA,Duhen R,Davies AE,Roberts RD
100-26 was used in In vitro experiments to develop therapeutic strategies that prevent and treat metastasis by identifying mechanisms that facilitate survival of disseminated tumour cells.
Thu Feb 01 00:00:00 UTC 2024
Helicobacter pylori induces the expression of Lgr5 and stem cell properties in gastric target cells.
Life science alliance
Nascakova Z,He J,Papa G,Francas B,Azizi F,Müller A
100-26 was used in Tissue/organ culture to indicate that H. pylori has stemness-inducing properties that depend on its ability to activate NF-κB signaling.
Fri Nov 01 00:00:00 UTC 2024
Simultaneous establishment of pancreatic cancer organoid and cancer-associated fibroblast using a single-pass endoscopic ultrasound-guided fine-needle biopsy specimen.
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
Kim S,Woo KJ,Yang CM,Park SH,Hwang JC,Yoo BM,Kim JH,Lee D,Yang MJ
100-26 was used in Cell Culture to demonstrate that the coestablishment of PDOs and CAFs is feasible even with a single-pass EUS-FNB sample, implying an expanding role of endoscopists in future precision medicine.
Wed Nov 01 00:00:00 UTC 2023
Role of PDGFRA+ cells and a CD55+ PDGFRALo fraction in the gastric mesenchymal niche.
Nature communications
Manieri E,Tie G,Malagola E,Seruggia D,Madha S,Maglieri A,Huang K,Fujiwara Y,Zhang K,Orkin SH,Wang TC,He R,McCarthy N,Shivdasani RA
100-26 was used in Cell Culture to shed light on spatial, molecular, and functional organization of gastric mesenchyme and the spectrum of signaling sources for epithelial support.
Sat Dec 02 00:00:00 UTC 2023
Influence of glycan structure on the colonization of Streptococcus pneumoniae on human respiratory epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America
Chun YY,Tan KS,Yu L,Pang M,Wong MHM,Nakamoto R,Chua WZ,Huee-Ping Wong A,Lew ZZR,Ong HH,Chow VT,Tran T,Yun Wang D,Sham LT
100-26 was used in Cell Culture to reveal glycomotifs of surface polysaccharides that are likely to be important for colonization and survival in the human airway.
Tue Mar 28 00:00:00 UTC 2023
miR-203 drives breast cancer cell differentiation.
Breast cancer research : BCR
Martínez-Illescas NG,Leal S,González P,Graña-Castro O,Muñoz-Oliveira JJ,Cortés-Peña A,Gómez-Gil M,Vega Z,Neva V,Romero A,Quintela-Fandino M,Ciruelos E,Sanz C,Aragón S,Sotolongo L,Jiménez S,Caleiras E,Mulero F,Sánchez C,Malumbres M,Salazar-Roa M
100-26 was used in Tissue/organ culture to report that miR-203 influences the self-renewal capacity, plasticity and differentiation potential of breast cancer cells and prevents tumor cell growth in vivo.
Fri Aug 04 00:00:00 UTC 2023
Initial Characterization of 3D Culture of Yolk Sac Tissue.
Animals : an open access journal from MDPI
Pereira VM,Pinto PAF,Motta LCB,Almeida MF,de Andrade AFC,Pavaneli APP,Ambrósio CE
100-26 was used in Cell Culture to standardise 3D culture techniques for the yolk sac in three domestic species (porcine, canine, and bovine) models.
Sat Apr 22 00:00:00 UTC 2023
Initial Characterization of 3D Culture of Yolk Sac Tissue.
Animals : an open access journal from MDPI
Pereira VM,Pinto PAF,Motta LCB,Almeida MF,de Andrade AFC,Pavaneli APP,Ambrósio CE
100-26 was used in Cell Culture to standardise 3D culture techniques for the yolk sac in three domestic species (porcine, canine, and bovine) models.
Sat Apr 22 00:00:00 UTC 2023
Initial Characterization of 3D Culture of Yolk Sac Tissue.
Animals : an open access journal from MDPI
Pereira VM,Pinto PAF,Motta LCB,Almeida MF,de Andrade AFC,Pavaneli APP,Ambrósio CE
100-26 was used in Cell Culture to standardise 3D culture techniques for the yolk sac in three domestic species (porcine, canine, and bovine) models.
Sat Apr 22 00:00:00 UTC 2023
Single-cell RNA sequencing reveals the developmental program underlying proximal-distal patterning of the human lung at the embryonic stage.
Cell research
Cao S,Feng H,Yi H,Pan M,Lin L,Zhang YS,Feng Z,Liang W,Cai B,Li Q,Xiong Z,Shen Q,Ke M,Zhao X,Chen H,He Q,Min M,Cai Q,Liu H,Wang J,Pei D,Chen J,Ma Y
100-26 was used in In vitro experiments to elucidate the cell fate bifurcation and maturation of airway and vascular smooth muscle progenitor cells at the early stage of lung development.
Thu Jun 01 00:00:00 UTC 2023
Generating human blastoids modeling blastocyst-stage embryos and implantation.
Nature protocols
Heidari Khoei H,Javali A,Kagawa H,Sommer TM,Sestini G,David L,Slovakova J,Novatchkova M,Scholte Op Reimer Y,Rivron N
100-26 was used in Cell Culture to describe how we formed human blastoids that (1) efficiently achieve the morphology of the blastocyst and (2) form lineages according to the pace and sequence of blastocyst development, (3) ultimately forming cells that transcriptionally reflect the blastocyst (preimplantation stage).
Mon May 01 00:00:00 UTC 2023
The tumor stroma influences immune cell distribution and recruitment in a PDAC-on-a-chip model.
Frontiers in immunology
Geyer M,Gaul LM,D Agosto SL,Corbo V,Queiroz K
100-26 was used in Tissue/organ culture to establish a 3D pancreatic ductal adenocarcinoma (PDAC) model cultured under flow, consisting of an endothelial tube, pancreatic stellate cells and PDAC organoids.
Mon May 22 00:00:00 UTC 2023
Salivary gland cancer organoids are valid for preclinical genotype-oriented medical precision trials.
iScience
Ishikawa T,Ogawa T,Shiihara M,Usubuchi H,Omori Y,Hirose K,Itoh T,Yoshida T,Nakanome A,Okoshi A,Higashi K,Ishii R,Rokugo M,Wakamori S,Okamura Y,Kinoshita K,Katori Y,Furukawa T
100-26 was used in Cell Culture to establish a translational model for testing molecular-targeted therapies by combining patient-derived organoids and genomic analyses of Salivary gland cancers.
Fri May 19 00:00:00 UTC 2023
Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2.
Cell research
Gu Y,Cao J,Zhang X,Gao H,Wang Y,Wang J,He J,Jiang X,Zhang J,Shen G,Yang J,Zheng X,Hu G,Zhu Y,Du S,Zhu Y,Zhang R,Xu J,Lan F,Qu D,Xu G,Zhao Y,Gao D,Xie Y,Luo M,Lu Z
Sat Jan 01 00:00:00 UTC 2022
An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy.
The Journal of experimental medicine
Khalil BD,Sanchez R,Rahman T,Rodriguez-Tirado C,Moritsch S,Martinez AR,Miles B,Farias E,Mezei M,Nobre AR,Singh D,Kale N,Sproll KC,Sosa MS,Aguirre-Ghiso JA
Mon Jan 03 00:00:00 UTC 2022
An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy.
The Journal of experimental medicine
Khalil BD,Sanchez R,Rahman T,Rodriguez-Tirado C,Moritsch S,Martinez AR,Miles B,Farias E,Mezei M,Nobre AR,Singh D,Kale N,Sproll KC,Sosa MS,Aguirre-Ghiso JA
Mon Jan 03 00:00:00 UTC 2022
Biliary organoids uncover delayed epithelial development and barrier function in biliary atresia.
Hepatology (Baltimore, Md.)
Amarachintha SP,Mourya R,Ayabe H,Yang L,Luo Z,Li X,Thanekar U,Shivakumar P,Bezerra JA
Sat Jan 01 00:00:00 UTC 2022
SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling.
The EMBO journal
Sun D,Llora Batlle O,van den Ameele J,Thomas JC,He P,Lim K,Tang W,Xu C,Meyer KB,Teichmann SA,Marioni JC,Jackson SP,Brand AH,Rawlins EL
100-26 was used in Cell Culture to establish a new workflow for using primary human organoids to elucidate detailed functional mechanisms underlying normal development and disease.
Wed Nov 02 00:00:00 UTC 2022
Recapitulating hepatitis E virus-host interactions and facilitating antiviral drug discovery in human liver-derived organoids.
Science advances
Li P,Li Y,Wang Y,Liu J,Lavrijsen M,Li Y,Zhang R,Verstegen MMA,Wang Y,Li TC,Ma Z,Kainov DE,Bruno MJ,de Man RA,van der Laan LJW,Peppelenbosch MP,Pan Q
Fri Jan 21 00:00:00 UTC 2022
IL13 Acts Directly on Gastric Epithelial Cells to Promote Metaplasia Development During Chronic Gastritis.
Cellular and molecular gastroenterology and hepatology
Noto CN,Hoft SG,Bockerstett KA,Jackson NM,Ford EL,Vest LS,DiPaolo RJ
100-26 was used in In vitro experiments to show that neutralization of IL13 reduces metaplasia severity during chronic gastritis.
Mon Apr 04 00:00:00 UTC 2022
IL13 Acts Directly on Gastric Epithelial Cells to Promote Metaplasia Development During Chronic Gastritis.
Cellular and molecular gastroenterology and hepatology
Noto CN,Hoft SG,Bockerstett KA,Jackson NM,Ford EL,Vest LS,DiPaolo RJ
100-26 was used in In vitro experiments to show that neutralization of IL13 reduces metaplasia severity during chronic gastritis.
Mon Apr 04 00:00:00 UTC 2022
Growth factor dependency in mammary organoids regulates ductal morphogenesis during organ regeneration.
Scientific reports
Sahu S,Albaugh ME,Martin BK,Patel NL,Riffle L,Mackem S,Kalen JD,Sharan SK
100-26 was used in Cell Culture to conclude that understanding the function of growth factors in organoids provides novel insights to cell proliferation, stem cell maintenance, tissue repair and organ regeneration in vivo.
Tue May 03 00:00:00 UTC 2022
Generation, Maintenance and HBV Infection of Human Liver Organoids.
Bio-protocol
Romal S,Hossain T,Mahmoudi T
100-26 was used in Cell Culture to propose the use of human liver organoids as a platform for modeling HBV infection and related tumorigenesis.
Sun Mar 20 00:00:00 UTC 2022
RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state.
Nature communications
Belenguer G,Mastrogiovanni G,Pacini C,Hall Z,Dowbaj AM,Arnes-Benito R,Sljukic A,Prior N,Kakava S,Bradshaw CR,Davies S,Vacca M,Saeb-Parsy K,Koo BK,Huch M
Mon Jan 17 00:00:00 UTC 2022
RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state.
Nature communications
Belenguer G,Mastrogiovanni G,Pacini C,Hall Z,Dowbaj AM,Arnes-Benito R,Sljukic A,Prior N,Kakava S,Bradshaw CR,Davies S,Vacca M,Saeb-Parsy K,Koo BK,Huch M
Mon Jan 17 00:00:00 UTC 2022
Microvessels derived from hiPSCs are a novel source for angiogenesis and tissue regeneration.
Journal of tissue engineering
Gao X,Ma S,Xing X,Yang J,Xu X,Liang C,Yu Y,Liu L,Liao L,Tian W
100-26 was used in In vitro experiments to reveal that iMVs had remarkable similarities to natural blood vessels in structure and cellular composition, and were potent for vascular formation and self-organization.
Wed Jan 11 00:00:00 UTC 2023
Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states.
Nature communications
Song H,Weinstein HNW,Allegakoen P,Wadsworth MH,Xie J,Yang H,Castro EA,Lu KL,Stohr BA,Feng FY,Carroll PR,Wang B,Cooperberg MR,Shalek AK,Huang FW
Mon Jan 10 00:00:00 UTC 2022
In-Depth Comparison of Matrigel Dissolving Methods on Proteomic Profiling of Organoids.
Molecular & cellular proteomics : MCP
Wang M,Yu H,Zhang T,Cao L,Du Y,Xie Y,Ji J,Wu J
Sat Jan 01 00:00:00 UTC 2022
Human Organotypic Airway and Lung Organoid Cells of Bronchiolar and Alveolar Differentiation Are Permissive to Infection by Influenza and SARS-CoV-2 Respiratory Virus.
Frontiers in cellular and infection microbiology
Ekanger CT,Zhou F,Bohan D,Lotsberg ML,Ramnefjell M,Hoareau L,Røsland GV,Lu N,Aanerud M,Gärtner F,Salminen PR,Bentsen M,Halvorsen T,Ræder H,Akslen LA,Langeland N,Cox R,Maury W,Stuhr LEB,Lorens JB,Engelsen AST
100-26 was used in Immunohistochemistry to investigate virulent affects of SARS-CoV-2 mutations on organoid models.
Tue Apr 05 00:00:00 UTC 2022
Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia.
Life science alliance
Amatngalim GD,Rodenburg LW,Aalbers BL,Raeven HH,Aarts EM,Sarhane D,Spelier S,Lefferts JW,Silva IA,Nijenhuis W,Vrendenbarg S,Kruisselbrink E,Brunsveld JE,van Drunen CM,Michel S,de Winter-de Groot KM,Heijerman HG,Kapitein LC,Amaral MD,van der Ent CK,Beekman JM
100-26 was used in Cell Culture to define organoid culture conditions, with the growth factor/cytokine combination neuregulin-1lt;igt;βlt;/igt; and interleukin-1lt;igt;βlt;/igt;, which enabled consistent detection of CFTR modulator responses in nasal-airway organoid cultures from subjects with cystic fibrosis.
Wed Aug 03 00:00:00 UTC 2022
Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis.
Molecular cell
He D,Feng H,Sundberg B,Yang J,Powers J,Christian AH,Wilkinson JE,Monnin C,Avizonis D,Thomas CJ,Friedman RA,Kluger MD,Hollingsworth MA,Grandgenett PM,Klute KA,Toste FD,Chang CJ,Chio IIC
100-26 was used in Tissue/organ culture to demonstrate that methionine residues can act as reversible redox switches governing distinct signaling outcomes and that the MSRA-PKM2 axis serves as a regulatory nexus between redox biology and cancer metabolism to control tumor metastasis.
Thu Aug 18 00:00:00 UTC 2022
Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis.
Molecular cell
He D,Feng H,Sundberg B,Yang J,Powers J,Christian AH,Wilkinson JE,Monnin C,Avizonis D,Thomas CJ,Friedman RA,Kluger MD,Hollingsworth MA,Grandgenett PM,Klute KA,Toste FD,Chang CJ,Chio IIC
100-26 was used in Tissue/organ culture to demonstrate that methionine residues can act as reversible redox switches governing distinct signaling outcomes and that the MSRA-PKM2 axis serves as a regulatory nexus between redox biology and cancer metabolism to control tumor metastasis.
Thu Aug 18 00:00:00 UTC 2022
Stage-Specific Generation of Human Pluripotent Stem Cell Derived Lung Models to Measure CFTR Function.
Current protocols
Ngan SY,Quach HT,Laselva O,Huang EN,Mangos M,Xia S,Bear CE,Wong AP
Sat Jan 01 00:00:00 UTC 2022
Multifocal Organoid Capturing of Colon Cancer Reveals Pervasive Intratumoral Heterogenous Drug Responses.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Kim SC,Park JW,Seo HY,Kim M,Park JH,Kim GH,Lee JO,Shin YK,Bae JM,Koo BK,Jeong SY,Ku JL
100-26 was used in Cell Culture to indicate the importance of targeting common somatic driver mutations positioned in the trunk of all tumor subregional clones in parallel with a comprehensive understanding of the molecular intratumor heterogeneity (ITH) of each tumor.
Tue Feb 01 00:00:00 UTC 2022
Identification of a therapeutic interfering particle-A single-dose SARS-CoV-2 antiviral intervention with a high barrier to resistance.
Cell
Chaturvedi S,Vasen G,Pablo M,Chen X,Beutler N,Kumar A,Tanner E,Illouz S,Rahgoshay D,Burnett J,Holguin L,Chen PY,Ndjamen B,Ott M,Rodick R,Rogers T,Smith DM,Weinberger LS
100-26 was used in Cell Culture to provide proof of concept for a class of single-administration antivirals that may circumvent current requirements to continually update medical countermeasures against new variants.
Thu Dec 09 00:00:00 UTC 2021
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.
Cell
Koikawa K,Kibe S,Suizu F,Sekino N,Kim N,Manz TD,Pinch BJ,Akshinthala D,Verma A,Gaglia G,Nezu Y,Ke S,Qiu C,Ohuchida K,Oda Y,Lee TH,Wegiel B,Clohessy JG,London N,Santagata S,Wulf GM,Hidalgo M,Muthuswamy SK,Nakamura M,Gray NS,Zhou XZ,Lu KP
Thu Sep 02 00:00:00 UTC 2021
SARS-CoV-2 infection induces beta cell transdifferentiation.
Cell metabolism
Tang X,Uhl S,Zhang T,Xue D,Li B,Vandana JJ,Acklin JA,Bonnycastle LL,Narisu N,Erdos MR,Bram Y,Chandar V,Chong ACN,Lacko LA,Min Z,Lim JK,Borczuk AC,Xiang J,Naji A,Collins FS,Evans T,Liu C,tenOever BR,Schwartz RE,Chen S
Tue Aug 03 00:00:00 UTC 2021
Opposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia.
Nature cell biology
Chumduri C,Gurumurthy RK,Berger H,Dietrich O,Kumar N,Koster S,Brinkmann V,Hoffmann K,Drabkina M,Arampatzi P,Son D,Klemm U,Mollenkopf HJ,Herbst H,Mangler M,Vogel J,Saliba AE,Meyer TF
Mon Feb 01 00:00:00 UTC 2021
Opposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia.
Nature cell biology
Chumduri C,Gurumurthy RK,Berger H,Dietrich O,Kumar N,Koster S,Brinkmann V,Hoffmann K,Drabkina M,Arampatzi P,Son D,Klemm U,Mollenkopf HJ,Herbst H,Mangler M,Vogel J,Saliba AE,Meyer TF
Mon Feb 01 00:00:00 UTC 2021
Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration.
Nature cell biology
Choi J,Jang YJ,Dabrowska C,Iich E,Evans KV,Hall H,Janes SM,Simons BD,Koo BK,Kim J,Lee JH
Wed Sep 01 00:00:00 UTC 2021
Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration.
Nature cell biology
Choi J,Jang YJ,Dabrowska C,Iich E,Evans KV,Hall H,Janes SM,Simons BD,Koo BK,Kim J,Lee JH
Wed Sep 01 00:00:00 UTC 2021
Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation.
Cell stem cell
Cordero-Espinoza L,Dowbaj AM,Kohler TN,Strauss B,Sarlidou O,Belenguer G,Pacini C,Martins NP,Dobie R,Wilson-Kanamori JR,Butler R,Prior N,Serup P,Jug F,Henderson NC,Hollfelder F,Huch M
Thu Nov 04 00:00:00 UTC 2021
Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids.
Cell stem cell
Huang L,Desai R,Conrad DN,Leite NC,Akshinthala D,Lim CM,Gonzalez R,Muthuswamy LB,Gartner Z,Muthuswamy SK
100-26 was used in Tissue/organ culture to report induction of human pluripotent stem cells toward pancreatic ductal and acinar organoids that recapitulate properties of the neonatal exocrine pancreas.
Thu Jun 03 00:00:00 UTC 2021
Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids.
Cell stem cell
Huang L,Desai R,Conrad DN,Leite NC,Akshinthala D,Lim CM,Gonzalez R,Muthuswamy LB,Gartner Z,Muthuswamy SK
100-26 was used in Tissue/organ culture to report induction of human pluripotent stem cells toward pancreatic ductal and acinar organoids that recapitulate properties of the neonatal exocrine pancreas.
Thu Jun 03 00:00:00 UTC 2021
Core-shell hydrogel microfiber-expanded pluripotent stem cell-derived lung progenitors applicable to lung reconstruction in vivo.
Biomaterials
Ikeo S,Yamamoto Y,Ikeda K,Sone N,Korogi Y,Tomiyama L,Matsumoto H,Hirai T,Hagiwara M,Gotoh S
100-26 was used in Cell Culture to establish an expansion system of hLPs based on their three-dimensional culture in core-shell hydrogel microfibers, that ensures the maintenance of their bipotency for differentiation into alveolar and airway epithelial cells including alveolar type II (AT2) cells.
Wed Sep 01 00:00:00 UTC 2021
A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America
Murakami K,Terakado Y,Saito K,Jomen Y,Takeda H,Oshima M,Barker N
Tue Jan 26 00:00:00 UTC 2021
Modelling of primary ciliary dyskinesia using patient-derived airway organoids.
EMBO reports
van der Vaart J,Böttinger L,Geurts MH,van de Wetering WJ,Knoops K,Sachs N,Begthel H,Korving J,Lopez-Iglesias C,Peters PJ,Eitan K,Gileles-Hillel A,Clevers H
Mon Dec 06 00:00:00 UTC 2021
The biological process of lysine-tRNA charging is therapeutically targetable in liver cancer.
Liver international : official journal of the International Association for the Study of the Liver
Zhang R,Noordam L,Ou X,Ma B,Li Y,Das P,Shi S,Liu J,Wang L,Li P,Verstegen MMA,Reddy DS,van der Laan LJW,Peppelenbosch MP,Kwekkeboom J,Smits R,Pan Q
Fri Jan 01 00:00:00 UTC 2021
Directed induction of alveolar type I cells derived from pluripotent stem cells via Wnt signaling inhibition.
Stem cells (Dayton, Ohio)
Kanagaki S,Ikeo S,Suezawa T,Yamamoto Y,Seki M,Hirai T,Hagiwara M,Suzuki Y,Gotoh S
Mon Feb 01 00:00:00 UTC 2021
NEK7 Promotes Pancreatic Cancer Progression And Its Expression Is Correlated With Poor Prognosis.
Frontiers in oncology
Yan Z,Qu J,Li Z,Yi J,Su Y,Lin Q,Yu G,Lin Z,Yin W,Lu F,Liu J
100-26 was used in Cell Culture to indicate that NEK7 promotes pancreatic cancer progression and it may be a potential marker for PDAC prognosis.
Sat Jul 24 00:00:00 UTC 2021
Stable Long-Term Culture of Human Distal Airway Stem Cells for Transplantation.
Stem cells international
Zhou Y,Wang Y,Li D,Zhang T,Ma Y,Zuo W
Wed Sep 29 00:00:00 UTC 2021
Repositioning of duloxetine to target pancreatic stellate cells.
Oncology letters
Sagara A,Nakata K,Matsumoto S,Guan W,Shinkawa T,Iwamoto C,Ikenaga N,Ohuchida K,Nakamura M
100-26 was used in Tissue/organ culture to suggest that duloxetine may be a potential drug for suppressing PSC activation and pancreatic cancer growth.
Fri Oct 01 00:00:00 UTC 2021
Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy.
Nature communications
Krieger TG,Le Blanc S,Jabs J,Ten FW,Ishaque N,Jechow K,Debnath O,Leonhardt CS,Giri A,Eils R,Strobel O,Conrad C
Tue Oct 05 00:00:00 UTC 2021
NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma.
Cell reports
Schild T,McReynolds MR,Shea C,Low V,Schaffer BE,Asara JM,Piskounova E,Dephoure N,Rabinowitz JD,Gomes AP,Blenis J
Tue Jun 15 00:00:00 UTC 2021
Innervated mouse pancreas organoids as an ex vivo model to study pancreatic neuropathy in pancreatic cancer.
STAR protocols
Besikcioglu HE,Yurteri Ü,Munkhbaatar E,Ye L,Zhang F,Moretti A,Mota Reyes C,Özoğul C,Friess H,Ceyhan GO,Istvanffy R,Demir IE
100-26 was used in Cell Culture to specifically investigate neurogenesis, organoids are co-cultured with iPSCs-derived neural crest cells, while co-culture with dorsal root ganglia explants is used for comparing organoids with mature neurons.
Fri Dec 17 00:00:00 UTC 2021
Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer.
Cell
Raghavan S,Winter PS,Navia AW,Williams HL,DenAdel A,Lowder KE,Galvez-Reyes J,Kalekar RL,Mulugeta N,Kapner KS,Raghavan MS,Borah AA,Liu N,Väyrynen SA,Costa AD,Ng RWS,Wang J,Hill EK,Ragon DY,Brais LK,Jaeger AM,Spurr LF,Li YY,Cherniack AD,Booker MA,Cohen EF,Tolstorukov MY,Wakiro I,Rotem A,Johnson BE,McFarland JM,Sicinska ET,Jacks TE,Sullivan RJ,Shapiro GI,Clancy TE,Perez K,Rubinson DA,Ng K,Cleary JM,Crawford L,Manalis SR,Nowak JA,Wolpin BM,Hahn WC,Aguirre AJ,Shalek AK
100-26 was used in In vitro experiments to study distinct site and state-specific tumour microevironments in pancreatic cancer.
Thu Dec 09 00:00:00 UTC 2021
An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection.
Cell reports
Duan X,Tang X,Nair MS,Zhang T,Qiu Y,Zhang W,Wang P,Huang Y,Xiang J,Wang H,Schwartz RE,Ho DD,Evans T,Chen S
Tue Nov 09 00:00:00 UTC 2021
Deleterious Effects of SARS-CoV-2 Infection on Human Pancreatic Cells.
Frontiers in cellular and infection microbiology
Shaharuddin SH,Wang V,Santos RS,Gross A,Wang Y,Jawanda H,Zhang Y,Hasan W,Garcia G,Arumugaswami V,Sareen D
Thu Jul 22 00:00:00 UTC 2021
Inhibition Lysosomal Degradation of Clusterin by Protein Kinase D3 Promotes Triple-Negative Breast Cancer Tumor Growth.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Liu Y,Zhou Y,Ma X,Chen L
Mon Feb 01 00:00:00 UTC 2021
Protocol for generation of lung adenocarcinoma organoids from clinical samples.
STAR protocols
Li Z,Yu L,Chen D,Meng Z,Chen W,Huang W
Fri Mar 19 00:00:00 UTC 2021
Early invasion of the bladder wall by solitary bacteria protects UPEC from antibiotics and neutrophil swarms in an organoid model.
Cell reports
Sharma K,Thacker VV,Dhar N,Clapés Cabrer M,Dubois A,Signorino-Gelo F,Mullenders J,Knott GW,Clevers H,McKinney JD
Tue Jul 20 00:00:00 UTC 2021
Differentiation of human pluripotent stem cells into pancreatic duct-like organoids.
STAR protocols
Breunig M,Merkle J,Melzer MK,Heller S,Seufferlein T,Meier M,Hohwieler M,Kleger A
100-26 was used in In vitro experiments to describe a scalable in vitro differentiation protocol to guide human pluripotent stem cells stepwise into pancreatic duct-like organoids.
Fri Dec 17 00:00:00 UTC 2021
Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells.
Nature communications
Lee MO,Lee SG,Jung CR,Son YS,Ryu JW,Jung KB,Ahn JH,Oh JH,Lee HA,Lim JH,Kim J,Jang I,Choi J,Jung J,Park K,Lee B,Kim DS,Son MY,Cho HS
Fri Jul 23 00:00:00 UTC 2021
Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models.
Cell death & disease
Clark MP,Huynh T,Rao S,Mackiewicz L,Mason H,Romal S,Stutz MD,Ahn SH,Earnest L,Sozzi V,Littlejohn M,Tran BM,Wiedemann N,Vincan E,Torresi J,Netter HJ,Mahmoudi T,Revill P,Pellegrini M,Ebert G
Wed Jun 23 00:00:00 UTC 2021
Arginine Methyltransferase PRMT1 Regulates p53 Activity in Breast Cancer.
Life (Basel, Switzerland)
Liu LM,Tang Q,Hu X,Zhao JJ,Zhang Y,Ying GG,Zhang F
100-26 was used in Cell Culture to show that p53 function is regulated by PRMT1 in breast cancer cells.
Thu Aug 05 00:00:00 UTC 2021
Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression.
Nature communications
Bolis M,Bossi D,Vallerga A,Ceserani V,Cavalli M,Impellizzieri D,Di Rito L,Zoni E,Mosole S,Elia AR,Rinaldi A,Pereira Mestre R,D'Antonio E,Ferrari M,Stoffel F,Jermini F,Gillessen S,Bubendorf L,Schraml P,Calcinotto A,Corey E,Moch H,Spahn M,Thalmann G,Kruithof-de Julio M,Rubin MA,Theurillat JP
100-26 was used in Cell Culture to provide a user-friendly web-resource enabling the investigation of dynamic transcriptional perturbations linked to disease progression.
Thu Dec 02 00:00:00 UTC 2021
The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology.
Nature communications
Risbridger GP,Clark AK,Porter LH,Toivanen R,Bakshi A,Lister NL,Pook D,Pezaro CJ,Sandhu S,Keerthikumar S,Quezada Urban R,Papargiris M,Kraska J,Madsen HB,Wang H,Richards MG,Niranjan B,O'Dea S,Teng L,Wheelahan W,Li Z,Choo N,Ouyang JF,Thorne H,Devereux L,Hicks RJ,Sengupta S,Harewood L,Iddawala M,Azad AA,Goad J,Grummet J,Kourambas J,Kwan EM,Moon D,Murphy DG,Pedersen J,Clouston D,Norden S,Ryan A,Furic L,Goode DL,Frydenberg M,Lawrence MG,Taylor RA
Thu Aug 19 00:00:00 UTC 2021
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide.
Nature communications
Li F,Han M,Dai P,Xu W,He J,Tao X,Wu Y,Tong X,Xia X,Guo W,Zhou Y,Li Y,Zhu Y,Zhang X,Liu Z,Aji R,Cai X,Li Y,Qu D,Chen Y,Jiang S,Wang Q,Ji H,Xie Y,Sun Y,Lu L,Gao D
Mon Feb 08 00:00:00 UTC 2021
Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours.
Nature communications
Custers L,Khabirova E,Coorens THH,Oliver TRW,Calandrini C,Young MD,Vieira Braga FA,Ellis P,Mamanova L,Segers H,Maat A,Kool M,Hoving EW,van den Heuvel-Eibrink MM,Nicholson J,Straathof K,Hook L,de Krijger RR,Trayers C,Allinson K,Behjati S,Drost J
Wed Mar 03 00:00:00 UTC 2021
Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors.
Cell reports
Calandrini C,van Hooff SR,Paassen I,Ayyildiz D,Derakhshan S,Dolman MEM,Langenberg KPS,van de Ven M,de Heus C,Liv N,Kool M,de Krijger RR,Tytgat GAM,van den Heuvel-Eibrink MM,Molenaar JJ,Drost J
Tue Aug 24 00:00:00 UTC 2021
Precancerous liver diseases do not cause increased mutagenesis in liver stem cells.
Communications biology
Nguyen L,Jager M,Lieshout R,de Ruiter PE,Locati MD,Besselink N,van der Roest B,Janssen R,Boymans S,de Jonge J,IJzermans JNM,Doukas M,Verstegen MMA,van Boxtel R,van der Laan LJW,Cuppen E,Kuijk E
Thu Nov 18 00:00:00 UTC 2021
mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways.
Cell reports
Li K,Wu H,Wang A,Charron J,Mishina Y,Habib SL,Liu H,Li B
Tue May 04 00:00:00 UTC 2021
Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19.
bioRxiv : the preprint server for biology
Tindle C,Fuller M,Fonseca A,Taheri S,Ibeawuchi SR,Beutler N,Katkar G,Claire A,Castillo V,Hernandez M,Russo H,Duran J,Crotty Alexander LE,Tipps A,Lin G,Thistlethwaite PA,Chattopadhyay R,Rogers TF,Sahoo D,Ghosh P,Das S
Wed May 05 00:00:00 UTC 2021
Culture and analysis of kidney tubuloids and perfused tubuloid cells-on-a-chip.
Nature protocols
Gijzen L,Yousef Yengej FA,Schutgens F,Vormann MK,Ammerlaan CME,Nicolas A,Kurek D,Vulto P,Rookmaaker MB,Lanz HL,Verhaar MC,Clevers H
100-26 was used in Cell Culture to establish kidney tubloid culture from tissue and urine, and generate and characterise tabloid cell-derived 3D tubular structures in a perfused microfluidic multi-chip platform.
Thu Apr 01 00:00:00 UTC 2021
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy.
Nature communications
Tajan M,Hennequart M,Cheung EC,Zani F,Hock AK,Legrave N,Maddocks ODK,Ridgway RA,Athineos D,Suárez-Bonnet A,Ludwig RL,Novellasdemunt L,Angelis N,Li VSW,Vlachogiannis G,Valeri N,Mainolfi N,Suri V,Friedman A,Manfredi M,Blyth K,Sansom OJ,Vousden KH
100-26 was used in Tissue/organ culture to show that inhibition of PHGDH, the first step in the SSP, cooperates with serine and glycine depletion to inhibit one-carbon metabolism and cancer growth.
Thu Jan 14 00:00:00 UTC 2021
Patient-derived xenografts and organoids model therapy response in prostate cancer.
Nature communications
Karkampouna S,La Manna F,Benjak A,Kiener M,De Menna M,Zoni E,Grosjean J,Klima I,Garofoli A,Bolis M,Vallerga A,Theurillat JP,De Filippo MR,Genitsch V,Keller D,Booij TH,Stirnimann CU,Eng K,Sboner A,Ng CKY,Piscuoglio S,Gray PC,Spahn M,Rubin MA,Thalmann GN,Kruithof-de Julio M
Thu Feb 18 00:00:00 UTC 2021
Improved Models of Human Endometrial Organoids Based on Hydrogels from Decellularized Endometrium.
Journal of personalized medicine
Francés-Herrero E,Juárez-Barber E,Campo H,López-Martínez S,de Miguel-Gómez L,Faus A,Pellicer A,Ferrero H,Cervelló I
Thu Jun 03 00:00:00 UTC 2021
Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition.
Cell reports
Waters AM,Khatib TO,Papke B,Goodwin CM,Hobbs GA,Diehl JN,Yang R,Edwards AC,Walsh KH,Sulahian R,McFarland JM,Kapner KS,Gilbert TSK,Stalnecker CA,Javaid S,Barkovskaya A,Grover KR,Hibshman PS,Blake DR,Schaefer A,Nowak KM,Klomp JE,Hayes TK,Kassner M,Tang N,Tanaseichuk O,Chen K,Zhou Y,Kalkat M,Herring LE,Graves LM,Penn LZ,Yin HH,Aguirre AJ,Hahn WC,Cox AD,Der CJ
Tue Jun 29 00:00:00 UTC 2021
Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening.
Cell reports
Ebisudani T,Sugimoto S,Haga K,Mitsuishi A,Takai-Todaka R,Fujii M,Toshimitsu K,Hamamoto J,Sugihara K,Hishida T,Asamura H,Fukunaga K,Yasuda H,Katayama K,Sato T
100-26 was used in In vitro experiments to establish an efficient human alveolosphere culture method and sphere-based drug testing platform for SARS-CoV-2.
Tue Jun 08 00:00:00 UTC 2021
Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution.
Cell reports
Busslinger GA,Weusten BLA,Bogte A,Begthel H,Brosens LAA,Clevers H
Tue Mar 09 00:00:00 UTC 2021
Pluripotent stem cell-derived endometrial stromal fibroblasts in a cyclic, hormone-responsive, coculture model of human decidua.
Cell reports
Cheung VC,Peng CY,Marinić M,Sakabe NJ,Aneas I,Lynch VJ,Ober C,Nobrega MA,Kessler JA
Tue May 18 00:00:00 UTC 2021
Homeostatic mini-intestines through scaffold-guided organoid morphogenesis.
Nature
Nikolaev M,Mitrofanova O,Broguiere N,Geraldo S,Dutta D,Tabata Y,Elci B,Brandenberg N,Kolotuev I,Gjorevski N,Clevers H,Lutolf MP
Tue Sep 01 00:00:00 UTC 2020
Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer.
Cell
Ruscetti M,Morris JP,Mezzadra R,Russell J,Leibold J,Romesser PB,Simon J,Kulick A,Ho YJ,Fennell M,Li J,Norgard RJ,Wilkinson JE,Alonso-Curbelo D,Sridharan R,Heller DA,de Stanchina E,Stanger BZ,Sherr CJ,Lowe SW
100-26 was used in Cell Culture to show that a combination of MEK and CDK4/6 inhibitors that target KRAS-directed oncogenic signaling can suppress PDAC proliferation through induction of retinoblastoma (RB) protein-mediated senescence.
Thu Apr 16 00:00:00 UTC 2020
An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping.
Cell
Kawasaki K,Toshimitsu K,Matano M,Fujita M,Fujii M,Togasaki K,Ebisudani T,Shimokawa M,Takano A,Takahashi S,Ohta Y,Nanki K,Igarashi R,Ishimaru K,Ishida H,Sukawa Y,Sugimoto S,Saito Y,Maejima K,Sasagawa S,Lee H,Kim HG,Ha K,Hamamoto J,Fukunaga K,Maekawa A,Tanabe M,Ishihara S,Hamamoto Y,Yasuda H,Sekine S,Kudo A,Kitagawa Y,Kanai T,Nakagawa H,Sato T
Wed Nov 25 00:00:00 UTC 2020
Snake Venom Gland Organoids.
Cell
Post Y,Puschhof J,Beumer J,Kerkkamp HM,de Bakker MAG,Slagboom J,de Barbanson B,Wevers NR,Spijkers XM,Olivier T,Kazandjian TD,Ainsworth S,Iglesias CL,van de Wetering WJ,Heinz MC,van Ineveld RL,van Kleef RGDM,Begthel H,Korving J,Bar-Ephraim YE,Getreuer W,Rios AC,Westerink RHS,Snippert HJG,van Oudenaarden A,Peters PJ,Vonk FJ,Kool J,Richardson MK,Casewell NR,Clevers H
Thu Jan 23 00:00:00 UTC 2020
The Repertoire of Serous Ovarian Cancer Non-genetic Heterogeneity Revealed by Single-Cell Sequencing of Normal Fallopian Tube Epithelial Cells.
Cancer cell
Hu Z,Artibani M,Alsaadi A,Wietek N,Morotti M,Shi T,Zhong Z,Santana Gonzalez L,El-Sahhar S,Carrami EM,Mallett G,Feng Y,Masuda K,Zheng Y,Chong K,Damato S,Dhar S,Campo L,Garruto Campanile R,Soleymani Majd H,Rai V,Maldonado-Perez D,Jones S,Cerundolo V,Sauka-Spengler T,Yau C,Ahmed AA
Mon Feb 10 00:00:00 UTC 2020
Emergence of a High-Plasticity Cell State during Lung Cancer Evolution.
Cancer cell
Marjanovic ND,Hofree M,Chan JE,Canner D,Wu K,Trakala M,Hartmann GG,Smith OC,Kim JY,Evans KV,Hudson A,Ashenberg O,Porter CBM,Bejnood A,Subramanian A,Pitter K,Yan Y,Delorey T,Phillips DR,Shah N,Chaudhary O,Tsankov A,Hollmann T,Rekhtman N,Massion PP,Poirier JT,Mazutis L,Li R,Lee JH,Amon A,Rudin CM,Jacks T,Regev A,Tammela T
Mon Aug 10 00:00:00 UTC 2020
A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation.
Cell stem cell
Miao ZF,Adkins-Threats M,Burclaff JR,Osaki LH,Sun JX,Kefalov Y,He Z,Wang ZN,Mills JC
100-26 was used in Tissue/organ culture to show that the energy sensor AMP kinase (AMPK) governs gastric epithelial progenitor differentiation.
Thu Jun 04 00:00:00 UTC 2020
Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2.
Cell stem cell
Youk J,Kim T,Evans KV,Jeong YI,Hur Y,Hong SP,Kim JH,Yi K,Kim SY,Na KJ,Bleazard T,Kim HM,Fellows M,Mahbubani KT,Saeb-Parsy K,Kim SY,Kim YT,Koh GY,Choi BS,Ju YS,Lee JH
100-26 was used in Cell Culture to provide deep insights into the pathogenesis of SARS-CoV-2 and the application of defined 3D hAT2 cultures as models for respiratory diseases.
Thu Dec 03 00:00:00 UTC 2020
Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2.
Cell stem cell
Youk J,Kim T,Evans KV,Jeong YI,Hur Y,Hong SP,Kim JH,Yi K,Kim SY,Na KJ,Bleazard T,Kim HM,Fellows M,Mahbubani KT,Saeb-Parsy K,Kim SY,Kim YT,Koh GY,Choi BS,Ju YS,Lee JH
100-26 was used in Cell Culture to provide deep insights into the pathogenesis of SARS-CoV-2 and the application of defined 3D hAT2 cultures as models for respiratory diseases.
Thu Dec 03 00:00:00 UTC 2020
Antagonism of interferon signaling by fibroblast growth factors promotes viral replication.
EMBO molecular medicine
Maddaluno L,Urwyler C,Rauschendorfer T,Meyer M,Stefanova D,Spörri R,Wietecha M,Ferrarese L,Stoycheva D,Bender D,Li N,Strittmatter G,Nasirujjaman K,Beer HD,Staeheli P,Hildt E,Oxenius A,Werner S
Mon Sep 07 00:00:00 UTC 2020
Antagonism of interferon signaling by fibroblast growth factors promotes viral replication.
EMBO molecular medicine
Maddaluno L,Urwyler C,Rauschendorfer T,Meyer M,Stefanova D,Spörri R,Wietecha M,Ferrarese L,Stoycheva D,Bender D,Li N,Strittmatter G,Nasirujjaman K,Beer HD,Staeheli P,Hildt E,Oxenius A,Werner S
Mon Sep 07 00:00:00 UTC 2020
Stable expansion of high-grade serous ovarian cancer organoids requires a low-Wnt environment.
The EMBO journal
Hoffmann K,Berger H,Kulbe H,Thillainadarasan S,Mollenkopf HJ,Zemojtel T,Taube E,Darb-Esfahani S,Mangler M,Sehouli J,Chekerov R,Braicu EI,Meyer TF,Kessler M
Mon Mar 16 00:00:00 UTC 2020
Cellulose Nanofibril Hydrogel Promotes Hepatic Differentiation of Human Liver Organoids.
Advanced healthcare materials
Krüger M,Oosterhoff LA,van Wolferen ME,Schiele SA,Walther A,Geijsen N,De Laporte L,van der Laan LJW,Kock LM,Spee B
Sun Mar 01 00:00:00 UTC 2020
FGF9 and FGF10 activate distinct signaling pathways to direct lung epithelial specification and branching.
Science signaling
Yin Y,Ornitz DM
100-26 was used in In vitro experiments to investigate the effects of fibroblast growth factors 9 and 10 on direct lung epithelial specification and branching.
Tue Mar 03 00:00:00 UTC 2020
Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening.
Journal of molecular cell biology
Du Y,Li X,Niu Q,Mo X,Qui M,Ma T,Kuo CJ,Fu H
Sat Aug 01 00:00:00 UTC 2020
Adaptation within embryonic and neonatal heart environment reveals alternative fates for adult c-kit+ cardiac interstitial cells.
Stem cells translational medicine
Wang BJ,Alvarez R,Muliono A,Sengphanith S,Monsanto MM,Weeks J,Sacripanti R,Sussman MA
100-26 was used in Cell Culture to investigate cardiac interstitial cell transcriptome in the heart.
Fri May 01 00:00:00 UTC 2020
Adaptation within embryonic and neonatal heart environment reveals alternative fates for adult c-kit+ cardiac interstitial cells.
Stem cells translational medicine
Wang BJ,Alvarez R,Muliono A,Sengphanith S,Monsanto MM,Weeks J,Sacripanti R,Sussman MA
100-26 was used in Cell Culture to investigate cardiac interstitial cell transcriptome in the heart.
Fri May 01 00:00:00 UTC 2020
3D Cell Culture Models Demonstrate a Role for FGF and WNT Signaling in Regulation of Lung Epithelial Cell Fate and Morphogenesis.
Frontiers in cell and developmental biology
Rabata A,Fedr R,Soucek K,Hampl A,Koledova Z
100-26 was used in Tissue/organ culture to present lung 3D cell culture models as useful tools to study the role and interplay of signaling pathways in postnatal lung development and homeostasis, and we reveal distinct roles for FGF ligands in regulation of mouse lung morphogenesis and differentiation ex vivo.
Mon Sep 28 00:00:00 UTC 2020
Basal-like and classical cells coexist in pancreatic cancer revealed by single-cell analysis on biopsy-derived pancreatic cancer organoids from the classical subtype.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Juiz N,Elkaoutari A,Bigonnet M,Gayet O,Roques J,Nicolle R,Iovanna J,Dusetti N
Tue Sep 01 00:00:00 UTC 2020
Generation and characterization of a cell line from an intraductal tubulopapillary neoplasm of the pancreas.
Laboratory investigation; a journal of technical methods and pathology
Felsenstein M,Trujillo MA,Huang B,Nanda N,Jiang Z,Jeong YJ,Pflüger M,Goggins MG,Hruban RH,Thompson ED,Heaphy CM,Roberts NJ,Wood LD
100-26 was used in Cell Culture to study the generation as well as the characterization of cell line from a human pancreatic ITPN.
Wed Jul 01 00:00:00 UTC 2020
The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress.
Nature communications
Bauer M,Nascakova Z,Mihai AI,Cheng PF,Levesque MP,Lampart S,Hurwitz R,Pfannkuch L,Dobrovolna J,Jacobs M,Bartfeld S,Dohlman A,Shen X,Gall AA,Salama NR,Töpfer A,Weber A,Meyer TF,Janscak P,Müller A
Fri Oct 09 00:00:00 UTC 2020
Murine- and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma.
Cancers
Holokai L,Chakrabarti J,Lundy J,Croagh D,Adhikary P,Richards SS,Woodson C,Steele N,Kuester R,Scott A,Khreiss M,Frankel T,Merchant J,Jenkins BJ,Wang J,Shroff RT,Ahmad SA,Zavros Y
100-26 was used in Cell Culture to develop a clinically relevant in vitro organoid model to specifically target mechanisms that deplete myeloid-derived suppressor cells as a therapeutic strategy for pancreatic ductal adenocarcinoma.
Thu Dec 17 00:00:00 UTC 2020
Murine- and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma.
Cancers
Holokai L,Chakrabarti J,Lundy J,Croagh D,Adhikary P,Richards SS,Woodson C,Steele N,Kuester R,Scott A,Khreiss M,Frankel T,Merchant J,Jenkins BJ,Wang J,Shroff RT,Ahmad SA,Zavros Y
100-26 was used in Cell Culture to develop a clinically relevant in vitro organoid model to specifically target mechanisms that deplete myeloid-derived suppressor cells as a therapeutic strategy for pancreatic ductal adenocarcinoma.
Thu Dec 17 00:00:00 UTC 2020
The mutational impact of culturing human pluripotent and adult stem cells.
Nature communications
Kuijk E,Jager M,van der Roest B,Locati MD,Van Hoeck A,Korzelius J,Janssen R,Besselink N,Boymans S,van Boxtel R,Cuppen E
Tue May 19 00:00:00 UTC 2020
Fallopian Tube Basal Stem Cells Reproducing the Epithelial Sheets In Vitro-Stem Cell of Fallopian Epithelium.
Biomolecules
Zhu M,Iwano T,Takeda S
100-26 was used in Cell Culture to optimise the culture condition for the stable expansion of basal stem cells, and inducing differentiation of basal cells into polarized secretory and ciliated cells in the air-liquid interface (ALI) condition that suitable for long-term culture.
Thu Sep 03 00:00:00 UTC 2020
Mechano-modulatory synthetic niches for liver organoid derivation.
Nature communications
Sorrentino G,Rezakhani S,Yildiz E,Nuciforo S,Heim MH,Lutolf MP,Schoonjans K
Fri Jul 10 00:00:00 UTC 2020
In Vivo Cell Fate Tracing Provides No Evidence for Mesenchymal to Epithelial Transition in Adult Fallopian Tube and Uterus.
Cell reports
Ghosh A,Syed SM,Kumar M,Carpenter TJ,Teixeira JM,Houairia N,Negi S,Tanwar PS
100-26 was used in Cell Culture to show that there is no definitive evidence of mesenchymal to epithelial transition in the adult fallopian tube and uterine epithelium.
Tue May 12 00:00:00 UTC 2020
NK cells in pancreatic cancer demonstrate impaired cytotoxicity and a regulatory IL-10 phenotype.
Oncoimmunology
Marcon F,Zuo J,Pearce H,Nicol S,Margielewska-Davies S,Farhat M,Mahon B,Middleton G,Brown R,Roberts KJ,Moss P
100-26 was used in Cell Culture to analyze the phenotype and function of natural killer (NK) cells in the blood and in tumor tissue from patients with pancreatic ductal adenocarcinoma (PDAC).
Thu Nov 19 00:00:00 UTC 2020
MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression.
Nature communications
Chang KC,Diermeier SD,Yu AT,Brine LD,Russo S,Bhatia S,Alsudani H,Kostroff K,Bhuiya T,Brogi E,Pappin DJ,Bennett CF,Rigo F,Spector DL
Tue Dec 22 00:00:00 UTC 2020
microRNA-181c-5p promotes the formation of insulin-producing cells from human induced pluripotent stem cells by targeting smad7 and TGIF2.
Cell death & disease
Li N,Jiang D,He Q,He F,Li Y,Deng C,Li F
Mon Jun 15 00:00:00 UTC 2020
CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank.
Cell stem cell
Geurts MH,de Poel E,Amatngalim GD,Oka R,Meijers FM,Kruisselbrink E,van Mourik P,Berkers G,de Winter-de Groot KM,Michel S,Muilwijk D,Aalbers BL,Mullenders J,Boj SF,Suen SWF,Brunsveld JE,Janssens HM,Mall MA,Graeber SY,van Boxtel R,van der Ent CK,Beekman JM,Clevers H
Thu Apr 02 00:00:00 UTC 2020
WNT and inflammatory signaling distinguish human Fallopian tube epithelial cell populations.
Scientific reports
Rose IM,Bidarimath M,Webster A,Godwin AK,Flesken-Nikitin A,Nikitin AY
Wed Jun 17 00:00:00 UTC 2020
Bim, Puma and Noxa upregulation by Naftopidil sensitizes ovarian cancer to the BH3-mimetic ABT-737 and the MEK inhibitor Trametinib.
Cell death & disease
Florent R,Weiswald LB,Lambert B,Brotin E,Abeilard E,Louis MH,Babin G,Poulain L,N'Diaye M
Mon May 18 00:00:00 UTC 2020
In vitro expansion of pancreatic islet clusters facilitated by hormones and chemicals.
Cell discovery
Lin JY,Cheng J,Du YQ,Pan W,Zhang Z,Wang J,An J,Yang F,Xu YF,Lin H,An WT,Wang J,Yang Z,Chai RJ,Sha XY,Hu HL,Sun JP,Yu X
Tue Oct 03 00:00:00 UTC 2023
In vitro expansion of pancreatic islet clusters facilitated by hormones and chemicals.
Cell discovery
Lin JY,Cheng J,Du YQ,Pan W,Zhang Z,Wang J,An J,Yang F,Xu YF,Lin H,An WT,Wang J,Yang Z,Chai RJ,Sha XY,Hu HL,Sun JP,Yu X
Tue Oct 03 00:00:00 UTC 2023
Establishment of Pancreatic Organoids from Normal Tissue and Tumors.
STAR protocols
Driehuis E,Gracanin A,Vries RGJ,Clevers H,Boj SF
100-26 was used in Tissue/organ culture to detail the generation of pancreatic tumor organoid models that can be cryopreserved and serve as living biobank for drug screening.
Fri Dec 18 00:00:00 UTC 2020
Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer.
Cancer cell
Woolston A,Khan K,Spain G,Barber LJ,Griffiths B,Gonzalez-Exposito R,Hornsteiner L,Punta M,Patil Y,Newey A,Mansukhani S,Davies MN,Furness A,Sclafani F,Peckitt C,Jiménez M,Kouvelakis K,Ranftl R,Begum R,Rana I,Thomas J,Bryant A,Quezada S,Wotherspoon A,Khan N,Fotiadis N,Marafioti T,Powles T,Lise S,Calvo F,Guettler S,von Loga K,Rao S,Watkins D,Starling N,Chau I,Sadanandam A,Cunningham D,Gerlinger M
Mon Jul 08 00:00:00 UTC 2019
Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures.
Proceedings of the National Academy of Sciences of the United States of America
Boonekamp KE,Kretzschmar K,Wiener DJ,Asra P,Derakhshan S,Puschhof J,López-Iglesias C,Peters PJ,Basak O,Clevers H
Tue Jul 16 00:00:00 UTC 2019
Mouse and human urothelial cancer organoids: A tool for bladder cancer research.
Proceedings of the National Academy of Sciences of the United States of America
Mullenders J,de Jongh E,Brousali A,Roosen M,Blom JPA,Begthel H,Korving J,Jonges T,Kranenburg O,Meijer R,Clevers HC
Tue Mar 05 00:00:00 UTC 2019
Mouse and human urothelial cancer organoids: A tool for bladder cancer research.
Proceedings of the National Academy of Sciences of the United States of America
Mullenders J,de Jongh E,Brousali A,Roosen M,Blom JPA,Begthel H,Korving J,Jonges T,Kranenburg O,Meijer R,Clevers HC
Tue Mar 05 00:00:00 UTC 2019
Changes of tight junction and interleukin-8 expression using a human gastroid monolayer model of Helicobacter pylori infection.
Helicobacter
Uotani T,Murakami K,Uchida T,Tanaka S,Nagashima H,Zeng XL,Akada J,Estes MK,Graham DY,Yamaoka Y
Sat Jun 01 00:00:00 UTC 2019
Gene manipulation in liver ductal organoids by optimized recombinant adeno-associated virus vectors.
The Journal of biological chemistry
Wei J,Ran G,Wang X,Jiang N,Liang J,Lin X,Ling C,Zhao B
Fri Sep 20 00:00:00 UTC 2019
Controlling Epithelial Polarity: A Human Enteroid Model for Host-Pathogen Interactions.
Cell reports
Co JY,Margalef-Català M,Li X,Mah AT,Kuo CJ,Monack DM,Amieva MR
100-26 was used in In vitro experiments to develop a technique to reverse enteroid polarity in Human enteroids-epithelial spheroids so the apical surface everts to face the media.
Tue Feb 26 00:00:00 UTC 2019
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma.
Nature communications
Chan K,Robert F,Oertlin C,Kapeller-Libermann D,Avizonis D,Gutierrez J,Handly-Santana A,Doubrovin M,Park J,Schoepfer C,Da Silva B,Yao M,Gorton F,Shi J,Thomas CJ,Brown LE,Porco JA,Pollak M,Larsson O,Pelletier J,Chio IIC
Wed Nov 13 00:00:00 UTC 2019
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma.
Nature communications
Chan K,Robert F,Oertlin C,Kapeller-Libermann D,Avizonis D,Gutierrez J,Handly-Santana A,Doubrovin M,Park J,Schoepfer C,Da Silva B,Yao M,Gorton F,Shi J,Thomas CJ,Brown LE,Porco JA,Pollak M,Larsson O,Pelletier J,Chio IIC
Wed Nov 13 00:00:00 UTC 2019
Nuclear FGFR2 negatively regulates hypoxia-induced cell invasion in prostate cancer by interacting with HIF-1 and HIF-2.
Scientific reports
Lee JE,Shin SH,Shin HW,Chun YS,Park JW
Tue Mar 05 00:00:00 UTC 2019
Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia.
Nature communications
Soutto M,Chen Z,Bhat AA,Wang L,Zhu S,Gomaa A,Bates A,Bhat NS,Peng D,Belkhiri A,Piazuelo MB,Washington MK,Steven XC,Peek R,El-Rifai W
Wed Jul 10 00:00:00 UTC 2019
Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors.
Nature communications
Segal JM,Kent D,Wesche DJ,Ng SS,Serra M,Oulès B,Kar G,Emerton G,Blackford SJI,Darmanis S,Miquel R,Luong TV,Yamamoto R,Bonham A,Jassem W,Heaton N,Vigilante A,King A,Sancho R,Teichmann S,Quake SR,Nakauchi H,Rashid ST
Fri Jul 26 00:00:00 UTC 2019
A Dynamic 3D Tumor Spheroid Chip Enables More Accurate Nanomedicine Uptake Evaluation.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhuang J,Zhang J,Wu M,Zhang Y
Fri Nov 01 00:00:00 UTC 2019
Robust, Long-Term Culture of Endoderm-Derived Hepatic Organoids for Disease Modeling.
Stem cell reports
Akbari S,Sevinç GG,Ersoy N,Basak O,Kaplan K,Sevinç K,Ozel E,Sengun B,Enustun E,Ozcimen B,Bagriyanik A,Arslan N,Önder TT,Erdal E
Tue Oct 08 00:00:00 UTC 2019
Immunoevolution of mouse pancreatic organoid isografts from preinvasive to metastatic disease.
Scientific reports
Filippini D,Agosto S,Delfino P,Simbolo M,Piro G,Rusev B,Veghini L,Cantù C,Lupo F,Ugel S,De Sanctis F,Bronte V,Milella M,Tortora G,Scarpa A,Carbone C,Corbo V
Thu Aug 22 00:00:00 UTC 2019
Hedgehog Signaling Modulates Interleukin-33-Dependent Extrahepatic Bile Duct Cell Proliferation in Mice.
Hepatology communications
Razumilava N,Shiota J,Mohamad Zaki NH,Ocadiz-Ruiz R,Cieslak CM,Zakharia K,Allen BL,Gores GJ,Samuelson LC,Merchant JL
Fri Feb 01 00:00:00 UTC 2019
Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation.
Nature communications
Kessler M,Hoffmann K,Fritsche K,Brinkmann V,Mollenkopf HJ,Thieck O,Teixeira da Costa AR,Braicu EI,Sehouli J,Mangler M,Berger H,Meyer TF
Mon Mar 18 00:00:00 UTC 2019
FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes.
Scientific reports
Savchenko E,Teku GN,Boza-Serrano A,Russ K,Berns M,Deierborg T,Lamas NJ,Wichterle H,Rothstein J,Henderson CE,Vihinen M,Roybon L
Wed Jul 03 00:00:00 UTC 2019
FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes.
Scientific reports
Savchenko E,Teku GN,Boza-Serrano A,Russ K,Berns M,Deierborg T,Lamas NJ,Wichterle H,Rothstein J,Henderson CE,Vihinen M,Roybon L
Wed Jul 03 00:00:00 UTC 2019
Mesenchyme-free expansion and transplantation of adult alveolar progenitor cells: steps toward cell-based regenerative therapies.
NPJ Regenerative medicine
Weiner AI,Jackson SR,Zhao G,Quansah KK,Farshchian JN,Neupauer KM,Littauer EQ,Paris AJ,Liberti DC,Scott Worthen G,Morrisey EE,Vaughan AE
Tue Sep 29 00:00:00 UTC 2020
Estrogen and EGFR Pathways Regulate Notch Signaling in Opposing Directions for Multi-Ciliogenesis in the Fallopian Tube.
Cells
Zhu M,Iwano T,Takeda S
100-26 was used in Cell Culture to investigate the role of estrogen and epidermal growth factor on regulating cell differentiation using porcine fallopian tube epithelial cells.
Mon Aug 19 00:00:00 UTC 2019
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.
Cell
Sachs N,de Ligt J,Kopper O,Gogola E,Bounova G,Weeber F,Balgobind AV,Wind K,Gracanin A,Begthel H,Korving J,van Boxtel R,Duarte AA,Lelieveld D,van Hoeck A,Ernst RF,Blokzijl F,Nijman IJ,Hoogstraat M,van de Ven M,Egan DA,Zinzalla V,Moll J,Boj SF,Voest EE,Wessels L,van Diest PJ,Rottenberg S,Vries RGJ,Cuppen E,Clevers H
Thu Jan 11 00:00:00 UTC 2018
Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis.
Cell
Nanki K,Toshimitsu K,Takano A,Fujii M,Shimokawa M,Ohta Y,Matano M,Seino T,Nishikori S,Ishikawa K,Kawasaki K,Togasaki K,Takahashi S,Sukawa Y,Ishida H,Sugimoto S,Kawakubo H,Kim J,Kitagawa Y,Sekine S,Koo BK,Kanai T,Sato T
Thu Aug 09 00:00:00 UTC 2018
Prediction of DNA Repair Inhibitor Response in Short-Term Patient-Derived Ovarian Cancer Organoids.
Cancer discovery
Hill SJ,Decker B,Roberts EA,Horowitz NS,Muto MG,Worley MJ,Feltmate CM,Nucci MR,Swisher EM,Nguyen H,Yang C,Morizane R,Kochupurakkal BS,Do KT,Konstantinopoulos PA,Liu JF,Bonventre JV,Matulonis UA,Shapiro GI,Berkowitz RS,Crum CP,D'Andrea AD
100-26 was used in Tissue/organ culture to demonstrate a platform for functional profiling of DNA repair in short-term patient-derived high-grade serous ovarian cancer (HGSC) organoids as a means of assessing targetable defects in the parent tumors, offering more suitable treatment options.
Thu Nov 01 00:00:00 UTC 2018
Growth of Epithelial Organoids in a Defined Hydrogel.
Advanced materials (Deerfield Beach, Fla.)
Broguiere N,Isenmann L,Hirt C,Ringel T,Placzek S,Cavalli E,Ringnalda F,Villiger L,Züllig R,Lehmann R,Rogler G,Heim MH,Schüler J,Zenobi-Wong M,Schwank G
Mon Oct 01 00:00:00 UTC 2018
Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer.
The Journal of experimental medicine
Shee K,Yang W,Hinds JW,Hampsch RA,Varn FS,Traphagen NA,Patel K,Cheng C,Jenkins NP,Kettenbach AN,Demidenko E,Owens P,Faber AC,Golub TR,Straussman R,Miller TW
Mon Mar 05 00:00:00 UTC 2018
Lrig1 marks a population of gastric epithelial cells capable of long-term tissue maintenance and growth in vitro.
Scientific reports
Schweiger PJ,Clement DL,Page ME,Schepeler T,Zou X,Sirokmány G,Watt FM,Jensen KB
Mon Oct 15 00:00:00 UTC 2018
Generation of orthotopically functional salivary gland from embryonic stem cells.
Nature communications
Tanaka J,Ogawa M,Hojo H,Kawashima Y,Mabuchi Y,Hata K,Nakamura S,Yasuhara R,Takamatsu K,Irié T,Fukada T,Sakai T,Inoue T,Nishimura R,Ohara O,Saito I,Ohba S,Tsuji T,Mishima K
Thu Oct 11 00:00:00 UTC 2018
Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition.
Cell stem cell
Fujii M,Matano M,Toshimitsu K,Takano A,Mikami Y,Nishikori S,Sugimoto S,Sato T
100-26 was used in In vitro experiments to investigate maintenance of intestinal organoid culture with reflective cellular diversity.
Thu Dec 06 00:00:00 UTC 2018
TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma.
Cell reports
Somerville TDD,Xu Y,Miyabayashi K,Tiriac H,Cleary CR,Maia-Silva D,Milazzo JP,Tuveson DA,Vakoc CR
100-26 was used in Cell Culture to investigate the effects of transcription factor TP63 expression and reprogramming on pancreatic ductal adenocarcinoma.
Tue Nov 13 00:00:00 UTC 2018
Patient derived organoids to model rare prostate cancer phenotypes.
Nature communications
Puca L,Bareja R,Prandi D,Shaw R,Benelli M,Karthaus WR,Hess J,Sigouros M,Donoghue A,Kossai M,Gao D,Cyrta J,Sailer V,Vosoughi A,Pauli C,Churakova Y,Cheung C,Deonarine LD,McNary TJ,Rosati R,Tagawa ST,Nanus DM,Mosquera JM,Sawyers CL,Chen Y,Inghirami G,Rao RA,Grandori C,Elemento O,Sboner A,Demichelis F,Rubin MA,Beltran H
Tue Jun 19 00:00:00 UTC 2018
Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing.
Nature communications
Ishihara J,Ishihara A,Fukunaga K,Sasaki K,White MJV,Briquez PS,Hubbell JA
Mon Jun 04 00:00:00 UTC 2018
Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing.
Nature communications
Ishihara J,Ishihara A,Fukunaga K,Sasaki K,White MJV,Briquez PS,Hubbell JA
Mon Jun 04 00:00:00 UTC 2018
Overexpression of HER2 in the pancreas promotes development of intraductal papillary mucinous neoplasms in mice.
Scientific reports
Shibata W,Kinoshita H,Hikiba Y,Sato T,Ishii Y,Sue S,Sugimori M,Suzuki N,Sakitani K,Ijichi H,Mori R,Endo I,Maeda S
Wed Apr 18 00:00:00 UTC 2018
Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells.
Scientific reports
Azzarelli R,Rulands S,Nestorowa S,Davies J,Campinoti S,Gillotin S,Bonfanti P,Göttgens B,Huch M,Simons B,Philpott A
Thu Oct 18 00:00:00 UTC 2018
A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening.
Cell stem cell
Yan HHN,Siu HC,Law S,Ho SL,Yue SSK,Tsui WY,Chan D,Chan AS,Ma S,Lam KO,Bartfeld S,Man AHY,Lee BCH,Chan ASY,Wong JWH,Cheng PSW,Chan AKW,Zhang J,Shi J,Fan X,Kwong DLW,Mak TW,Yuen ST,Clevers H,Leung SY
100-26 was used in Cell Culture to provide a useful resource for studying both cancer cell biology and precision cancer therapy.
Thu Dec 06 00:00:00 UTC 2018
Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics.
Nature communications
Li X,Francies HE,Secrier M,Perner J,Miremadi A,Galeano-Dalmau N,Barendt WJ,Letchford L,Leyden GM,Goffin EK,Barthorpe A,Lightfoot H,Chen E,Gilbert J,Noorani A,Devonshire G,Bower L,Grantham A,MacRae S,Grehan N,Wedge DC,Fitzgerald RC,Garnett MJ
Mon Jul 30 00:00:00 UTC 2018
In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity.
Cell stem cell
Zhang K,Zhang L,Liu W,Ma X,Cen J,Sun Z,Wang C,Feng S,Zhang Z,Yue L,Sun L,Zhu Z,Chen X,Feng A,Wu J,Jiang Z,Li P,Cheng X,Gao D,Peng L,Hui L
100-26 was used in Cell Culture to study ideal medium conditions for human hepatocytes for proliferation in injured mouse liver.
Thu Dec 06 00:00:00 UTC 2018
Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis.
Cell
Roe JS,Hwang CI,Somerville TDD,Milazzo JP,Lee EJ,Da Silva B,Maiorino L,Tiriac H,Young CM,Miyabayashi K,Filippini D,Creighton B,Burkhart RA,Buscaglia JM,Kim EJ,Grem JL,Lazenby AJ,Grunkemeyer JA,Hollingsworth MA,Grandgenett PM,Egeblad M,Park Y,Tuveson DA,Vakoc CR
100-26 was used in Cell Culture to use an organoid culture system to investigate how transcription and the enhancer landscape become altered during discrete stages of disease progression in a PDA mouse model.
Thu Aug 24 00:00:00 UTC 2017
Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6.
Cell
Lee JH,Tammela T,Hofree M,Choi J,Marjanovic ND,Han S,Canner D,Wu K,Paschini M,Bhang DH,Jacks T,Regev A,Kim CF
Thu Sep 07 00:00:00 UTC 2017
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer.
The Journal of experimental medicine
Öhlund D,Handly-Santana A,Biffi G,Elyada E,Almeida AS,Ponz-Sarvise M,Corbo V,Oni TE,Hearn SA,Lee EJ,Chio II,Hwang CI,Tiriac H,Baker LA,Engle DD,Feig C,Kultti A,Egeblad M,Fearon DT,Crawford JM,Clevers H,Park Y,Tuveson DA
Mon Mar 06 00:00:00 UTC 2017
Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney.
Proceedings of the National Academy of Sciences of the United States of America
Schutgens F,Rookmaaker MB,Blokzijl F,van Boxtel R,Vries R,Cuppen E,Verhaar MC,Clevers H
Tue Dec 26 00:00:00 UTC 2017
WRN conditioned media is sufficient for in vitro propagation of intestinal organoids from large farm and small companion animals.
Biology open
Powell RH,Behnke MS
100-26 was used in Sample Preparation to investigate organoid development of intestinal crypts.
Mon May 15 00:00:00 UTC 2017
A miR-327-FGF10-FGFR2-mediated autocrine signaling mechanism controls white fat browning.
Nature communications
Fischer C,Seki T,Lim S,Nakamura M,Andersson P,Yang Y,Honek J,Wang Y,Gao Y,Chen F,Samani NJ,Zhang J,Miyake M,Oyadomari S,Yasue A,Li X,Zhang Y,Liu Y,Cao Y
Tue Dec 12 00:00:00 UTC 2017
HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells.
Nature communications
Lin Y,Fang ZP,Liu HJ,Wang LJ,Cheng Z,Tang N,Li T,Liu T,Han HX,Cao G,Liang L,Ding YQ,Zhou WJ
Fri Oct 27 00:00:00 UTC 2017
HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells.
Nature communications
Lin Y,Fang ZP,Liu HJ,Wang LJ,Cheng Z,Tang N,Li T,Liu T,Han HX,Cao G,Liang L,Ding YQ,Zhou WJ
Fri Oct 27 00:00:00 UTC 2017
Adult Mouse Liver Contains Two Distinct Populations of Cholangiocytes.
Stem cell reports
Li B,Dorrell C,Canaday PS,Pelz C,Haft A,Finegold M,Grompe M
Tue Aug 08 00:00:00 UTC 2017
In Vitro Propagation and Branching Morphogenesis from Single Ureteric Bud Cells.
Stem cell reports
Yuri S,Nishikawa M,Yanagawa N,Jo OD,Yanagawa N
Tue Feb 14 00:00:00 UTC 2017
Development of Hepatocyte-like Cell Derived from Human Induced Pluripotent Stem cell as a Host for Clinically Isolated Hepatitis C Virus.
Current protocols in stem cell biology
Sa-Ngiamsuntorn K,Hongeng S,Wongkajornsilp A
100-26 was used in Cell Culture to devise protocols to generate hepatocyte-like cells from mesenchymal stem cells, with the ability to host hepatitis C virus clinical isolate or conventional JFH-1 genotype.
Mon Aug 14 00:00:00 UTC 2017
Organoid culture systems for prostate epithelial and cancer tissue.
Nature protocols
Drost J,Karthaus WR,Gao D,Driehuis E,Sawyers CL,Chen Y,Clevers H
100-26 was used in Cell Culture to describe a strategy for the generation of 3D prostate organoid cultures from a variety of cell types.
Mon Feb 01 00:00:00 UTC 2016
Fibroblast Growth Factor Ligand Dependent Proliferation and Chondrogenic Differentiation of Synovium-Derived Stem Cells and Concomitant Adaptation of Wnt/Mitogen-Activated Protein Kinase Signals.
Tissue engineering. Part A
Pizzute T,Li J,Zhang Y,Davis ME,Pei M
Mon Aug 01 00:00:00 UTC 2016
Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure.
Scientific reports
Kuijk EW,Rasmussen S,Blokzijl F,Huch M,Gehart H,Toonen P,Begthel H,Clevers H,Geurts AM,Cuppen E
Fri Feb 26 00:00:00 UTC 2016
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.
Nature protocols
Broutier L,Andersson-Rolf A,Hindley CJ,Boj SF,Clevers H,Koo BK,Huch M
Thu Sep 01 00:00:00 UTC 2016
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.
Nature protocols
Broutier L,Andersson-Rolf A,Hindley CJ,Boj SF,Clevers H,Koo BK,Huch M
Thu Sep 01 00:00:00 UTC 2016
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.
Nature protocols
Broutier L,Andersson-Rolf A,Hindley CJ,Boj SF,Clevers H,Koo BK,Huch M
Thu Sep 01 00:00:00 UTC 2016
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.
Nature protocols
Broutier L,Andersson-Rolf A,Hindley CJ,Boj SF,Clevers H,Koo BK,Huch M
Thu Sep 01 00:00:00 UTC 2016
Xeno-Transplantation of macro-encapsulated islets and Pluripotent Stem Cell-Derived Pancreatic Progenitors without Immunosuppression.
Journal of stem cell and transplantation biology
Bukys MA,Bakos B,Afelik S,Zimmerman B,Barbaro B,Lin DL,Vaca P,Goldman T,Rotem A,Damaser M,Oberholzer J,Barkai U,Jensen J
100-26 was used in Cell Culture to investigate use of a device termed βAIR together with human embryonic stem cells in islet transplantation.
Wed Sep 21 00:00:00 UTC 2016
Long-term culture of genome-stable bipotent stem cells from adult human liver.
Cell
Huch M,Gehart H,van Boxtel R,Hamer K,Blokzijl F,Verstegen MM,Ellis E,van Wenum M,Fuchs SA,de Ligt J,van de Wetering M,Sasaki N,Boers SJ,Kemperman H,de Jonge J,Ijzermans JN,Nieuwenhuis EE,Hoekstra R,Strom S,Vries RR,van der Laan LJ,Cuppen E,Clevers H
Thu Jan 15 00:00:00 UTC 2015
Multiple roles of extracellular fibroblast growth factors in lung cancer cells.
International journal of oncology
Suzuki T,Yasuda H,Funaishi K,Arai D,Ishioka K,Ohgino K,Tani T,Hamamoto J,Ohashi A,Naoki K,Betsuyaku T,Soejima K
Thu Jan 01 00:00:00 UTC 2015
The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids.
Nature communications
Kessler M,Hoffmann K,Brinkmann V,Thieck O,Jackisch S,Toelle B,Berger H,Mollenkopf HJ,Mangler M,Sehouli J,Fotopoulou C,Meyer TF
Tue Dec 08 00:00:00 UTC 2015
A cost-effective system for differentiation of intestinal epithelium from human induced pluripotent stem cells.
Scientific reports
Ogaki S,Morooka M,Otera K,Kume S
Mon Nov 30 00:00:00 UTC 2015
Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids.
Stem cell reports
Nantasanti S,Spee B,Kruitwagen HS,Chen C,Geijsen N,Oosterhoff LA,van Wolferen ME,Pelaez N,Fieten H,Wubbolts RW,Grinwis GC,Chan J,Huch M,Vries RRG,Clevers H,de Bruin A,Rothuizen J,Penning LC,Schotanus BA
Tue Nov 10 00:00:00 UTC 2015
Induced pluripotent stem cells as a model for diabetes investigation.
Scientific reports
Stepniewski J,Kachamakova-Trojanowska N,Ogrocki D,Szopa M,Matlok M,Beilharz M,Dyduch G,Malecki MT,Jozkowicz A,Dulak J
Thu Feb 26 00:00:00 UTC 2015
Identification of multipotent luminal progenitor cells in human prostate organoid cultures.
Cell
Karthaus WR,Iaquinta PJ,Drost J,Gracanin A,van Boxtel R,Wongvipat J,Dowling CM,Gao D,Begthel H,Sachs N,Vries RGJ,Cuppen E,Chen Y,Sawyers CL,Clevers HC
Thu Sep 25 00:00:00 UTC 2014
Organoid cultures derived from patients with advanced prostate cancer.
Cell
Gao D,Vela I,Sboner A,Iaquinta PJ,Karthaus WR,Gopalan A,Dowling C,Wanjala JN,Undvall EA,Arora VK,Wongvipat J,Kossai M,Ramazanoglu S,Barboza LP,Di W,Cao Z,Zhang QF,Sirota I,Ran L,MacDonald TY,Beltran H,Mosquera JM,Touijer KA,Scardino PT,Laudone VP,Curtis KR,Rathkopf DE,Morris MJ,Danila DC,Slovin SF,Solomon SB,Eastham JA,Chi P,Carver B,Rubin MA,Scher HI,Clevers H,Sawyers CL,Chen Y
Thu Sep 25 00:00:00 UTC 2014
Generation of functional insulin-producing cells from mouse embryonic stem cells through 804G cell-derived extracellular matrix and protein transduction of transcription factors.
Stem cells translational medicine
Kaitsuka T,Noguchi H,Shiraki N,Kubo T,Wei FY,Hakim F,Kume S,Tomizawa K
Wed Jan 01 00:00:00 UTC 2014
High oxygen condition facilitates the differentiation of mouse and human pluripotent stem cells into pancreatic progenitors and insulin-producing cells.
The Journal of biological chemistry
Hakim F,Kaitsuka T,Raeed JM,Wei FY,Shiraki N,Akagi T,Yokota T,Kume S,Tomizawa K
Fri Apr 04 00:00:00 UTC 2014
High oxygen condition facilitates the differentiation of mouse and human pluripotent stem cells into pancreatic progenitors and insulin-producing cells.
The Journal of biological chemistry
Hakim F,Kaitsuka T,Raeed JM,Wei FY,Shiraki N,Akagi T,Yokota T,Kume S,Tomizawa K
Fri Apr 04 00:00:00 UTC 2014
Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix.
Proceedings of the National Academy of Sciences of the United States of America
Martino MM,Briquez PS,Ranga A,Lutolf MP,Hubbell JA
Tue Mar 19 00:00:00 UTC 2013
Functional analysis of a breast cancer-associated FGFR2 single nucleotide polymorphism using zinc finger mediated genome editing.
PloS one
Robbez-Masson LJ,Bödör C,Jones JL,Hurst HC,Fitzgibbon J,Hart IR,Grose RP
Fri Jul 25 00:00:00 UTC 2014
FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior.
The Journal of cell biology
Chioni AM,Grose R
Mon Jun 11 00:00:00 UTC 2012
Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation.
PLoS pathogens
Wu X,Robotham JM,Lee E,Dalton S,Kneteman NM,Gilbert DM,Tang H
Mon Aug 20 00:00:00 UTC 2012
Activation of the canonical bone morphogenetic protein (BMP) pathway during lung morphogenesis and adult lung tissue repair.
PloS one
Sountoulidis A,Stavropoulos A,Giaglis S,Apostolou E,Monteiro R,Chuva de Sousa Lopes SM,Chen H,Stripp BR,Mummery C,Andreakos E,Sideras P
Wed May 15 00:00:00 UTC 2013
Fibroblast growth factor 22 is not essential for skin development and repair but plays a role in tumorigenesis.
PloS one
Jarosz M,Robbez-Masson L,Chioni AM,Cross B,Rosewell I,Grose R
Fri Dec 14 00:00:00 UTC 2012
FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium.
Development (Cambridge, England)
Vega-Hernández M,Kovacs A,De Langhe S,Ornitz DM
Mon Aug 01 00:00:00 UTC 2011
HuR controls lung branching morphogenesis and mesenchymal FGF networks.
Developmental biology
Sgantzis N,Yiakouvaki A,Remboutsika E,Kontoyiannis DL
Wed Jun 15 00:00:00 UTC 2011
Polarized endocytosis of the keratinocyte growth factor receptor in migrating cells: role of SRC-signaling and cortactin.
PloS one
Belleudi F,Scrofani C,Torrisi MR,Mancini P
Mon Aug 27 00:00:00 UTC 2012
Conditional gene inactivation reveals roles for Fgf10 and Fgfr2 in establishing a normal pattern of epithelial branching in the mouse lung.
Developmental dynamics : an official publication of the American Association of Anatomists
Abler LL,Mansour SL,Sun X
Sat Aug 01 00:00:00 UTC 2009
Lack of L-iduronic acid in heparan sulfate affects interaction with growth factors and cell signaling.
The Journal of biological chemistry
Jia J,Maccarana M,Zhang X,Bespalov M,Lindahl U,Li JP
Fri Jun 05 00:00:00 UTC 2009
FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod.
Developmental biology
Hung IH,Yu K,Lavine KJ,Ornitz DM
Sun Jul 15 00:00:00 UTC 2007
FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate.
Developmental biology
Liu Z,Lavine KJ,Hung IH,Ornitz DM
Thu Feb 01 00:00:00 UTC 2007
Elf5 is an epithelium-specific, fibroblast growth factor-sensitive transcription factor in the embryonic lung.
Developmental dynamics : an official publication of the American Association of Anatomists
Metzger DE,Xu Y,Shannon JM
Tue May 01 00:00:00 UTC 2007
Elf5 is an epithelium-specific, fibroblast growth factor-sensitive transcription factor in the embryonic lung.
Developmental dynamics : an official publication of the American Association of Anatomists
Metzger DE,Xu Y,Shannon JM
Tue May 01 00:00:00 UTC 2007
Essential role of heparan sulfate 2-O-sulfotransferase in chick limb bud patterning and development.
The Journal of biological chemistry
Kobayashi T,Habuchi H,Tamura K,Ide H,Kimata K
Fri Jul 06 00:00:00 UTC 2007
FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains.
Development (Cambridge, England)
White AC,Xu J,Yin Y,Smith C,Schmid G,Ornitz DM
Sat Apr 01 00:00:00 UTC 2006
Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development.
Development (Cambridge, England)
Zhang X,Stappenbeck TS,White AC,Lavine KJ,Gordon JI,Ornitz DM
Sun Jan 01 00:00:00 UTC 2006
BMP and FGF regulate the differentiation of multipotential pericardial mesoderm into the myocardial or epicardial lineage.
Developmental biology
Kruithof BP,van Wijk B,Somi S,Kruithof-de Julio M,Pérez Pomares JM,Weesie F,Wessels A,Moorman AF,van den Hoff MJ
Sat Jul 15 00:00:00 UTC 2006
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
The Journal of biological chemistry
Zhang X,Ibrahimi OA,Olsen SK,Umemori H,Mohammadi M,Ornitz DM
Fri Jun 09 00:00:00 UTC 2006
ERM is required for transcriptional control of the spermatogonial stem cell niche.
Nature
Chen C,Ouyang W,Grigura V,Zhou Q,Carnes K,Lim H,Zhao GQ,Arber S,Kurpios N,Murphy TL,Cheng AM,Hassell JA,Chandrashekar V,Hofmann MC,Hess RA,Murphy KM
Thu Aug 18 00:00:00 UTC 2005
Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo.
Developmental cell
Lavine KJ,Yu K,White AC,Zhang X,Smith C,Partanen J,Ornitz DM
Sat Jan 01 00:00:00 UTC 2005
Induction of bud formation of embryonic mouse tracheal epithelium by fibroblast growth factor plus transferrin in mesenchyme-free culture.
Developmental dynamics : an official publication of the American Association of Anatomists
Ohtsuka N,Urase K,Momoi T,Nogawa H
Mon Oct 01 00:00:00 UTC 2001
